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Murcko scaffold

Ring system with 4 rings and 26 atoms

94 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 94
With full pages: 5

Scaffold SMILES

O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2cc(N3CCNCC3)ccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2cc(N3CCNCC3)ccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 94 chemicals

7-(4-Ethylpiperazin-1-yl)-6-fluoro-1-propyl-3-tosylquinolin-4(1H)-one chemical structure, C25H30FN3O3S, CAS 887213-88-9

7-(4-Ethylpiperazin-1-yl)-6-fluoro-1-propyl-3-tosylquinolin-4(1H)-one

CAS 887213-88-9C₂₅H₃₀FN₃O₃S

3-((2,5-Dimethylphenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-propylquinolin-4(1H)-one chemical structure, C26H32FN3O3S, CAS 892781-83-8

3-((2,5-Dimethylphenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-propylquinolin-4(1H)-one

CAS 892781-83-8C₂₆H₃₂FN₃O₃S

1-Butyl-6-fluoro-3-(phenylsulfonyl)-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C26H32FN3O3S, CAS 892759-84-1

1-Butyl-6-fluoro-3-(phenylsulfonyl)-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892759-84-1C₂₆H₃₂FN₃O₃S

6-Fluoro-1-methyl-7-(4-methylpiperazin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C22H24FN3O3S, CAS 887221-28-5

6-Fluoro-1-methyl-7-(4-methylpiperazin-1-yl)-3-tosylquinolin-4(1H)-one

CAS 887221-28-5C₂₂H₂₄FN₃O₃S

3-((3,5-Dimethylphenyl)sulfonyl)-1-ethyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one chemical structure, C25H30FN3O3S, CAS 892788-87-3

3-((3,5-Dimethylphenyl)sulfonyl)-1-ethyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one

CAS 892788-87-3C₂₅H₃₀FN₃O₃S

3-((3-Chlorophenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C22H23ClFN3O3S, CAS 892757-41-4

3-((3-Chlorophenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892757-41-4C₂₂H₂₃ClFN₃O₃S

1-Butyl-3-((3,4-dimethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C26H32FN3O3S, CAS 892767-84-9

1-Butyl-3-((3,4-dimethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892767-84-9C₂₆H₃₂FN₃O₃S

3-((3-Chlorophenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-propylquinolin-4(1H)-one chemical structure, C24H27ClFN3O3S, CAS 892758-17-7

3-((3-Chlorophenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-propylquinolin-4(1H)-one

CAS 892758-17-7C₂₄H₂₇ClFN₃O₃S

3-((4-Ethylphenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-methylquinolin-4(1H)-one chemical structure, C24H28FN3O3S, CAS 892768-92-2

3-((4-Ethylphenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-methylquinolin-4(1H)-one

CAS 892768-92-2C₂₄H₂₈FN₃O₃S

1-Ethyl-3-((4-ethylphenyl)sulfonyl)-6-fluoro-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C26H32FN3O3S, CAS 892769-83-4

1-Ethyl-3-((4-ethylphenyl)sulfonyl)-6-fluoro-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892769-83-4C₂₆H₃₂FN₃O₃S

3-((4-Ethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-1-propylquinolin-4(1H)-one chemical structure, C25H30FN3O3S, CAS 892770-47-7

3-((4-Ethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-1-propylquinolin-4(1H)-one

CAS 892770-47-7C₂₅H₃₀FN₃O₃S

1-Ethyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-3-(4-methoxybenzenesulfonyl)-1,4-dihydroquinolin-4-one chemical structure, C24H28FN3O4S, CAS 892773-15-8

1-Ethyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-3-(4-methoxybenzenesulfonyl)-1,4-dihydroquinolin-4-one

CAS 892773-15-8C₂₄H₂₈FN₃O₄S

3-((4-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C23H25ClFN3O3S, CAS 892775-29-0

3-((4-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892775-29-0C₂₃H₂₅ClFN₃O₃S

6-Fluoro-1-methyl-7-(4-methylpiperazin-1-yl)-3-(phenylsulfonyl)quinolin-4(1H)-one chemical structure, C21H22FN3O3S, CAS 887213-95-8

6-Fluoro-1-methyl-7-(4-methylpiperazin-1-yl)-3-(phenylsulfonyl)quinolin-4(1H)-one

CAS 887213-95-8C₂₁H₂₂FN₃O₃S

1-Ethyl-6-fluoro-3-(phenylsulfonyl)-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C24H28FN3O3S, CAS 887213-97-0

1-Ethyl-6-fluoro-3-(phenylsulfonyl)-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one

CAS 887213-97-0C₂₄H₂₈FN₃O₃S

1-Ethyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-3-(4-methylbenzenesulfonyl)-1,4-dihydroquinolin-4-one chemical structure, C24H28FN3O3S, CAS 887214-02-0

1-Ethyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-3-(4-methylbenzenesulfonyl)-1,4-dihydroquinolin-4-one

CAS 887214-02-0C₂₄H₂₈FN₃O₃S

6-Fluoro-3-((4-methoxyphenyl)sulfonyl)-1-methyl-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C24H28FN3O4S, CAS 887221-30-9

6-Fluoro-3-((4-methoxyphenyl)sulfonyl)-1-methyl-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one

CAS 887221-30-9C₂₄H₂₈FN₃O₄S

1-Ethyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C25H30FN3O4S, CAS 887221-34-3

1-Ethyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-propylpiperazin-1-yl)quinolin-4(1H)-one

CAS 887221-34-3C₂₅H₃₀FN₃O₄S

6-Fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-methylpiperazin-1-yl)-1-propylquinolin-4(1H)-one chemical structure, C24H28FN3O4S, CAS 887221-36-5

6-Fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-methylpiperazin-1-yl)-1-propylquinolin-4(1H)-one

CAS 887221-36-5C₂₄H₂₈FN₃O₄S

1-Butyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-3-tosylquinolin-4(1H)-one chemical structure, C26H32FN3O3S, CAS 892764-24-8

1-Butyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-3-tosylquinolin-4(1H)-one

CAS 892764-24-8C₂₆H₃₂FN₃O₃S

7-(4-Ethylpiperazin-1-yl)-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-1-methylquinolin-4(1H)-one chemical structure, C23H26FN3O4S, CAS 892772-30-4

7-(4-Ethylpiperazin-1-yl)-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-1-methylquinolin-4(1H)-one

CAS 892772-30-4C₂₃H₂₆FN₃O₄S

1-Butyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C25H30FN3O4S, CAS 892774-41-3

1-Butyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892774-41-3C₂₅H₃₀FN₃O₄S

3-((2,5-Dimethylphenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-methylquinolin-4(1H)-one chemical structure, C24H28FN3O3S, CAS 892780-22-2

3-((2,5-Dimethylphenyl)sulfonyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-1-methylquinolin-4(1H)-one

CAS 892780-22-2C₂₄H₂₈FN₃O₃S

3-((2,5-Dimethylphenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one chemical structure, C24H28FN3O3S, CAS 892780-87-9

3-((2,5-Dimethylphenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one

CAS 892780-87-9C₂₄H₂₈FN₃O₃S