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Murcko scaffold

Ring system with 2 rings and 18 atoms

56 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
56
With full pages
23
Scaffold SMILES

O=C(COC(=O)c1cccnc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)c1cccnc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 56 chemicals

3-Pyridinecarboxylic acid, 2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl ester chemical structure, C15H13NO5, CAS 19767-91-0
3-Pyridinecarboxylic acid, 2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl ester
CAS 19767-91-0C15H13NO5
2-(4-Bromophenyl)-2-oxoethyl nicotinate chemical structure, C14H10BrNO3, CAS 293326-80-4
2-(4-Bromophenyl)-2-oxoethyl nicotinate
CAS 293326-80-4C14H10BrNO3
[2-(4-Nitrophenyl)-2-oxoethyl] pyridine-3-carboxylate chemical structure, C14H10N2O5, CAS 306764-08-9
[2-(4-Nitrophenyl)-2-oxoethyl] pyridine-3-carboxylate
CAS 306764-08-9C14H10N2O5
Nicotinic acid 2-(3,4-dichloro-phenyl)-2-oxo-ethyl ester chemical structure, C14H9Cl2NO3, CAS 524042-09-9
Nicotinic acid 2-(3,4-dichloro-phenyl)-2-oxo-ethyl ester
CAS 524042-09-9C14H9Cl2NO3
[2-[4-(Difluoromethoxy)phenyl]-2-oxoethyl] 2-chloropyridine-3-carboxylate chemical structure, C15H10ClF2NO4, CAS 473405-32-2
[2-[4-(Difluoromethoxy)phenyl]-2-oxoethyl] 2-chloropyridine-3-carboxylate
CAS 473405-32-2C15H10ClF2NO4
2-Oxo-2-(p-tolyl)ethyl 2-aminonicotinate chemical structure, C15H14N2O3, CAS 652973-85-8
2-Oxo-2-(p-tolyl)ethyl 2-aminonicotinate
CAS 652973-85-8C15H14N2O3
2-Oxo-2-phenylethyl 5,6-dichloropyridine-3-carboxylate chemical structure, C14H9Cl2NO3, CAS 380436-19-1
2-Oxo-2-phenylethyl 5,6-dichloropyridine-3-carboxylate
CAS 380436-19-1C14H9Cl2NO3
Phenacyl 2-ethoxypyridine-3-carboxylate chemical structure, C16H15NO4, CAS 380438-68-6
Phenacyl 2-ethoxypyridine-3-carboxylate
CAS 380438-68-6C16H15NO4
2-(3-Chlorophenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate chemical structure, C14H9Cl2NO3, CAS 380438-74-4
2-(3-Chlorophenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate
CAS 380438-74-4C14H9Cl2NO3
[2-(3,4-Dimethylphenyl)-2-oxoethyl] 2-ethoxypyridine-3-carboxylate chemical structure, C18H19NO4, CAS 485379-45-1
[2-(3,4-Dimethylphenyl)-2-oxoethyl] 2-ethoxypyridine-3-carboxylate
CAS 485379-45-1C18H19NO4
2-(4-Chlorophenyl)-2-oxoethyl 5,6-dichloropyridine-3-carboxylate chemical structure, C14H8Cl3NO3, CAS 391651-99-3
2-(4-Chlorophenyl)-2-oxoethyl 5,6-dichloropyridine-3-carboxylate
CAS 391651-99-3C14H8Cl3NO3
[2-(4-Fluorophenyl)-2-oxoethyl] 5,6-dichloropyridine-3-carboxylate chemical structure, C14H8Cl2FNO3, CAS 380546-18-9
[2-(4-Fluorophenyl)-2-oxoethyl] 5,6-dichloropyridine-3-carboxylate
CAS 380546-18-9C14H8Cl2FNO3
2-(2-Bromophenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate chemical structure, C14H9BrClNO3, CAS 380548-04-9
2-(2-Bromophenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate
CAS 380548-04-9C14H9BrClNO3
2-(2-Bromophenyl)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C15H12BrNO3S, CAS 380548-42-5
2-(2-Bromophenyl)-2-oxoethyl 2-(methylthio)nicotinate
CAS 380548-42-5C15H12BrNO3S
Phenacyl 2-methylsulfanylpyridine-3-carboxylate chemical structure, C15H13NO3S, CAS 482352-28-3
Phenacyl 2-methylsulfanylpyridine-3-carboxylate
CAS 482352-28-3C15H13NO3S
[2-(4-Methoxyphenyl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate chemical structure, C16H15NO4S, CAS 485351-18-6
[2-(4-Methoxyphenyl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate
CAS 485351-18-6C16H15NO4S
2-Chloro-3-pyridinecarboxylic acid [2-(4-fluorophenyl)-2-oxoethyl] ester chemical structure, C14H9ClFNO3, CAS 389620-29-5
2-Chloro-3-pyridinecarboxylic acid [2-(4-fluorophenyl)-2-oxoethyl] ester
CAS 389620-29-5C14H9ClFNO3
2-(2,5-Dimethoxyphenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate chemical structure, C16H14ClNO5, CAS 482297-79-0
2-(2,5-Dimethoxyphenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate
CAS 482297-79-0C16H14ClNO5
2-(4-Ethylphenyl)-2-oxoethyl 5,6-dichloropyridine-3-carboxylate chemical structure, C16H13Cl2NO3, CAS 730982-55-5
2-(4-Ethylphenyl)-2-oxoethyl 5,6-dichloropyridine-3-carboxylate
CAS 730982-55-5C16H13Cl2NO3
[2-(2,4-Dichlorophenyl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate chemical structure, C15H11Cl2NO3S, CAS 473670-28-9
[2-(2,4-Dichlorophenyl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate
CAS 473670-28-9C15H11Cl2NO3S
[2-(2,4-Dichlorophenyl)-2-oxoethyl] 2-chloropyridine-3-carboxylate chemical structure, C14H8Cl3NO3, CAS 389620-25-1
[2-(2,4-Dichlorophenyl)-2-oxoethyl] 2-chloropyridine-3-carboxylate
CAS 389620-25-1C14H8Cl3NO3
[2-Oxo-2-(2,4,6-trimethylphenyl)ethyl] 2-chloropyridine-3-carboxylate chemical structure, C17H16ClNO3, CAS 556008-16-3
[2-Oxo-2-(2,4,6-trimethylphenyl)ethyl] 2-chloropyridine-3-carboxylate
CAS 556008-16-3C17H16ClNO3
2-(2,4-Dimethoxyphenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate chemical structure, C16H14ClNO5, CAS 481670-44-4
2-(2,4-Dimethoxyphenyl)-2-oxoethyl 2-chloropyridine-3-carboxylate
CAS 481670-44-4C16H14ClNO5
2-(3-Bromophenyl)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C15H12BrNO3S, CAS 481638-59-9
2-(3-Bromophenyl)-2-oxoethyl 2-(methylthio)nicotinate
CAS 481638-59-9C15H12BrNO3S