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Murcko scaffold

Ring system with 3 rings and 31 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
31
Chemicals
12
With full pages
11
Scaffold SMILES

O=C(C=Cc1ccccc1)Oc1ccc(C=NNC(=O)C(=O)Nc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)Oc1ccc(C=NNC(=O)C(=O)Nc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

4-((2-(2-((4-Fluorophenyl)amino)-2-oxoacetyl)hydrazono)methyl)-2-methoxyphenyl cinnamate chemical structure, C25H20FN3O5, CAS 477729-04-7
4-((2-(2-((4-Fluorophenyl)amino)-2-oxoacetyl)hydrazono)methyl)-2-methoxyphenyl cinnamate
CAS 477729-04-7C25H20FN3O5
4-((E)-(((3-Chloro-2-methylanilino)(oxo)acetyl)hydrazono)methyl)-2-methoxyphenyl (2E)-3-phenyl-2-propenoate chemical structure, C26H22ClN3O5, CAS 477728-82-8
4-((E)-(((3-Chloro-2-methylanilino)(oxo)acetyl)hydrazono)methyl)-2-methoxyphenyl (2E)-3-phenyl-2-propenoate
CAS 477728-82-8C26H22ClN3O5
4-(2-((2,3-Dichloroanilino)(oxo)AC)carbohydrazonoyl)-2-meo-PH 3-phenylacrylate chemical structure, C25H19Cl2N3O5, CAS 477732-49-3
4-(2-((2,3-Dichloroanilino)(oxo)AC)carbohydrazonoyl)-2-meo-PH 3-phenylacrylate
CAS 477732-49-3C25H19Cl2N3O5
4-(2-((4-Ethylanilino)(oxo)AC)carbohydrazonoyl)-2-methoxyphenyl 3-phenylacrylate chemical structure, C27H25N3O5, CAS 769153-19-7
4-(2-((4-Ethylanilino)(oxo)AC)carbohydrazonoyl)-2-methoxyphenyl 3-phenylacrylate
CAS 769153-19-7C27H25N3O5
4-(2-((4-Ethylanilino)(oxo)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate chemical structure, C26H23N3O4, CAS 764653-65-8
4-(2-((4-Ethylanilino)(oxo)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate
CAS 764653-65-8C26H23N3O4
4-(2-(Anilino(oxo)acetyl)carbohydrazonoyl)-2-methoxyphenyl 3-phenylacrylate chemical structure, C25H21N3O5, CAS 769148-59-6
4-(2-(Anilino(oxo)acetyl)carbohydrazonoyl)-2-methoxyphenyl 3-phenylacrylate
CAS 769148-59-6C25H21N3O5
4-(2-(Oxo(4-toluidino)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate chemical structure, C25H21N3O4, CAS 764653-69-2
4-(2-(Oxo(4-toluidino)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate
CAS 764653-69-2C25H21N3O4
2-Meo-4-(2-((3-methoxyanilino)(oxo)AC)carbohydrazonoyl)phenyl 3-phenylacrylate chemical structure, C26H23N3O6, CAS 769157-15-5
2-Meo-4-(2-((3-methoxyanilino)(oxo)AC)carbohydrazonoyl)phenyl 3-phenylacrylate
CAS 769157-15-5C26H23N3O6
2-Methoxy-4-(2-(oxo(4-toluidino)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate chemical structure, C26H23N3O5, CAS 769153-21-1
2-Methoxy-4-(2-(oxo(4-toluidino)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate
CAS 769153-21-1C26H23N3O5
4-(2-((4-CL-Anilino)(oxo)acetyl)carbohydrazonoyl)-2-meo-phenyl 3-phenylacrylate chemical structure, C25H20ClN3O5, CAS 477728-87-3
4-(2-((4-CL-Anilino)(oxo)acetyl)carbohydrazonoyl)-2-meo-phenyl 3-phenylacrylate
CAS 477728-87-3C25H20ClN3O5
2-Methoxy-4-(2-(oxo(3-toluidino)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate chemical structure, C26H23N3O5, CAS 477728-98-6
2-Methoxy-4-(2-(oxo(3-toluidino)acetyl)carbohydrazonoyl)phenyl 3-phenylacrylate
CAS 477728-98-6C26H23N3O5
2-Meo-4-(2-((4-methoxyanilino)(oxo)AC)carbohydrazonoyl)phenyl 3-phenylacrylate chemical structure, C26H23N3O6, CAS 769147-75-3
2-Meo-4-(2-((4-methoxyanilino)(oxo)AC)carbohydrazonoyl)phenyl 3-phenylacrylate
CAS 769147-75-3C26H23N3O6