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Murcko scaffold

Ring system with 6 rings and 42 atoms

112 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
42
Chemicals
112
With full pages
6
Scaffold SMILES

O=C(Nc1ccn(C2CCC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)n1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccn(C2CCC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)n1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 112 chemicals

N-[1-[(2R,4S,5R)-4-Hydroxy-5-(trityloxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide chemical structure, C35H31N3O5, CAS 105862-10-0
N-[1-[(2R,4S,5R)-4-Hydroxy-5-(trityloxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
CAS 105862-10-0C35H31N3O5
N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine chemical structure, C37H35N3O7, CAS 67219-55-0
N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
CAS 67219-55-0C37H35N3O7
N-[1-[(2R,4S,5R)-4-Hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide chemical structure, C36H33N3O6, CAS 60920-99-2
N-[1-[(2R,4S,5R)-4-Hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
CAS 60920-99-2C36H33N3O6
N-[1-[5-[[Bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-hydroxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide chemical structure, C37H35N3O7, CAS 128435-26-7
N-[1-[5-[[Bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-hydroxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
CAS 128435-26-7C37H35N3O7
Cytidine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite) chemical structure, C46H52N5O8P, CAS 102212-98-6
Cytidine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite)
CAS 102212-98-6C46H52N5O8P
5'-O-DMT-N4-Bz-2'-F-dC chemical structure, C37H34FN3O7, CAS 146954-77-0
5'-O-DMT-N4-Bz-2'-F-dC
CAS 146954-77-0C37H34FN3O7
2'-F-Bz-dC Phosphoramidite chemical structure, C46H51FN5O8P, CAS 161442-19-9
2'-F-Bz-dC Phosphoramidite
CAS 161442-19-9C46H51FN5O8P
Orb1907347 chemical structure, C51H58F3N6O10P, CAS 165381-54-4
Orb1907347
CAS 165381-54-4C51H58F3N6O10P
Orb1907348 chemical structure, C42H41F3N4O9, CAS 1053243-01-8
Orb1907348
CAS 1053243-01-8C42H41F3N4O9
5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine chemical structure, C43H49N3O8Si, CAS 81256-87-3
5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine
CAS 81256-87-3C43H49N3O8Si
Bz-rC Phosphoramidite chemical structure, C52H66N5O9PSi, CAS 118380-84-0
Bz-rC Phosphoramidite
CAS 118380-84-0C52H66N5O9PSi
N-Benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-5-methylcytidine chemical structure, C38H37N3O7, CAS 104579-03-5
N-Benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-5-methylcytidine
CAS 104579-03-5C38H37N3O7
Cytidine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, 3'-(hydrogen butanedioate) chemical structure, C41H39N3O10, CAS 74405-44-0
Cytidine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, 3'-(hydrogen butanedioate)
CAS 74405-44-0C41H39N3O10
2-TFA-AE MeC(Bz) amidite chemical structure, C51H58F3N6O10P, CAS 911110-81-1
2-TFA-AE MeC(Bz) amidite
CAS 911110-81-1C51H58F3N6O10P
5-Me-DMT-2'-O-Me-C(Bz)-CE Phosphoramidite chemical structure, C48H56N5O9P, CAS 166593-57-3
5-Me-DMT-2'-O-Me-C(Bz)-CE Phosphoramidite
CAS 166593-57-3C48H56N5O9P
N-(1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide chemical structure, C37H35N3O8, CAS 81246-76-6
N-(1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
CAS 81246-76-6C37H35N3O8
N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine chemical structure, C37H35N3O7, CAS 86234-45-9
N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine
CAS 86234-45-9C37H35N3O7
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-(4-methoxybenzoyl)cytidine chemical structure, C38H37N3O8, CAS 68892-40-0
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-(4-methoxybenzoyl)cytidine
CAS 68892-40-0C38H37N3O8
(2R,3S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-YL)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite chemical structure, C46H52N5O8P, CAS 152697-18-2
(2R,3S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-YL)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
CAS 152697-18-2C46H52N5O8P
DMT-2'-OMe-Bz-C chemical structure, C38H37N3O8, CAS 110764-74-4
DMT-2'-OMe-Bz-C
CAS 110764-74-4C38H37N3O8
2'-OMe-Bz-C Phosphoramidite chemical structure, C47H54N5O9P, CAS 110764-78-8
2'-OMe-Bz-C Phosphoramidite
CAS 110764-78-8C47H54N5O9P
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-Cytidine chemical structure, C43H49N3O8Si, CAS 81246-78-8
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-Cytidine
CAS 81246-78-8C43H49N3O8Si
N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine chemical structure, C36H33N3O7, CAS 72409-15-5
N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine
CAS 72409-15-5C36H33N3O7
5'-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite chemical structure, C44H51N4O8P, CAS 84416-83-1
5'-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite
CAS 84416-83-1C44H51N4O8P