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Murcko scaffold

Ring system with 2 rings and 12 atoms

47 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
47
With full pages
3
Scaffold SMILES

c1ccc(Sc2ccn[nH]2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2ccn[nH]2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

5-[(4-Chlorophenyl)sulfanyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide chemical structure, C12H12ClN3OS, CAS 303987-96-4
5-[(4-Chlorophenyl)sulfanyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide
CAS 303987-96-4C12H12ClN3OS
Methyl 2-{[4-cyano-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate chemical structure, C14H10F3N3O2S, CAS 318239-35-9
Methyl 2-{[4-cyano-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate
CAS 318239-35-9C14H10F3N3O2S
5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile chemical structure, C12H7ClF3N3S, CAS 318239-36-0
5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile
CAS 318239-36-0C12H7ClF3N3S
5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile chemical structure, C12H7ClF3N3S, CAS 318239-38-2
5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile
CAS 318239-38-2C12H7ClF3N3S
(1-Methyl-3-(trifluoromethyl)-5-{[3-(trifluoro-methyl)phenyl]sulfanyl}-1H-pyrazol-4-yl)methanol chemical structure, C13H10F6N2OS, CAS 318239-53-1
(1-Methyl-3-(trifluoromethyl)-5-{[3-(trifluoro-methyl)phenyl]sulfanyl}-1H-pyrazol-4-yl)methanol
CAS 318239-53-1C13H10F6N2OS
[1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl acetate chemical structure, C14H13F3N2O2S, CAS 318239-55-3
[1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl acetate
CAS 318239-55-3C14H13F3N2O2S
(1-Methyl-3-(trifluoromethyl)-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazol-4-yl)methyl acetate chemical structure, C15H12F6N2O2S, CAS 957010-42-3
(1-Methyl-3-(trifluoromethyl)-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazol-4-yl)methyl acetate
CAS 957010-42-3C15H12F6N2O2S
5-(4-Bromophenylthio)-4-(hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole chemical structure, C12H10BrF3N2OS, CAS 318239-56-4
5-(4-Bromophenylthio)-4-(hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole
CAS 318239-56-4C12H10BrF3N2OS
[5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl acetate chemical structure, C14H12BrF3N2O2S, CAS 318239-58-6
[5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl acetate
CAS 318239-58-6C14H12BrF3N2O2S
[5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl acetate chemical structure, C14H12ClF3N2O2S, CAS 318239-59-7
[5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl acetate
CAS 318239-59-7C14H12ClF3N2O2S
{5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl}methyl 2,2-dichloroacetate chemical structure, C14H10BrCl2F3N2O2S, CAS 957010-41-2
{5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl}methyl 2,2-dichloroacetate
CAS 957010-41-2C14H10BrCl2F3N2O2S
[5-(4-Chlorophenyl)sulfanyl-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl 2,2-dichloroacetate chemical structure, C14H10Cl3F3N2O2S, CAS 318239-60-0
[5-(4-Chlorophenyl)sulfanyl-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl 2,2-dichloroacetate
CAS 318239-60-0C14H10Cl3F3N2O2S
1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile chemical structure, C12H8F3N3S, CAS 318284-60-5
1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile
CAS 318284-60-5C12H8F3N3S
[5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 2-chloroacetate chemical structure, C14H11ClF4N2O2S, CAS 318469-26-0
[5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 2-chloroacetate
CAS 318469-26-0C14H11ClF4N2O2S
[5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl propionate chemical structure, C15H14F4N2O2S, CAS 956705-45-6
[5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl propionate
CAS 956705-45-6C15H14F4N2O2S
[5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl propionate chemical structure, C15H14ClF3N2O2S, CAS 955962-82-0
[5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl propionate
CAS 955962-82-0C15H14ClF3N2O2S
Methyl 2-[(4-formyl-1,3-dimethyl-1H-pyrazol-5-yl)-sulfanyl]benzenecarboxylate chemical structure, C14H14N2O3S, CAS 852700-50-6
Methyl 2-[(4-formyl-1,3-dimethyl-1H-pyrazol-5-yl)-sulfanyl]benzenecarboxylate
CAS 852700-50-6C14H14N2O3S
5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde chemical structure, C12H8BrF3N2OS, CAS 321848-45-7
5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde
CAS 321848-45-7C12H8BrF3N2OS
5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde chemical structure, C12H8ClF3N2OS, CAS 321533-70-4
5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde
CAS 321533-70-4C12H8ClF3N2OS
[5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol chemical structure, C12H10ClF3N2OS, CAS 318239-52-0
[5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol
CAS 318239-52-0C12H10ClF3N2OS
5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde chemical structure, C12H8F4N2OS, CAS 321848-46-8
5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde
CAS 321848-46-8C12H8F4N2OS
(5-((4-Fluorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol chemical structure, C12H10F4N2OS, CAS 318239-65-5
(5-((4-Fluorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol
CAS 318239-65-5C12H10F4N2OS
Methyl 2-{[4-formyl-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate chemical structure, C14H11F3N2O3S, CAS 321553-50-8
Methyl 2-{[4-formyl-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate
CAS 321553-50-8C14H11F3N2O3S
[1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol chemical structure, C12H11F3N2OS, CAS 318239-51-9
[1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol
CAS 318239-51-9C12H11F3N2OS