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Murcko scaffold

Spiro(chroman-2,4'-piperidin)-4-one scaffold

120 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
120
With full pages
4
Scaffold SMILES

O=C1CC2(CCNCC2)Oc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro(chroman-2,4'-piperidin)-4-one page
Murcko scaffold O=C1CC2(CCNCC2)Oc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 120 chemicals

N-Methylspiro[2H-1-benzopyran-2,4'-piperidine]4(3H)-one chemical structure, C14H17NO2, CAS 62756-24-5
N-Methylspiro[2H-1-benzopyran-2,4'-piperidine]4(3H)-one
CAS 62756-24-5C14H17NO2
Spiro(chroman-2,4'-piperidin)-4-one chemical structure, C13H15NO2, CAS 136081-84-0
Spiro(chroman-2,4'-piperidin)-4-one
CAS 136081-84-0C13H15NO2
Ethyl 4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-1'-carboxylate chemical structure, C16H19NO4, CAS 742094-83-3
Ethyl 4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-1'-carboxylate
CAS 742094-83-3C16H19NO4
Spiro(1-benzopyran-2,4'-piperidin)-4(3H)-one--hydrogen chloride (1/1) chemical structure, C13H16ClNO2, CAS 159635-39-9
Spiro(1-benzopyran-2,4'-piperidin)-4(3H)-one--hydrogen chloride (1/1)
CAS 159635-39-9C13H16ClNO2
tert-Butyl 6-bromo-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate chemical structure, C18H22BrNO4, CAS 690632-38-3
tert-Butyl 6-bromo-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
CAS 690632-38-3C18H22BrNO4
6-Bromospiro[chromene-2,4'-piperidin]-4(3H)-one trifluoroacetate chemical structure, C15H15BrF3NO4, CAS 690632-09-8
6-Bromospiro[chromene-2,4'-piperidin]-4(3H)-one trifluoroacetate
CAS 690632-09-8C15H15BrF3NO4
6-Bromospiro[chroman-2,4'-piperidin]-4-one chemical structure, C13H14BrNO2, CAS 690632-08-7
6-Bromospiro[chroman-2,4'-piperidin]-4-one
CAS 690632-08-7C13H14BrNO2
1'-Acetyl-6-hydroxyspiro[chromane-2,4'-piperidin]-4-one chemical structure, C15H17NO4, CAS 897771-16-3
1'-Acetyl-6-hydroxyspiro[chromane-2,4'-piperidin]-4-one
CAS 897771-16-3C15H17NO4
1'-Acetylspiro[chroman-2,4'-piperidin]-4-one chemical structure, C15H17NO3, CAS 203797-50-6
1'-Acetylspiro[chroman-2,4'-piperidin]-4-one
CAS 203797-50-6C15H17NO3
1'-(2-Methylpropanoyl)-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one chemical structure, C17H21NO3, CAS 887466-59-3
1'-(2-Methylpropanoyl)-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one
CAS 887466-59-3C17H21NO3
1'-(3,3-Dimethylbutanoyl)-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one chemical structure, C19H25NO3, CAS 887466-61-7
1'-(3,3-Dimethylbutanoyl)-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one
CAS 887466-61-7C19H25NO3
1'-(2-Ethylbutanoyl)spiro[chroman-2,4'-piperidin]-4-one chemical structure, C19H25NO3, CAS 898405-65-7
1'-(2-Ethylbutanoyl)spiro[chroman-2,4'-piperidin]-4-one
CAS 898405-65-7C19H25NO3
1'-(3-Chloropropanoyl)spiro[chroman-2,4'-piperidin]-4-one chemical structure, C16H18ClNO3, CAS 887466-68-4
1'-(3-Chloropropanoyl)spiro[chroman-2,4'-piperidin]-4-one
CAS 887466-68-4C16H18ClNO3
1'-(3-Chloro-2,2-dimethylpropanoyl)spiro[chroman-2,4'-piperidin]-4-one chemical structure, C18H22ClNO3, CAS 896332-80-2
1'-(3-Chloro-2,2-dimethylpropanoyl)spiro[chroman-2,4'-piperidin]-4-one
CAS 896332-80-2C18H22ClNO3
Ethyl 2-oxo-2-(4-oxospiro[chroman-2,4'-piperidin]-1'-yl)acetate chemical structure, C17H19NO5, CAS 877811-32-0
Ethyl 2-oxo-2-(4-oxospiro[chroman-2,4'-piperidin]-1'-yl)acetate
CAS 877811-32-0C17H19NO5
Ethyl 4-oxo-4-{4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-1'-yl}butanoate chemical structure, C19H23NO5, CAS 887468-09-9
Ethyl 4-oxo-4-{4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-1'-yl}butanoate
CAS 887468-09-9C19H23NO5
4-Oxo-4-{4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-1'-yl}butanoic acid chemical structure, C17H19NO5, CAS 877811-34-2
4-Oxo-4-{4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-1'-yl}butanoic acid
CAS 877811-34-2C17H19NO5
5-Oxo-5-(4-oxospiro[chroman-2,4'-piperidin]-1'-yl)pentanoic acid chemical structure, C18H21NO5, CAS 877811-35-3
5-Oxo-5-(4-oxospiro[chroman-2,4'-piperidin]-1'-yl)pentanoic acid
CAS 877811-35-3C18H21NO5
1'-Mesylspiro[chroman-2,4'-piperidin]-4-one chemical structure, C14H17NO4S, CAS 877811-36-4
1'-Mesylspiro[chroman-2,4'-piperidin]-4-one
CAS 877811-36-4C14H17NO4S
1'-(Ethanesulfonyl)-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one chemical structure, C15H19NO4S, CAS 877811-37-5
1'-(Ethanesulfonyl)-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one
CAS 877811-37-5C15H19NO4S
N-tert-Butyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxamide chemical structure, C18H24N2O3, CAS 896335-72-1
N-tert-Butyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxamide
CAS 896335-72-1C18H24N2O3
1-(2-Chloroacetyl)-3,4-dihydrospiro[1-benzopyran-2,4-piperidin]-4-one chemical structure, C15H16ClNO3, CAS 896332-66-4
1-(2-Chloroacetyl)-3,4-dihydrospiro[1-benzopyran-2,4-piperidin]-4-one
CAS 896332-66-4C15H16ClNO3
N-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)methanesulfonamide chemical structure, C14H18N2O4S, CAS 136081-93-1
N-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)methanesulfonamide
CAS 136081-93-1C14H18N2O4S
tert-Butyl 8-fluoro-4-oxospiro[3H-chromene-2,4'-piperidine]-1'-carboxylate chemical structure, C18H22FNO4, CAS 1024605-91-1
tert-Butyl 8-fluoro-4-oxospiro[3H-chromene-2,4'-piperidine]-1'-carboxylate
CAS 1024605-91-1C18H22FNO4