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Murcko scaffold

1-Benzyl-1,2,3,4-tetrahydroquinazoline-2,4-dione scaffold

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
36
With full pages
9
Scaffold SMILES

O=c1[nH]c(=O)n(Cc2ccccc2)c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyl-1,2,3,4-tetrahydroquinazoline-2,4-dione page
Murcko scaffold O=c1[nH]c(=O)n(Cc2ccccc2)c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

1-(2-Fluorobenzyl)-3-methylquinazoline-2,4(1H,3H)-dione chemical structure, C16H13FN2O2, CAS 634166-84-0
1-(2-Fluorobenzyl)-3-methylquinazoline-2,4(1H,3H)-dione
CAS 634166-84-0C16H13FN2O2
2,4(1H,3H)-Quinazolinedione, 3-(dimethylamino)-1-(phenylmethyl)- chemical structure, C17H17N3O2, CAS 87296-61-5
2,4(1H,3H)-Quinazolinedione, 3-(dimethylamino)-1-(phenylmethyl)-
CAS 87296-61-5C17H17N3O2
3-Ethyl-1-(2-methylbenzyl)quinazoline-2,4(1H,3H)-dione chemical structure, C18H18N2O2, CAS 886155-70-0
3-Ethyl-1-(2-methylbenzyl)quinazoline-2,4(1H,3H)-dione
CAS 886155-70-0C18H18N2O2
3-Ethyl-1-[(3-methylphenyl)methyl]quinazoline-2,4-dione chemical structure, C18H18N2O2, CAS 886155-48-2
3-Ethyl-1-[(3-methylphenyl)methyl]quinazoline-2,4-dione
CAS 886155-48-2C18H18N2O2
3-Ethyl-1-(4-nitrobenzyl)quinazoline-2,4(1H,3H)-dione chemical structure, C17H15N3O4, CAS 886155-40-4
3-Ethyl-1-(4-nitrobenzyl)quinazoline-2,4(1H,3H)-dione
CAS 886155-40-4C17H15N3O4
3-Ethyl-1-(3-nitrobenzyl)quinazoline-2,4(1H,3H)-dione chemical structure, C17H15N3O4, CAS 886155-63-1
3-Ethyl-1-(3-nitrobenzyl)quinazoline-2,4(1H,3H)-dione
CAS 886155-63-1C17H15N3O4
N-Butyl-4-(1-(2-methylbenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)butanamide chemical structure, C24H29N3O3, CAS 899786-51-7
N-Butyl-4-(1-(2-methylbenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)butanamide
CAS 899786-51-7C24H29N3O3
N-(3-Methoxypropyl)-4-{1-[(3-nitrophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}butanamide chemical structure, C23H26N4O6, CAS 899788-40-0
N-(3-Methoxypropyl)-4-{1-[(3-nitrophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}butanamide
CAS 899788-40-0C23H26N4O6
N-(3-Methoxypropyl)-3-{1-[(3-nitrophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}propanamide chemical structure, C22H24N4O6, CAS 899919-71-2
N-(3-Methoxypropyl)-3-{1-[(3-nitrophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}propanamide
CAS 899919-71-2C22H24N4O6
N-(2-Methoxyethyl)-4-(1-(3-nitrobenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)butanamide chemical structure, C22H24N4O6, CAS 899786-43-7
N-(2-Methoxyethyl)-4-(1-(3-nitrobenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)butanamide
CAS 899786-43-7C22H24N4O6
1-Benzyl-3-ethylquinazoline-2,4(1H,3H)-dione chemical structure, C17H16N2O2, CAS 924875-81-0
1-Benzyl-3-ethylquinazoline-2,4(1H,3H)-dione
CAS 924875-81-0C17H16N2O2
3-Ethyl-1-(4-methylbenzyl)quinazoline-2,4(1H,3H)-dione chemical structure, C18H18N2O2, CAS 941520-85-0
3-Ethyl-1-(4-methylbenzyl)quinazoline-2,4(1H,3H)-dione
CAS 941520-85-0C18H18N2O2
1-Benzyl-3-ethyl-6,7-dimethoxyquinazoline-2,4(1H,3H)-dione chemical structure, C19H20N2O4, CAS 924857-96-5
1-Benzyl-3-ethyl-6,7-dimethoxyquinazoline-2,4(1H,3H)-dione
CAS 924857-96-5C19H20N2O4
3-Ethyl-6,7-dimethoxy-1-(4-methylbenzyl)quinazoline-2,4(1H,3H)-dione chemical structure, C20H22N2O4, CAS 924870-36-0
3-Ethyl-6,7-dimethoxy-1-(4-methylbenzyl)quinazoline-2,4(1H,3H)-dione
CAS 924870-36-0C20H22N2O4
4-{2,4-Dioxo-1-[(2,4,6-trimethylphenyl)methyl]-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(3-methoxypropyl)butanamide chemical structure, C26H33N3O4, CAS 899788-41-1
4-{2,4-Dioxo-1-[(2,4,6-trimethylphenyl)methyl]-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(3-methoxypropyl)butanamide
CAS 899788-41-1C26H33N3O4
4-(2,4-Dioxo-1-(2,4,6-trimethylbenzyl)-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-methoxyethyl)butanamide chemical structure, C25H31N3O4, CAS 899786-49-3
4-(2,4-Dioxo-1-(2,4,6-trimethylbenzyl)-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-methoxyethyl)butanamide
CAS 899786-49-3C25H31N3O4
N-Butyl-4-{1-[(2,5-dimethylphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}butanamide chemical structure, C25H31N3O3, CAS 899786-63-1
N-Butyl-4-{1-[(2,5-dimethylphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}butanamide
CAS 899786-63-1C25H31N3O3
4-(1-(2-Cyanobenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-methoxyethyl)butanamide chemical structure, C23H24N4O4, CAS 899786-47-1
4-(1-(2-Cyanobenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-methoxyethyl)butanamide
CAS 899786-47-1C23H24N4O4
5-{1-[(2-Chloro-4-fluorophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(propan-2-yl)pentanamide chemical structure, C23H25ClFN3O3, CAS 1040675-68-0
5-{1-[(2-Chloro-4-fluorophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(propan-2-yl)pentanamide
CAS 1040675-68-0C23H25ClFN3O3
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(3-methylbutyl)pentanamide chemical structure, C27H33N3O5, CAS 1040677-14-2
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(3-methylbutyl)pentanamide
CAS 1040677-14-2C27H33N3O5
5-{1-[(2-Chlorophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(propan-2-yl)pentanamide chemical structure, C23H26ClN3O3, CAS 1040677-64-2
5-{1-[(2-Chlorophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(propan-2-yl)pentanamide
CAS 1040677-64-2C23H26ClN3O3
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(propan-2-yl)pentanamide chemical structure, C25H29N3O5, CAS 1040677-68-6
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(propan-2-yl)pentanamide
CAS 1040677-68-6C25H29N3O5
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(2-methylpropyl)pentanamide chemical structure, C26H31N3O5, CAS 1021263-43-3
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-(2-methylpropyl)pentanamide
CAS 1021263-43-3C26H31N3O5
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-propylpentanamide chemical structure, C25H29N3O5, CAS 1021251-70-6
5-{1-[(5-Formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}-N-propylpentanamide
CAS 1021251-70-6C25H29N3O5