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Murcko scaffold

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-phenylbenzenesulfonamide scaffold

35 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 29
Chemicals: 35
With full pages: 4

Scaffold SMILES

O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-phenylbenzenesulfonamide page

Murcko scaffold O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-ethoxy-N-phenylbenzenesulfonamide chemical structure, C25H26N2O4S, CAS 432000-71-0

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-ethoxy-N-phenylbenzenesulfonamide

CAS 432000-71-0C₂₅H₂₆N₂O₄S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide chemical structure, C26H28N2O4S, CAS 425665-76-5

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide

CAS 425665-76-5C₂₆H₂₈N₂O₄S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methoxy-N-phenylbenzenesulfonamide chemical structure, C24H24N2O4S, CAS 352560-87-3

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methoxy-N-phenylbenzenesulfonamide

CAS 352560-87-3C₂₄H₂₄N₂O₄S

N-(5-Chloro-2-methylphenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C25H25ClN2O3S, CAS 369621-41-0

N-(5-Chloro-2-methylphenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methylbenzenesulfonamide

CAS 369621-41-0C₂₅H₂₅ClN₂O₃S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(3,5-dimethylphenyl)-4-methylbenzenesulfonamide chemical structure, C26H28N2O3S, CAS 425666-25-7

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(3,5-dimethylphenyl)-4-methylbenzenesulfonamide

CAS 425666-25-7C₂₆H₂₈N₂O₃S

4-Chloro-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(4-ethoxyphenyl)benzenesulfonamide chemical structure, C25H25ClN2O4S, CAS 494832-80-3

4-Chloro-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(4-ethoxyphenyl)benzenesulfonamide

CAS 494832-80-3C₂₅H₂₅ClN₂O₄S

N-(3-Chloro-4-methylphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C25H25ClN2O3S, CAS 426228-20-8

N-(3-Chloro-4-methylphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide

CAS 426228-20-8C₂₅H₂₅ClN₂O₃S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide chemical structure, C24H21F3N2O3S, CAS 428472-69-9

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide

CAS 428472-69-9C₂₄H₂₁F₃N₂O₃S

N-(3-Chlorophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C24H23ClN2O3S, CAS 428496-36-0

N-(3-Chlorophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide

CAS 428496-36-0C₂₄H₂₃ClN₂O₃S

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(3,5-dimethylphenyl)-3,4-dimethoxybenzenesulfonamide chemical structure, C27H30N2O5S, CAS 409355-26-6

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(3,5-dimethylphenyl)-3,4-dimethoxybenzenesulfonamide

CAS 409355-26-6C₂₇H₃₀N₂O₅S

N-(4-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C24H23ClN2O3S, CAS 428495-45-8

N-(4-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methylbenzenesulfonamide

CAS 428495-45-8C₂₄H₂₃ClN₂O₃S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(4-propan-2-ylphenyl)benzenesulfonamide chemical structure, C26H28N2O3S, CAS 428469-96-9

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(4-propan-2-ylphenyl)benzenesulfonamide

CAS 428469-96-9C₂₆H₂₈N₂O₃S

N-(3-Bromophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C24H23BrN2O3S, CAS 428495-99-2

N-(3-Bromophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide

CAS 428495-99-2C₂₄H₂₃BrN₂O₃S

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(4-fluorophenyl)-4-methylbenzenesulfonamide chemical structure, C24H23FN2O3S, CAS 428494-05-7

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(4-fluorophenyl)-4-methylbenzenesulfonamide

CAS 428494-05-7C₂₄H₂₃FN₂O₃S

N-(5-Chloro-2-methoxyphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C25H25ClN2O4S, CAS 501914-11-0

N-(5-Chloro-2-methoxyphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide

CAS 501914-11-0C₂₅H₂₅ClN₂O₄S

N-(4-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methoxybenzenesulfonamide chemical structure, C24H23ClN2O4S, CAS 432538-00-6

N-(4-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methoxybenzenesulfonamide

CAS 432538-00-6C₂₄H₂₃ClN₂O₄S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(2-methoxyphenyl)-4-methylbenzenesulfonamide chemical structure, C25H26N2O4S, CAS 432508-46-8

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(2-methoxyphenyl)-4-methylbenzenesulfonamide

CAS 432508-46-8C₂₅H₂₆N₂O₄S

N-(3-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methoxybenzenesulfonamide chemical structure, C24H23ClN2O4S, CAS 640717-61-9

N-(3-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-methoxybenzenesulfonamide

CAS 640717-61-9C₂₄H₂₃ClN₂O₄S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(3-nitrophenyl)benzenesulfonamide chemical structure, C23H21N3O5S, CAS 332033-98-4

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(3-nitrophenyl)benzenesulfonamide

CAS 332033-98-4C₂₃H₂₁N₃O₅S

N-[2-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-4-ethoxy-N-(4-methylphenyl)benzenesulfonamide chemical structure, C26H28N2O4S, CAS 5869-85-2

N-[2-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-4-ethoxy-N-(4-methylphenyl)benzenesulfonamide

CAS 5869-85-2C₂₆H₂₈N₂O₄S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-phenylbenzenesulfonamide chemical structure, C23H22N2O3S, CAS 331727-13-0

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-phenylbenzenesulfonamide

CAS 331727-13-0C₂₃H₂₂N₂O₃S

N-(4-Bromophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C23H21BrN2O3S, CAS 5522-69-0

N-(4-Bromophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]benzenesulfonamide

CAS 5522-69-0C₂₃H₂₁BrN₂O₃S

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(2,5-dimethoxyphenyl)benzenesulfonamide chemical structure, C25H26N2O5S, CAS 5655-37-8

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(2,5-dimethoxyphenyl)benzenesulfonamide

CAS 5655-37-8C₂₅H₂₆N₂O₅S

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(2,5-dimethoxyphenyl)-4-methylbenzenesulfonamide chemical structure, C26H28N2O5S, CAS 420833-31-4

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(2,5-dimethoxyphenyl)-4-methylbenzenesulfonamide

CAS 420833-31-4C₂₆H₂₈N₂O₅S