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Murcko scaffold

Ring system with 2 rings and 18 atoms

12 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
12
With full pages
4
Scaffold SMILES

O=C(CSc1ncccn1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ncccn1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N-Benzyl-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C15H17N3OS, CAS 321974-71-4
N-Benzyl-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
CAS 321974-71-4C15H17N3OS
N-(4-Methylbenzyl)-2-(pyrimidin-2-ylsulfanyl)acetamide chemical structure, C14H15N3OS, CAS 694515-48-5
N-(4-Methylbenzyl)-2-(pyrimidin-2-ylsulfanyl)acetamide
CAS 694515-48-5C14H15N3OS
N-(4-Methylbenzyl)-2-[(4-methylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C15H17N3OS, CAS 702650-89-3
N-(4-Methylbenzyl)-2-[(4-methylpyrimidin-2-yl)sulfanyl]acetamide
CAS 702650-89-3C15H17N3OS
2-[4-Methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-N-[[3-(trifluoromethyl)phenyl]methyl]acetamide chemical structure, C16H13F6N3OS, CAS 330829-29-3
2-[4-Methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-N-[[3-(trifluoromethyl)phenyl]methyl]acetamide
CAS 330829-29-3C16H13F6N3OS
N-[(4-Chlorophenyl)methyl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C13H12ClN3OS, CAS 503142-25-4
N-[(4-Chlorophenyl)methyl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 503142-25-4C13H12ClN3OS
N-Benzyl-2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(propan-2-yl)acetamide chemical structure, C16H21N5OS, CAS 923693-84-9
N-Benzyl-2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(propan-2-yl)acetamide
CAS 923693-84-9C16H21N5OS
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-(1-phenylethyl)butanamide chemical structure, C18H23N3OS, CAS 627057-67-4
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-(1-phenylethyl)butanamide
CAS 627057-67-4C18H23N3OS
2-[(4,6-Diaminopyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)acetamide chemical structure, C14H17N5OS, CAS 328285-52-5
2-[(4,6-Diaminopyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)acetamide
CAS 328285-52-5C14H17N5OS
2-((4,6-Diaminopyrimidin-2-yl)thio)-N-(4-ethoxybenzyl)-N-methylacetamide chemical structure, C16H21N5O2S, CAS 852830-03-6
2-((4,6-Diaminopyrimidin-2-yl)thio)-N-(4-ethoxybenzyl)-N-methylacetamide
CAS 852830-03-6C16H21N5O2S
N-[1-(2,5-Dimethoxyphenyl)ethyl]-2-{[4-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}acetamide chemical structure, C17H18F3N3O3S, CAS 832736-68-2
N-[1-(2,5-Dimethoxyphenyl)ethyl]-2-{[4-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}acetamide
CAS 832736-68-2C17H18F3N3O3S
N-(4-Fluorobenzyl)-2-[(4-methylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C14H14FN3OS, CAS 959243-93-7
N-(4-Fluorobenzyl)-2-[(4-methylpyrimidin-2-yl)sulfanyl]acetamide
CAS 959243-93-7C14H14FN3OS
N-[Cyano(2,4-difluorophenyl)methyl]-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C16H14F2N4OS, CAS 1280922-25-9
N-[Cyano(2,4-difluorophenyl)methyl]-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
CAS 1280922-25-9C16H14F2N4OS