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Murcko scaffold

1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one scaffold

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
32
With full pages
1
Scaffold SMILES

O=C1NC2(CCNCC2)Nc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one page
Murcko scaffold O=C1NC2(CCNCC2)Nc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

1'-Methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C13H17N3O, CAS 438621-93-3
1'-Methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 438621-93-3C13H17N3O
6'-Bromo-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C12H14BrN3O, CAS 1016817-08-5
6'-Bromo-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1016817-08-5C12H14BrN3O
1-(2-Chloropropanoyl)-6'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C16H20ClN3O2, CAS 1016817-26-7
1-(2-Chloropropanoyl)-6'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1016817-26-7C16H20ClN3O2
7'-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C12H14ClN3O, CAS 1016818-09-9
7'-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1016818-09-9C12H14ClN3O
tert-Butyl 4'-oxo-3',4'-dihydro-1H,1'H-spiro(piperidine-4,2'-quinazoline)-1-carboxylate chemical structure, C17H23N3O3, CAS 1000356-55-7
tert-Butyl 4'-oxo-3',4'-dihydro-1H,1'H-spiro(piperidine-4,2'-quinazoline)-1-carboxylate
CAS 1000356-55-7C17H23N3O3
tert-Butyl 6'-bromo-4'-oxo-3',4'-dihydro-1'H-spiro[piperidine-4,2'-quinazoline]-1-carboxylate chemical structure, C17H22BrN3O3, CAS 947015-75-0
tert-Butyl 6'-bromo-4'-oxo-3',4'-dihydro-1'H-spiro[piperidine-4,2'-quinazoline]-1-carboxylate
CAS 947015-75-0C17H22BrN3O3
6'-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C12H14ClN3O, CAS 731762-03-1
6'-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 731762-03-1C12H14ClN3O
1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C12H15N3O, CAS 202826-52-6
1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 202826-52-6C12H15N3O
1,1'-Dimethylspiro[3H-quinazoline-2,4'-piperidine]-4-one chemical structure, C14H19N3O, CAS 1090021-29-6
1,1'-Dimethylspiro[3H-quinazoline-2,4'-piperidine]-4-one
CAS 1090021-29-6C14H19N3O
7'-Chloro-1'-ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H18ClN3O, CAS 1325304-52-6
7'-Chloro-1'-ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1325304-52-6C14H18ClN3O
1'-Ethyl-6'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H18FN3O, CAS 1325305-94-9
1'-Ethyl-6'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1325305-94-9C14H18FN3O
1'-Ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H19N3O, CAS 1325304-82-2
1'-Ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1325304-82-2C14H19N3O
7'-Chloro-1'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C13H16ClN3O, CAS 1325307-04-7
7'-Chloro-1'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1325307-04-7C13H16ClN3O
1'-Ethyl-7'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H18FN3O, CAS 1351399-01-3
1'-Ethyl-7'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1351399-01-3C14H18FN3O
6'-Chloro-1'-ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H18ClN3O, CAS 1351398-15-6
6'-Chloro-1'-ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1351398-15-6C14H18ClN3O
1'-Ethyl-6'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C15H21N3O, CAS 1351398-03-2
1'-Ethyl-6'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1351398-03-2C15H21N3O
7'-Fluoro-1'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C13H16FN3O, CAS 1351398-43-0
7'-Fluoro-1'-methyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1351398-43-0C13H16FN3O
3-Propyl-1'-prop-2-ynylspiro[1H-quinazoline-2,4'-piperidine]-4-one chemical structure, C18H23N3O, CAS 1333906-78-7
3-Propyl-1'-prop-2-ynylspiro[1H-quinazoline-2,4'-piperidine]-4-one
CAS 1333906-78-7C18H23N3O
3-(2-Methylpropyl)-1'-prop-2-ynylspiro[1H-quinazoline-2,4'-piperidine]-4-one chemical structure, C19H25N3O, CAS 1333528-69-0
3-(2-Methylpropyl)-1'-prop-2-ynylspiro[1H-quinazoline-2,4'-piperidine]-4-one
CAS 1333528-69-0C19H25N3O
7'-Chloro-1-(prop-2-yn-1-yl)-3',4'-dihydro-1'H-spiro[piperidine-4,2'-quinazoline]-4'-one chemical structure, C15H16ClN3O, CAS 1333858-85-7
7'-Chloro-1-(prop-2-yn-1-yl)-3',4'-dihydro-1'H-spiro[piperidine-4,2'-quinazoline]-4'-one
CAS 1333858-85-7C15H16ClN3O
7'-Fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C12H14FN3O, CAS 1355181-90-6
7'-Fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1355181-90-6C12H14FN3O
6'-Fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C12H14FN3O, CAS 1355195-80-0
6'-Fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1355195-80-0C12H14FN3O
6',7'-Dimethoxy-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H19N3O3, CAS 1355219-01-0
6',7'-Dimethoxy-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1355219-01-0C14H19N3O3
1',6'-Dimethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one chemical structure, C14H19N3O, CAS 1355175-14-2
1',6'-Dimethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
CAS 1355175-14-2C14H19N3O