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Murcko scaffold

Ring system with 4 rings and 26 atoms

66 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 66
With full pages: 6

Scaffold SMILES

O=C1CN(C(=O)c2ccccc2)c2ccccc2N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1CN(C(=O)c2ccccc2)c2ccccc2N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 66 chemicals

4-(4-Fluorobenzoyl)-1-{4-nitrobenzyl}-3,3-dimethyl-3,4-dihydro-2(1H)-quinoxalinone chemical structure, C24H20FN3O4, CAS 312596-45-5

4-(4-Fluorobenzoyl)-1-{4-nitrobenzyl}-3,3-dimethyl-3,4-dihydro-2(1H)-quinoxalinone

CAS 312596-45-5C₂₄H₂₀FN₃O₄

4-(4-Methoxybenzoyl)-3,3-dimethyl-1-(4-nitrobenzyl)-3,4-dihydroquinoxalin-2(1H)-one chemical structure, C25H23N3O5, CAS 381698-23-3

4-(4-Methoxybenzoyl)-3,3-dimethyl-1-(4-nitrobenzyl)-3,4-dihydroquinoxalin-2(1H)-one

CAS 381698-23-3C₂₅H₂₃N₃O₅

4-(4-Chlorobenzoyl)-3,3-dimethyl-1-[(4-nitrophenyl)methyl]quinoxalin-2-one chemical structure, C24H20ClN3O4, CAS 381190-10-9

4-(4-Chlorobenzoyl)-3,3-dimethyl-1-[(4-nitrophenyl)methyl]quinoxalin-2-one

CAS 381190-10-9C₂₄H₂₀ClN₃O₄

1-Benzyl-3,3-dimethyl-4-(3-methylbenzoyl)quinoxalin-2-one chemical structure, C25H24N2O2, CAS 378207-03-5

1-Benzyl-3,3-dimethyl-4-(3-methylbenzoyl)quinoxalin-2-one

CAS 378207-03-5C₂₅H₂₄N₂O₂

1-Benzyl-4-(4-bromobenzoyl)-3,3-dimethylquinoxalin-2-one chemical structure, C24H21BrN2O2, CAS 378216-12-7

1-Benzyl-4-(4-bromobenzoyl)-3,3-dimethylquinoxalin-2-one

CAS 378216-12-7C₂₄H₂₁BrN₂O₂

1-Benzyl-3,3-dimethyl-4-(4-nitrobenzoyl)quinoxalin-2-one chemical structure, C24H21N3O4, CAS 6036-43-7

1-Benzyl-3,3-dimethyl-4-(4-nitrobenzoyl)quinoxalin-2-one

CAS 6036-43-7C₂₄H₂₁N₃O₄

1-[(2,4-Dimethylphenyl)methyl]-3,3-dimethyl-4-(3-nitrobenzoyl)quinoxalin-2-one chemical structure, C26H25N3O4, CAS 380589-64-0

1-[(2,4-Dimethylphenyl)methyl]-3,3-dimethyl-4-(3-nitrobenzoyl)quinoxalin-2-one

CAS 380589-64-0C₂₆H₂₅N₃O₄

1-[(3,4-Dichlorophenyl)methyl]-3,3-dimethyl-4-(4-nitrobenzoyl)-3,4-dihydroquinoxalin-2(1H)-one chemical structure, C24H19Cl2N3O4, CAS 6043-17-0

1-[(3,4-Dichlorophenyl)methyl]-3,3-dimethyl-4-(4-nitrobenzoyl)-3,4-dihydroquinoxalin-2(1H)-one

CAS 6043-17-0C₂₄H₁₉Cl₂N₃O₄

4-(4-Bromobenzoyl)-3,3-dimethyl-1-[(4-nitrophenyl)methyl]quinoxalin-2-one chemical structure, C24H20BrN3O4, CAS 378757-26-7

4-(4-Bromobenzoyl)-3,3-dimethyl-1-[(4-nitrophenyl)methyl]quinoxalin-2-one

CAS 378757-26-7C₂₄H₂₀BrN₃O₄

1-[(3,4-Dichlorophenyl)methyl]-3,3-dimethyl-4-(3-nitrobenzoyl)quinoxalin-2-one chemical structure, C24H19Cl2N3O4, CAS 376602-11-8

1-[(3,4-Dichlorophenyl)methyl]-3,3-dimethyl-4-(3-nitrobenzoyl)quinoxalin-2-one

CAS 376602-11-8C₂₄H₁₉Cl₂N₃O₄

1-[(2,4-Dimethylphenyl)methyl]-3,3-dimethyl-4-(4-nitrobenzoyl)quinoxalin-2-one chemical structure, C26H25N3O4, CAS 378761-40-1

1-[(2,4-Dimethylphenyl)methyl]-3,3-dimethyl-4-(4-nitrobenzoyl)quinoxalin-2-one

CAS 378761-40-1C₂₆H₂₅N₃O₄

1-Benzyl-3,3-dimethyl-4-(4-methylbenzoyl)quinoxalin-2-one chemical structure, C25H24N2O2, CAS 380586-25-4

1-Benzyl-3,3-dimethyl-4-(4-methylbenzoyl)quinoxalin-2-one

CAS 380586-25-4C₂₅H₂₄N₂O₂

1-Benzyl-4-(4-chlorobenzoyl)-3,3-dimethylquinoxalin-2-one chemical structure, C24H21ClN2O2, CAS 314040-26-1

1-Benzyl-4-(4-chlorobenzoyl)-3,3-dimethylquinoxalin-2-one

CAS 314040-26-1C₂₄H₂₁ClN₂O₂

1-Benzyl-3,3-dimethyl-4-(3-nitrobenzoyl)quinoxalin-2-one chemical structure, C24H21N3O4, CAS 376614-71-0

1-Benzyl-3,3-dimethyl-4-(3-nitrobenzoyl)quinoxalin-2-one

CAS 376614-71-0C₂₄H₂₁N₃O₄

1-[(2,4-Dimethylphenyl)methyl]-4-(4-fluorobenzoyl)-3,3-dimethylquinoxalin-2-one chemical structure, C26H25FN2O2, CAS 314040-28-3

1-[(2,4-Dimethylphenyl)methyl]-4-(4-fluorobenzoyl)-3,3-dimethylquinoxalin-2-one

CAS 314040-28-3C₂₆H₂₅FN₂O₂

4-(4-Bromobenzoyl)-1-[(3,4-dichlorophenyl)methyl]-3,3-dimethylquinoxalin-2-one chemical structure, C24H19BrCl2N2O2, CAS 380585-65-9

4-(4-Bromobenzoyl)-1-[(3,4-dichlorophenyl)methyl]-3,3-dimethylquinoxalin-2-one

CAS 380585-65-9C₂₄H₁₉BrCl₂N₂O₂

1-(2,4-Dichlorobenzyl)-4-(4-fluorobenzoyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone chemical structure, C23H17Cl2FN2O2, CAS 317833-35-5

1-(2,4-Dichlorobenzyl)-4-(4-fluorobenzoyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone

CAS 317833-35-5C₂₃H₁₇Cl₂FN₂O₂

1-[4-(tert-Butyl)benzyl]-4-(2,6-difluorobenzoyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone chemical structure, C27H26F2N2O2, CAS 317833-55-9

1-[4-(tert-Butyl)benzyl]-4-(2,6-difluorobenzoyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone

CAS 317833-55-9C₂₇H₂₆F₂N₂O₂

1-[(3-Chlorophenyl)methyl]-3-methyl-4-[3-(trifluoromethyl)benzoyl]-3H-quinoxalin-2-one chemical structure, C24H18ClF3N2O2, CAS 317822-39-2

1-[(3-Chlorophenyl)methyl]-3-methyl-4-[3-(trifluoromethyl)benzoyl]-3H-quinoxalin-2-one

CAS 317822-39-2C₂₄H₁₈ClF₃N₂O₂

4-Benzoyl-1-[4-(tert-butyl)benzyl]-3-methyl-3,4-dihydro-2(1H)-quinoxalinone chemical structure, C27H28N2O2, CAS 317822-25-6

4-Benzoyl-1-[4-(tert-butyl)benzyl]-3-methyl-3,4-dihydro-2(1H)-quinoxalinone

CAS 317822-25-6C₂₇H₂₈N₂O₂

4-(2,6-Difluorobenzoyl)-1-(2-fluorobenzyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone chemical structure, C23H17F3N2O2, CAS 317833-46-8

4-(2,6-Difluorobenzoyl)-1-(2-fluorobenzyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone

CAS 317833-46-8C₂₃H₁₇F₃N₂O₂

4-(4-Chlorobenzoyl)-1-[(2,4-dichlorophenyl)methyl]-3-methyl-3H-quinoxalin-2-one chemical structure, C23H17Cl3N2O2, CAS 317822-45-0

4-(4-Chlorobenzoyl)-1-[(2,4-dichlorophenyl)methyl]-3-methyl-3H-quinoxalin-2-one

CAS 317822-45-0C₂₃H₁₇Cl₃N₂O₂

Methyl 4-[[4-(4-fluorobenzoyl)-3-methyl-2-oxo-3H-quinoxalin-1-yl]methyl]benzoate chemical structure, C25H21FN2O4, CAS 317833-42-4

Methyl 4-[[4-(4-fluorobenzoyl)-3-methyl-2-oxo-3H-quinoxalin-1-yl]methyl]benzoate

CAS 317833-42-4C₂₅H₂₁FN₂O₄

4-(4-Fluorobenzoyl)-1-(2-fluorobenzyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone chemical structure, C23H18F2N2O2, CAS 317833-43-5

4-(4-Fluorobenzoyl)-1-(2-fluorobenzyl)-3-methyl-3,4-dihydro-2(1H)-quinoxalinone

CAS 317833-43-5C₂₃H₁₈F₂N₂O₂