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Murcko scaffold

1-(4-Pyridyl)piperazine scaffold

263 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
263
With full pages
27
Scaffold SMILES

c1cc(N2CCNCC2)ccn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(4-Pyridyl)piperazine page
Murcko scaffold c1cc(N2CCNCC2)ccn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 263 chemicals

1-(4-Pyridyl)piperazine chemical structure, C9H13N3, CAS 1008-91-9
1-(4-Pyridyl)piperazine
CAS 1008-91-9C9H13N3
Piperazine, 1-(3-amino-4-pyridyl)-4-methyl- chemical structure, C10H16N4, CAS 14549-59-8
Piperazine, 1-(3-amino-4-pyridyl)-4-methyl-
CAS 14549-59-8C10H16N4
N-Methyl-4-(4-propan-2-ylpiperazin-1-yl)pyridine-3-sulfonamide chemical structure, C13H22N4O2S, CAS 57725-23-2
N-Methyl-4-(4-propan-2-ylpiperazin-1-yl)pyridine-3-sulfonamide
CAS 57725-23-2C13H22N4O2S
1-(3,5-Dichloropyridin-4-yl)piperazine chemical structure, C9H11Cl2N3, CAS 175277-80-2
1-(3,5-Dichloropyridin-4-yl)piperazine
CAS 175277-80-2C9H11Cl2N3
Piperazine, 1-(3-amino-4-pyridyl)- chemical structure, C9H14N4, CAS 78069-95-1
Piperazine, 1-(3-amino-4-pyridyl)-
CAS 78069-95-1C9H14N4
1-Piperazineethanol, 4-(3-amino-4-pyridyl)- chemical structure, C11H18N4O, CAS 78091-28-8
1-Piperazineethanol, 4-(3-amino-4-pyridyl)-
CAS 78091-28-8C11H18N4O
1-[4-(Pyridin-4-yl)piperazin-1-yl]ethan-1-one chemical structure, C11H15N3O, CAS 300394-67-6
1-[4-(Pyridin-4-yl)piperazin-1-yl]ethan-1-one
CAS 300394-67-6C11H15N3O
4-(4-Methylpiperazino)pyridine chemical structure, C10H15N3, CAS 86673-46-3
4-(4-Methylpiperazino)pyridine
CAS 86673-46-3C10H15N3
1-(3-Methyl-4-pyridinyl)piperazine chemical structure, C10H15N3, CAS 112940-51-9
1-(3-Methyl-4-pyridinyl)piperazine
CAS 112940-51-9C10H15N3
4-(3-Trifluoromethylpyridin-4-yl)piperazine-1-carboxylic acid tert-butyl ester chemical structure, C15H20F3N3O2, CAS 683240-89-3
4-(3-Trifluoromethylpyridin-4-yl)piperazine-1-carboxylic acid tert-butyl ester
CAS 683240-89-3C15H20F3N3O2
tert-Butyl 4-(3-chloropyridin-4-yl)piperazine-1-carboxylate chemical structure, C14H20ClN3O2, CAS 683240-48-4
tert-Butyl 4-(3-chloropyridin-4-yl)piperazine-1-carboxylate
CAS 683240-48-4C14H20ClN3O2
4-Pyridin-4-ylpiperazine-1-sulfonamide chemical structure, C9H14N4O2S, CAS 869938-76-1
4-Pyridin-4-ylpiperazine-1-sulfonamide
CAS 869938-76-1C9H14N4O2S
(S)-tert-Butyl (5-amino-6-oxo-6-(4-(pyridin-4-yl)piperazin-1-yl)hexyl)carbamate chemical structure, C20H33N5O3, CAS 204692-66-0
(S)-tert-Butyl (5-amino-6-oxo-6-(4-(pyridin-4-yl)piperazin-1-yl)hexyl)carbamate
CAS 204692-66-0C20H33N5O3
1-(3-(Trifluoromethyl)pyridin-4-yl)piperazine chemical structure, C10H12F3N3, CAS 788156-95-6
1-(3-(Trifluoromethyl)pyridin-4-yl)piperazine
CAS 788156-95-6C10H12F3N3
1-(3-Chloropyridin-4-yl)piperazine chemical structure, C9H12ClN3, CAS 87394-66-9
1-(3-Chloropyridin-4-yl)piperazine
CAS 87394-66-9C9H12ClN3
1-(1-Oxo-1lambda~5~-pyridin-4-yl)piperazine chemical structure, C9H13N3O, CAS 337956-37-3
1-(1-Oxo-1lambda~5~-pyridin-4-yl)piperazine
CAS 337956-37-3C9H13N3O
1-(3-Methoxypyridin-4-yl)piperazine chemical structure, C10H15N3O, CAS 151140-92-0
1-(3-Methoxypyridin-4-yl)piperazine
CAS 151140-92-0C10H15N3O
3-[4-(Pyridin-4-yl)piperazin-1-yl]propanoic acid chemical structure, C12H17N3O2, CAS 179688-92-7
3-[4-(Pyridin-4-yl)piperazin-1-yl]propanoic acid
CAS 179688-92-7C12H17N3O2
1-(2-Methylpyridin-4-yl)piperazine chemical structure, C10H15N3, CAS 98010-38-9
1-(2-Methylpyridin-4-yl)piperazine
CAS 98010-38-9C10H15N3
N-Methyl-4-piperazin-1-ylpyridine-2-carboxamide chemical structure, C11H16N4O, CAS 926244-85-1
N-Methyl-4-piperazin-1-ylpyridine-2-carboxamide
CAS 926244-85-1C11H16N4O
1-(2-Methylpyridin-4-yl)piperazine dihydrochloride chemical structure, C10H17Cl2N3, CAS 166954-05-8
1-(2-Methylpyridin-4-yl)piperazine dihydrochloride
CAS 166954-05-8C10H17Cl2N3
tert-Butyl 4-(2-methylpyridin-4-yl)piperazine-1-carboxylate chemical structure, C15H23N3O2, CAS 392332-15-9
tert-Butyl 4-(2-methylpyridin-4-yl)piperazine-1-carboxylate
CAS 392332-15-9C15H23N3O2
4-(4-Pyridinyl)-1-piperazinecarboxylic acid chemical structure, C10H13N3O2, CAS 664367-53-7
4-(4-Pyridinyl)-1-piperazinecarboxylic acid
CAS 664367-53-7C10H13N3O2
1-(2-Chloro-6-methylpyridin-4-yl)piperazine chemical structure, C10H14ClN3, CAS 179334-19-1
1-(2-Chloro-6-methylpyridin-4-yl)piperazine
CAS 179334-19-1C10H14ClN3