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Murcko scaffold

Ring system with 4 rings and 26 atoms

144 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 144
With full pages: 1

Scaffold SMILES

O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2cc(N3CCCCC3)ccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2cc(N3CCCCC3)ccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 144 chemicals

3-(Benzenesulfonyl)-6-fluoro-1-methyl-7-(4-methylpiperidin-1-yl)quinolin-4-one chemical structure, C22H23FN2O3S, CAS 892757-42-5

3-(Benzenesulfonyl)-6-fluoro-1-methyl-7-(4-methylpiperidin-1-yl)quinolin-4-one

CAS 892757-42-5C₂₂H₂₃FN₂O₃S

1-Butyl-3-((2,5-dimethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C27H33FN2O3S, CAS 892782-23-9

1-Butyl-3-((2,5-dimethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892782-23-9C₂₇H₃₃FN₂O₃S

6-Fluoro-1-methyl-7-(4-methylpiperidin-1-yl)-3-(m-tolylsulfonyl)quinolin-4(1H)-one chemical structure, C23H25FN2O3S, CAS 892783-11-8

6-Fluoro-1-methyl-7-(4-methylpiperidin-1-yl)-3-(m-tolylsulfonyl)quinolin-4(1H)-one

CAS 892783-11-8C₂₃H₂₅FN₂O₃S

3-(Benzenesulfonyl)-6-fluoro-7-(piperidin-1-yl)-1-propyl-1,4-dihydroquinolin-4-one chemical structure, C23H25FN2O3S, CAS 892758-72-4

3-(Benzenesulfonyl)-6-fluoro-7-(piperidin-1-yl)-1-propyl-1,4-dihydroquinolin-4-one

CAS 892758-72-4C₂₃H₂₅FN₂O₃S

6-Fluoro-7-(3-methylpiperidin-1-yl)-3-(phenylsulfonyl)-1-propylquinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892758-86-0

6-Fluoro-7-(3-methylpiperidin-1-yl)-3-(phenylsulfonyl)-1-propylquinolin-4(1H)-one

CAS 892758-86-0C₂₄H₂₇FN₂O₃S

1-Butyl-6-fluoro-7-(4-methylpiperidin-1-yl)-3-(phenylsulfonyl)quinolin-4(1H)-one chemical structure, C25H29FN2O3S, CAS 892759-42-1

1-Butyl-6-fluoro-7-(4-methylpiperidin-1-yl)-3-(phenylsulfonyl)quinolin-4(1H)-one

CAS 892759-42-1C₂₅H₂₉FN₂O₃S

1-Ethyl-6-fluoro-7-(3-methylpiperidin-1-yl)-3-(m-tolylsulfonyl)quinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892784-23-5

1-Ethyl-6-fluoro-7-(3-methylpiperidin-1-yl)-3-(m-tolylsulfonyl)quinolin-4(1H)-one

CAS 892784-23-5C₂₄H₂₇FN₂O₃S

6-Fluoro-1-methyl-7-(piperidin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C22H23FN2O3S, CAS 892761-63-6

6-Fluoro-1-methyl-7-(piperidin-1-yl)-3-tosylquinolin-4(1H)-one

CAS 892761-63-6C₂₂H₂₃FN₂O₃S

3-(3,5-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(piperidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C24H27FN2O3S, CAS 892788-47-5

3-(3,5-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(piperidin-1-yl)-1,4-dihydroquinolin-4-one

CAS 892788-47-5C₂₄H₂₇FN₂O₃S

3-((3,5-Dimethylphenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C25H29FN2O3S, CAS 892788-55-5

3-((3,5-Dimethylphenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892788-55-5C₂₅H₂₉FN₂O₃S

3-[(3-Chlorophenyl)sulfonyl]-6-fluoro-1-methyl-7-piperidin-1-ylquinolin-4(1H)-one chemical structure, C21H20ClFN2O3S, CAS 892789-11-6

3-[(3-Chlorophenyl)sulfonyl]-6-fluoro-1-methyl-7-piperidin-1-ylquinolin-4(1H)-one

CAS 892789-11-6C₂₁H₂₀ClFN₂O₃S

3-((3-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(3-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C22H22ClFN2O3S, CAS 892756-08-0

3-((3-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(3-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892756-08-0C₂₂H₂₂ClFN₂O₃S

1-Butyl-6-fluoro-7-(piperidin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C25H29FN2O3S, CAS 892763-69-8

1-Butyl-6-fluoro-7-(piperidin-1-yl)-3-tosylquinolin-4(1H)-one

CAS 892763-69-8C₂₅H₂₉FN₂O₃S

3-((3-Chlorophenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C23H24ClFN2O3S, CAS 892757-06-1

3-((3-Chlorophenyl)sulfonyl)-1-ethyl-6-fluoro-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892757-06-1C₂₃H₂₄ClFN₂O₃S

3-[(3,4-Dimethylphenyl)sulfonyl]-6-fluoro-7-piperidin-1-yl-1-propylquinolin-4(1H)-one chemical structure, C25H29FN2O3S, CAS 892766-72-2

3-[(3,4-Dimethylphenyl)sulfonyl]-6-fluoro-7-piperidin-1-yl-1-propylquinolin-4(1H)-one

CAS 892766-72-2C₂₅H₂₉FN₂O₃S

3-((3,4-Dimethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperidin-1-yl)-1-propylquinolin-4(1H)-one chemical structure, C26H31FN2O3S, CAS 892766-80-2

3-((3,4-Dimethylphenyl)sulfonyl)-6-fluoro-7-(4-methylpiperidin-1-yl)-1-propylquinolin-4(1H)-one

CAS 892766-80-2C₂₆H₃₁FN₂O₃S

1-Butyl-3-(3,4-dimethylbenzenesulfonyl)-6-fluoro-7-(3-methylpiperidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C27H33FN2O3S, CAS 892767-60-1

1-Butyl-3-(3,4-dimethylbenzenesulfonyl)-6-fluoro-7-(3-methylpiperidin-1-yl)-1,4-dihydroquinolin-4-one

CAS 892767-60-1C₂₇H₃₃FN₂O₃S

3-((4-Ethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892768-40-0

3-((4-Ethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892768-40-0C₂₄H₂₇FN₂O₃S

3-((4-Ethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(2-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892768-56-8

3-((4-Ethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(2-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892768-56-8C₂₄H₂₇FN₂O₃S

1-Ethyl-3-((4-ethylphenyl)sulfonyl)-6-fluoro-7-(piperidin-1-yl)quinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892769-20-9

1-Ethyl-3-((4-ethylphenyl)sulfonyl)-6-fluoro-7-(piperidin-1-yl)quinolin-4(1H)-one

CAS 892769-20-9C₂₄H₂₇FN₂O₃S

1-Butyl-3-((4-ethylphenyl)sulfonyl)-6-fluoro-7-(3-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C27H33FN2O3S, CAS 892771-02-7

1-Butyl-3-((4-ethylphenyl)sulfonyl)-6-fluoro-7-(3-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892771-02-7C₂₇H₃₃FN₂O₃S

1-Ethyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C24H27FN2O4S, CAS 892772-69-9

1-Ethyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892772-69-9C₂₄H₂₇FN₂O₄S

3-((4-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one chemical structure, C22H22ClFN2O3S, CAS 892774-81-1

3-((4-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

CAS 892774-81-1C₂₂H₂₂ClFN₂O₃S

1-Butyl-3-((4-chlorophenyl)sulfonyl)-6-fluoro-7-(piperidin-1-yl)quinolin-4(1H)-one chemical structure, C24H26ClFN2O3S, CAS 892777-12-7

1-Butyl-3-((4-chlorophenyl)sulfonyl)-6-fluoro-7-(piperidin-1-yl)quinolin-4(1H)-one

CAS 892777-12-7C₂₄H₂₆ClFN₂O₃S