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Murcko scaffold

Ring system with 2 rings and 20 atoms

59 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
20
Chemicals
59
With full pages
15
Scaffold SMILES

O=C(COC(=O)c1cccnc1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)c1cccnc1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

(Benzylcarbamoyl)methyl 2-chloropyridine-3-carboxylate chemical structure, C15H13ClN2O3, CAS 479241-02-6
(Benzylcarbamoyl)methyl 2-chloropyridine-3-carboxylate
CAS 479241-02-6C15H13ClN2O3
{[(4-Methoxyphenyl)methyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate chemical structure, C16H15ClN2O4, CAS 478863-97-7
{[(4-Methoxyphenyl)methyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate
CAS 478863-97-7C16H15ClN2O4
{[(4-Fluorophenyl)methyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate chemical structure, C15H12ClFN2O3, CAS 744268-29-9
{[(4-Fluorophenyl)methyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate
CAS 744268-29-9C15H12ClFN2O3
{[(4-Fluorophenyl)methyl]carbamoyl}methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C15H11Cl2FN2O3, CAS 473819-25-9
{[(4-Fluorophenyl)methyl]carbamoyl}methyl 5,6-dichloropyridine-3-carboxylate
CAS 473819-25-9C15H11Cl2FN2O3
[2-[(4-Chlorophenyl)methylamino]-2-oxoethyl] 5,6-dichloropyridine-3-carboxylate chemical structure, C15H11Cl3N2O3, CAS 391652-09-8
[2-[(4-Chlorophenyl)methylamino]-2-oxoethyl] 5,6-dichloropyridine-3-carboxylate
CAS 391652-09-8C15H11Cl3N2O3
2-((4-Methoxybenzyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C17H18N2O4S, CAS 572879-06-2
2-((4-Methoxybenzyl)amino)-2-oxoethyl 2-(methylthio)nicotinate
CAS 572879-06-2C17H18N2O4S
[2-[(4-Fluorophenyl)methylamino]-2-oxoethyl] 6-chloropyridine-3-carboxylate chemical structure, C15H12ClFN2O3, CAS 437625-15-5
[2-[(4-Fluorophenyl)methylamino]-2-oxoethyl] 6-chloropyridine-3-carboxylate
CAS 437625-15-5C15H12ClFN2O3
2-(Benzylamino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C16H16N2O3S, CAS 380190-80-7
2-(Benzylamino)-2-oxoethyl 2-(methylthio)nicotinate
CAS 380190-80-7C16H16N2O3S
(Benzylcarbamoyl)methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C15H12Cl2N2O3, CAS 380437-67-2
(Benzylcarbamoyl)methyl 5,6-dichloropyridine-3-carboxylate
CAS 380437-67-2C15H12Cl2N2O3
[2-(Benzylamino)-2-oxoethyl] 2-ethoxypyridine-3-carboxylate chemical structure, C17H18N2O4, CAS 380438-12-0
[2-(Benzylamino)-2-oxoethyl] 2-ethoxypyridine-3-carboxylate
CAS 380438-12-0C17H18N2O4
2-(Benzylamino)-2-oxoethyl 5-bromonicotinate chemical structure, C15H13BrN2O3, CAS 380555-94-2
2-(Benzylamino)-2-oxoethyl 5-bromonicotinate
CAS 380555-94-2C15H13BrN2O3
6-Chloro-nicotinic acid benzylcarbamoyl-methyl ester chemical structure, C15H13ClN2O3, CAS 380573-85-3
6-Chloro-nicotinic acid benzylcarbamoyl-methyl ester
CAS 380573-85-3C15H13ClN2O3
{[(4-Methoxyphenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate chemical structure, C16H15ClN2O4, CAS 380556-14-9
{[(4-Methoxyphenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate
CAS 380556-14-9C16H15ClN2O4
[Benzyl(methyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C16H14Cl2N2O3, CAS 380211-98-3
[Benzyl(methyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate
CAS 380211-98-3C16H14Cl2N2O3
2-((4-Chlorobenzyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C16H15ClN2O3S, CAS 475054-89-8
2-((4-Chlorobenzyl)amino)-2-oxoethyl 2-(methylthio)nicotinate
CAS 475054-89-8C16H15ClN2O3S
{[(2-Methoxyphenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate chemical structure, C16H15ClN2O4, CAS 386278-31-5
{[(2-Methoxyphenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate
CAS 386278-31-5C16H15ClN2O4
[2-[Benzyl(propan-2-yl)amino]-2-oxoethyl] 5,6-dichloropyridine-3-carboxylate chemical structure, C18H18Cl2N2O3, CAS 736954-07-7
[2-[Benzyl(propan-2-yl)amino]-2-oxoethyl] 5,6-dichloropyridine-3-carboxylate
CAS 736954-07-7C18H18Cl2N2O3
[Benzyl(tert-butyl)carbamoyl]methyl 6-chloropyridine-3-carboxylate chemical structure, C19H21ClN2O3, CAS 736957-40-7
[Benzyl(tert-butyl)carbamoyl]methyl 6-chloropyridine-3-carboxylate
CAS 736957-40-7C19H21ClN2O3
2-(Benzyl(methyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C17H18N2O3S, CAS 722489-30-7
2-(Benzyl(methyl)amino)-2-oxoethyl 2-(methylthio)nicotinate
CAS 722489-30-7C17H18N2O3S
{[(2-Methoxyphenyl)methyl]carbamoyl}methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C16H14Cl2N2O4, CAS 391652-10-1
{[(2-Methoxyphenyl)methyl]carbamoyl}methyl 5,6-dichloropyridine-3-carboxylate
CAS 391652-10-1C16H14Cl2N2O4
[2-[(4-Methylphenyl)methylamino]-2-oxoethyl] 2-chloropyridine-3-carboxylate chemical structure, C16H15ClN2O3, CAS 554425-23-9
[2-[(4-Methylphenyl)methylamino]-2-oxoethyl] 2-chloropyridine-3-carboxylate
CAS 554425-23-9C16H15ClN2O3
{[(2-Chlorophenyl)methyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate chemical structure, C15H12Cl2N2O3, CAS 389811-03-4
{[(2-Chlorophenyl)methyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate
CAS 389811-03-4C15H12Cl2N2O3
{[(4-Chlorophenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate chemical structure, C15H12Cl2N2O3, CAS 386278-30-4
{[(4-Chlorophenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate
CAS 386278-30-4C15H12Cl2N2O3
{[(2-Chlorophenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate chemical structure, C15H12Cl2N2O3, CAS 386279-13-6
{[(2-Chlorophenyl)methyl]carbamoyl}methyl 6-chloropyridine-3-carboxylate
CAS 386279-13-6C15H12Cl2N2O3