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Murcko scaffold

Ring system with 4 rings and 30 atoms

59 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
30
Chemicals
59
With full pages
20
Scaffold SMILES

O=C(CSc1nnc(CNc2ccccc2)n1-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(CNc2ccccc2)n1-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

N-(2,3-Dimethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H27N5OS, CAS 332907-06-9
N-(2,3-Dimethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332907-06-9C26H27N5OS
N-(2,5-Dimethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H27N5OS, CAS 332907-11-6
N-(2,5-Dimethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332907-11-6C26H27N5OS
N-(2-Ethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H27N5OS, CAS 493032-82-9
N-(2-Ethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 493032-82-9C26H27N5OS
N-(2,5-Dimethoxyphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H27N5O3S, CAS 332907-12-7
N-(2,5-Dimethoxyphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332907-12-7C26H27N5O3S
N-(2,5-Dimethylphenyl)-2-((5-(((2,6-dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C27H29N5OS, CAS 332911-62-3
N-(2,5-Dimethylphenyl)-2-((5-(((2,6-dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332911-62-3C27H29N5OS
N-(4-Acetylphenyl)-2-((4-phenyl-5-((m-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H25N5O2S, CAS 332930-03-7
N-(4-Acetylphenyl)-2-((4-phenyl-5-((m-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332930-03-7C26H25N5O2S
N-(2,3-Dimethylphenyl)-2-((4-phenyl-5-((m-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H27N5OS, CAS 332930-07-1
N-(2,3-Dimethylphenyl)-2-((4-phenyl-5-((m-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332930-07-1C26H27N5OS
N-(4-Acetylphenyl)-2-({5-[(4-ethoxyanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C27H27N5O3S, CAS 482638-15-3
N-(4-Acetylphenyl)-2-({5-[(4-ethoxyanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 482638-15-3C27H27N5O3S
N-(4-Acetylphenyl)-2-((4-(4-chlorophenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H24ClN5O2S, CAS 482638-19-7
N-(4-Acetylphenyl)-2-((4-(4-chlorophenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 482638-19-7C26H24ClN5O2S
2-[[5-[(2-Methoxyanilino)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylphenyl)acetamide chemical structure, C25H25N5O2S, CAS 354551-65-8
2-[[5-[(2-Methoxyanilino)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylphenyl)acetamide
CAS 354551-65-8C25H25N5O2S
Methyl 4-(2-((5-(((4-chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamido)benzoate chemical structure, C25H22ClN5O3S, CAS 442669-27-4
Methyl 4-(2-((5-(((4-chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamido)benzoate
CAS 442669-27-4C25H22ClN5O3S
Methyl 2-[2-({5-[(3-chloroanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamido]benzoate chemical structure, C25H22ClN5O3S, CAS 5131-29-3
Methyl 2-[2-({5-[(3-chloroanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamido]benzoate
CAS 5131-29-3C25H22ClN5O3S
2-((5-(((2,5-Dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C26H27N5OS, CAS 332376-35-9
2-((5-(((2,5-Dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide
CAS 332376-35-9C26H27N5OS
N-(4-Methyl-3-nitrophenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C25H24N6O3S, CAS 332907-08-1
N-(4-Methyl-3-nitrophenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332907-08-1C25H24N6O3S
N-(4-Ethoxyphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C26H27N5O2S, CAS 445249-56-9
N-(4-Ethoxyphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 445249-56-9C26H27N5O2S
2-((4-Phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide chemical structure, C25H22F3N5OS, CAS 332907-19-4
2-((4-Phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS 332907-19-4C25H22F3N5OS
N-(3,4-Dimethylphenyl)-2-({5-[(4-methoxyanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C26H27N5O2S, CAS 482617-27-6
N-(3,4-Dimethylphenyl)-2-({5-[(4-methoxyanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 482617-27-6C26H27N5O2S
2-((5-((3-Chloroanilino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(4-methylphenyl)acetamide chemical structure, C24H22ClN5OS, CAS 335217-77-1
2-((5-((3-Chloroanilino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(4-methylphenyl)acetamide
CAS 335217-77-1C24H22ClN5OS
N-(2-Bromophenyl)-2-((5-(((4-ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C25H24BrN5O2S, CAS 445229-36-7
N-(2-Bromophenyl)-2-((5-(((4-ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 445229-36-7C25H24BrN5O2S
2-((5-(((4-Ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C26H27N5O2S, CAS 438615-54-4
2-((5-(((4-Ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide
CAS 438615-54-4C26H27N5O2S
2-((4-(4-Chlorophenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide chemical structure, C25H24ClN5OS, CAS 335217-95-3
2-((4-(4-Chlorophenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide
CAS 335217-95-3C25H24ClN5OS
N-(3,5-Dimethylphenyl)-2-((5-(((2,6-dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C27H29N5OS, CAS 332909-20-3
N-(3,5-Dimethylphenyl)-2-((5-(((2,6-dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332909-20-3C27H29N5OS
2-((5-(((4-Chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dimethylphenyl)acetamide chemical structure, C25H24ClN5OS, CAS 352684-82-3
2-((5-(((4-Chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dimethylphenyl)acetamide
CAS 352684-82-3C25H24ClN5OS
N-(2-Chlorophenyl)-2-((5-(((4-chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C23H19Cl2N5OS, CAS 332930-62-8
N-(2-Chlorophenyl)-2-((5-(((4-chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332930-62-8C23H19Cl2N5OS