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Murcko scaffold

6-(Thiophen-2-yl)pyridin-2(1H)-one scaffold

18 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
18
With full pages
4
Scaffold SMILES

O=c1cccc(-c2cccs2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-(Thiophen-2-yl)pyridin-2(1H)-one page
Murcko scaffold O=c1cccc(-c2cccs2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-Oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile chemical structure, C11H5F3N2OS, CAS 22123-11-1
2-Oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
CAS 22123-11-1C11H5F3N2OS
3-Cyano-2-hydroxy-6-(2-thienyl)-pyridine chemical structure, C10H6N2OS, CAS 56304-76-8
3-Cyano-2-hydroxy-6-(2-thienyl)-pyridine
CAS 56304-76-8C10H6N2OS
1,2-Dihydro-2-oxo-6-(2-thienyl)-3-pyridinecarboxylic acid chemical structure, C10H7NO3S, CAS 56304-45-1
1,2-Dihydro-2-oxo-6-(2-thienyl)-3-pyridinecarboxylic acid
CAS 56304-45-1C10H7NO3S
2-Hydroxy-6-(thiophen-2-yl)pyridine-4-carboxylic acid chemical structure, C10H7NO3S, CAS 925004-40-6
2-Hydroxy-6-(thiophen-2-yl)pyridine-4-carboxylic acid
CAS 925004-40-6C10H7NO3S
6-(5-Bromo-2-thienyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C10H5BrN2OS, CAS 1144460-95-6
6-(5-Bromo-2-thienyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 1144460-95-6C10H5BrN2OS
6-(5-Bromo-2-thienyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid chemical structure, C10H6BrNO3S, CAS 1204296-56-9
6-(5-Bromo-2-thienyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
CAS 1204296-56-9C10H6BrNO3S
6-(Thiophen-2-yl)pyridin-2(1H)-one chemical structure, C9H7NOS, CAS 1111114-71-6
6-(Thiophen-2-yl)pyridin-2(1H)-one
CAS 1111114-71-6C9H7NOS
6-(5-Formylthiophen-2-yl)-2-hydroxypyridine chemical structure, C10H7NO2S, CAS 1261941-36-9
6-(5-Formylthiophen-2-yl)-2-hydroxypyridine
CAS 1261941-36-9C10H7NO2S
6-(5-Chlorothiophen-2-yl)-2-hydroxypyridine-3-carbonitrile chemical structure, C10H5ClN2OS, CAS 1247521-01-2
6-(5-Chlorothiophen-2-yl)-2-hydroxypyridine-3-carbonitrile
CAS 1247521-01-2C10H5ClN2OS
1,2-Dihydro-6-(5-methyl-2-thienyl)-2-oxo-3-pyridinecarboxylic acid chemical structure, C11H9NO3S, CAS 1247224-45-8
1,2-Dihydro-6-(5-methyl-2-thienyl)-2-oxo-3-pyridinecarboxylic acid
CAS 1247224-45-8C11H9NO3S
6-(5-Chloro-2-thienyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid chemical structure, C10H6ClNO3S, CAS 1248631-39-1
6-(5-Chloro-2-thienyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
CAS 1248631-39-1C10H6ClNO3S
1-Methyl-2-oxo-6-(thiophen-2-yl)-1,2-dihydropyridine-4-carboxylic acid chemical structure, C11H9NO3S, CAS 1368545-19-0
1-Methyl-2-oxo-6-(thiophen-2-yl)-1,2-dihydropyridine-4-carboxylic acid
CAS 1368545-19-0C11H9NO3S
Methyl 2-hydroxy-6-(thiophen-2-yl)pyrimidin-4-carboxylate chemical structure, C11H9NO3S, CAS 925004-73-5
Methyl 2-hydroxy-6-(thiophen-2-yl)pyrimidin-4-carboxylate
CAS 925004-73-5C11H9NO3S
Methyl 3-cyano-2-hydroxy-6-(thiophen-2-yl)pyridine-4-carboxylate chemical structure, C12H8N2O3S, CAS 925004-13-3
Methyl 3-cyano-2-hydroxy-6-(thiophen-2-yl)pyridine-4-carboxylate
CAS 925004-13-3C12H8N2O3S
6-(5-Chloro-2-thienyl)-2(1H)-pyridinone chemical structure, C9H6ClNOS, CAS 1111112-96-9
6-(5-Chloro-2-thienyl)-2(1H)-pyridinone
CAS 1111112-96-9C9H6ClNOS
6-(5-Chloro-2-thienyl)-4-(trifluoromethyl)-2(1H)-pyridinone chemical structure, C10H5ClF3NOS, CAS 22123-12-2
6-(5-Chloro-2-thienyl)-4-(trifluoromethyl)-2(1H)-pyridinone
CAS 22123-12-2C10H5ClF3NOS
3-Cyano-2-oxo-6-(thiophen-2-yl)-1,2-dihydropyridine-4-carboxylic acid chemical structure, C11H6N2O3S, CAS 204910-40-7
3-Cyano-2-oxo-6-(thiophen-2-yl)-1,2-dihydropyridine-4-carboxylic acid
CAS 204910-40-7C11H6N2O3S
6-(5-Acetyl-2-thienyl)-2(1H)-pyridinone chemical structure, C11H9NO2S, CAS 1111111-28-4
6-(5-Acetyl-2-thienyl)-2(1H)-pyridinone
CAS 1111111-28-4C11H9NO2S