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Murcko scaffold

1,4-Diphenyl-1,4-butanedione scaffold

50 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
50
With full pages
4
Scaffold SMILES

O=C(CCC(=O)c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Diphenyl-1,4-butanedione page
Murcko scaffold O=C(CCC(=O)c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

1,4-Diphenyl-1,4-butanedione chemical structure, C16H14O2, CAS 495-71-6
1,4-Diphenyl-1,4-butanedione
CAS 495-71-6C16H14O2
1,4-Bis(4-bromophenyl)-1,4-butanedione chemical structure, C16H12Br2O2, CAS 2461-83-8
1,4-Bis(4-bromophenyl)-1,4-butanedione
CAS 2461-83-8C16H12Br2O2
2-(Dimethylamino)-1,4-diphenylbutane-1,4-dione chemical structure, C18H19NO2, CAS 5428-58-0
2-(Dimethylamino)-1,4-diphenylbutane-1,4-dione
CAS 5428-58-0C18H19NO2
2,3-Dibromo-1,4-bis(4-hydroxyphenyl)butane-1,4-dione chemical structure, C16H12Br2O4, CAS 6338-17-6
2,3-Dibromo-1,4-bis(4-hydroxyphenyl)butane-1,4-dione
CAS 6338-17-6C16H12Br2O4
2,3-Dibromo-1-phenyl-4-(4-propan-2-ylphenyl)butane-1,4-dione chemical structure, C19H18Br2O2, CAS 6313-06-0
2,3-Dibromo-1-phenyl-4-(4-propan-2-ylphenyl)butane-1,4-dione
CAS 6313-06-0C19H18Br2O2
1,4-Bis(4-chlorophenyl)butane-1,4-dione chemical structure, C16H12Cl2O2, CAS 24314-35-0
1,4-Bis(4-chlorophenyl)butane-1,4-dione
CAS 24314-35-0C16H12Cl2O2
2,3-Dichloro-1,4-diphenylbutane-1,4-dione chemical structure, C16H12Cl2O2, CAS 5038-48-2
2,3-Dichloro-1,4-diphenylbutane-1,4-dione
CAS 5038-48-2C16H12Cl2O2
1,2-Dibenzoyl-1,2-dibromoethane chemical structure, C16H12Br2O2, CAS 22867-05-6
1,2-Dibenzoyl-1,2-dibromoethane
CAS 22867-05-6C16H12Br2O2
3,4-Dibenzoylhexane-2,5-dione chemical structure, C20H18O4, CAS 51439-47-5
3,4-Dibenzoylhexane-2,5-dione
CAS 51439-47-5C20H18O4
2-Bromo-1,4-diphenyl-1,4-butanedione chemical structure, C16H13BrO2, CAS 63104-99-4
2-Bromo-1,4-diphenyl-1,4-butanedione
CAS 63104-99-4C16H13BrO2
Diethyl 2,3-dibenzoylsuccinate chemical structure, C22H22O6, CAS 4687-38-1
Diethyl 2,3-dibenzoylsuccinate
CAS 4687-38-1C22H22O6
1,4-Butanedione, 1-(4-bromophenyl)-4-phenyl- chemical structure, C16H13BrO2, CAS 51908-41-9
1,4-Butanedione, 1-(4-bromophenyl)-4-phenyl-
CAS 51908-41-9C16H13BrO2
1,4-Di-p-tolylbutane-1,4-dione chemical structure, C18H18O2, CAS 13145-56-7
1,4-Di-p-tolylbutane-1,4-dione
CAS 13145-56-7C18H18O2
1,4-Bis(4-methoxyphenyl)-1,4-butanedione chemical structure, C18H18O4, CAS 15982-64-6
1,4-Bis(4-methoxyphenyl)-1,4-butanedione
CAS 15982-64-6C18H18O4
1,4-Bis(4-fluorophenyl)butane-1,4-dione chemical structure, C16H12F2O2, CAS 108791-65-7
1,4-Bis(4-fluorophenyl)butane-1,4-dione
CAS 108791-65-7C16H12F2O2
1-(4-Methoxy-phenyl)-4-phenyl-butane-1,4-dione chemical structure, C17H16O3, CAS 60755-22-8
1-(4-Methoxy-phenyl)-4-phenyl-butane-1,4-dione
CAS 60755-22-8C17H16O3
Ethyl 2-benzoyl-4-(4-bromophenyl)-4-oxobutanoate chemical structure, C19H17BrO4, CAS 29113-49-3
Ethyl 2-benzoyl-4-(4-bromophenyl)-4-oxobutanoate
CAS 29113-49-3C19H17BrO4
1,4-Bis(2-hydroxy-5-methylphenyl)butane-1,4-dione chemical structure, C18H18O4, CAS 13282-23-0
1,4-Bis(2-hydroxy-5-methylphenyl)butane-1,4-dione
CAS 13282-23-0C18H18O4
1,4-Bis(pentafluorophenyl)-1,4-butanedione chemical structure, C16H4F10O2, CAS 7797-96-8
1,4-Bis(pentafluorophenyl)-1,4-butanedione
CAS 7797-96-8C16H4F10O2
1,2-Dibenzoyl-1-chloroethane chemical structure, C16H13ClO2, CAS 68665-40-7
1,2-Dibenzoyl-1-chloroethane
CAS 68665-40-7C16H13ClO2
1,4-Butanedione, 2-methyl-1,4-diphenyl- chemical structure, C17H16O2, CAS 15982-59-9
1,4-Butanedione, 2-methyl-1,4-diphenyl-
CAS 15982-59-9C17H16O2
1,4-Hexanedione, 3-benzoyl-1-phenyl- chemical structure, C19H18O3, CAS 583029-18-9
1,4-Hexanedione, 3-benzoyl-1-phenyl-
CAS 583029-18-9C19H18O3
Benzoic acid, 4,4'-(1,4-dioxo-1,4-butanediyl)bis-, dimethyl ester chemical structure, C20H18O6, CAS 194298-13-0
Benzoic acid, 4,4'-(1,4-dioxo-1,4-butanediyl)bis-, dimethyl ester
CAS 194298-13-0C20H18O6
3-Benzoyl-1-(4-bromophenyl)pentane-1,4-dione chemical structure, C18H15BrO3, CAS 61668-31-3
3-Benzoyl-1-(4-bromophenyl)pentane-1,4-dione
CAS 61668-31-3C18H15BrO3