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Murcko scaffold

RefChem:381794 scaffold

23 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
23
With full pages
1
Scaffold SMILES

O=C(CSC1=NCCN1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RefChem:381794 page
Murcko scaffold O=C(CSC1=NCCN1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

1-(3,4-Dichlorophenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)sulfanyl)ethan-1-one--hydrogen bromide (1/1) chemical structure, C11H11BrCl2N2OS, CAS 33983-16-3
1-(3,4-Dichlorophenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)sulfanyl)ethan-1-one--hydrogen bromide (1/1)
CAS 33983-16-3C11H11BrCl2N2OS
Dita chemical structure, C11H10Cl2N2OS, CAS 36066-03-2
Dita
CAS 36066-03-2C11H10Cl2N2OS
2-Imidazoline, 2-phenacylthio-, hydrochloride chemical structure, C11H12ClN2OS-, CAS 74038-86-1
2-Imidazoline, 2-phenacylthio-, hydrochloride
CAS 74038-86-1C11H12ClN2OS-
RefChem:381794 chemical structure, C11H12N2OS, CAS 32188-94-6
RefChem:381794
CAS 32188-94-6C11H12N2OS
2-(4,5-Dihydro-1H-imidazol-2-ylsulfanyl)-1-phenylethanone acetate (1:1) chemical structure, C13H16N2O3S, CAS 6333-73-9
2-(4,5-Dihydro-1H-imidazol-2-ylsulfanyl)-1-phenylethanone acetate (1:1)
CAS 6333-73-9C13H16N2O3S
2-Imidazoline, 2-(p-nitrophenacylthio)- chemical structure, C11H11N3O3S, CAS 36065-80-2
2-Imidazoline, 2-(p-nitrophenacylthio)-
CAS 36065-80-2C11H11N3O3S
Ethanone, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-1-(4-methoxyphenyl)-, monohydrochloride chemical structure, C12H15ClN2O2S, CAS 160518-34-3
Ethanone, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-1-(4-methoxyphenyl)-, monohydrochloride
CAS 160518-34-3C12H15ClN2O2S
Ethanone, 1-(3-bromo-4-methoxyphenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C12H14BrClN2O2S, CAS 160518-35-4
Ethanone, 1-(3-bromo-4-methoxyphenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-35-4C12H14BrClN2O2S
Ethanone, 1-(5-bromo-2-hydroxyphenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C11H12BrClN2O2S, CAS 160518-36-5
Ethanone, 1-(5-bromo-2-hydroxyphenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-36-5C11H12BrClN2O2S
Ethanone, 1-(3-chloro-4-(pentyloxy)phenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C16H22Cl2N2O2S, CAS 160518-37-6
Ethanone, 1-(3-chloro-4-(pentyloxy)phenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-37-6C16H22Cl2N2O2S
Ethanone, 1-(3-chloro-4-(hexyloxy)phenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C17H24Cl2N2O2S, CAS 160518-38-7
Ethanone, 1-(3-chloro-4-(hexyloxy)phenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-38-7C17H24Cl2N2O2S
Acetamide, N-(2-chloro-4-(((4,5-dihydro-1H-imidazol-2-yl)thio)acetyl)phenyl)-, monohydrochloride chemical structure, C13H15Cl2N3O2S, CAS 160518-39-8
Acetamide, N-(2-chloro-4-(((4,5-dihydro-1H-imidazol-2-yl)thio)acetyl)phenyl)-, monohydrochloride
CAS 160518-39-8C13H15Cl2N3O2S
Acetamide, N-(4-(((4,5-dihydro-1H-imidazol-2-yl)thio)acetyl)-2-nitrophenyl)-, monohydrochloride chemical structure, C13H15ClN4O4S, CAS 160518-40-1
Acetamide, N-(4-(((4,5-dihydro-1H-imidazol-2-yl)thio)acetyl)-2-nitrophenyl)-, monohydrochloride
CAS 160518-40-1C13H15ClN4O4S
N-(4-(2-((4,5-Dihydro-1H-imidazol-2-yl)thio)acetyl)-2-nitrophenyl)acetamide chemical structure, C13H14N4O4S, CAS 791037-17-7
N-(4-(2-((4,5-Dihydro-1H-imidazol-2-yl)thio)acetyl)-2-nitrophenyl)acetamide
CAS 791037-17-7C13H14N4O4S
Ethanone, 1-(3-chloro-4-methoxyphenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C13H16Cl2N2O2S, CAS 160518-45-6
Ethanone, 1-(3-chloro-4-methoxyphenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-45-6C13H16Cl2N2O2S
Ethanone, 1-(3-chloro-4-propoxyphenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C15H20Cl2N2O2S, CAS 160518-46-7
Ethanone, 1-(3-chloro-4-propoxyphenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-46-7C15H20Cl2N2O2S
Ethanone, 1-(4-butoxy-3-chlorophenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C16H22Cl2N2O2S, CAS 160518-47-8
Ethanone, 1-(4-butoxy-3-chlorophenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-47-8C16H22Cl2N2O2S
Ethanone, 1-(3-chloro-4-(pentyloxy)phenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C17H24Cl2N2O2S, CAS 160518-48-9
Ethanone, 1-(3-chloro-4-(pentyloxy)phenyl)-2-((4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 160518-48-9C17H24Cl2N2O2S
Ethanone, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-1-(4-propoxyphenyl)-, monohydrochloride chemical structure, C14H19ClN2O2S, CAS 130623-16-4
Ethanone, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-1-(4-propoxyphenyl)-, monohydrochloride
CAS 130623-16-4C14H19ClN2O2S
Ethanone, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-1-(4-methoxy-3-nitrophenyl)-, monohydrochloride chemical structure, C12H14ClN3O4S, CAS 130623-21-1
Ethanone, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-1-(4-methoxy-3-nitrophenyl)-, monohydrochloride
CAS 130623-21-1C12H14ClN3O4S
Ethanone, 1-(4-amino-3-nitrophenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride chemical structure, C11H13ClN4O3S, CAS 130623-24-4
Ethanone, 1-(4-amino-3-nitrophenyl)-2-((4,5-dihydro-1H-imidazol-2-yl)thio)-, monohydrochloride
CAS 130623-24-4C11H13ClN4O3S
2-[(1-Acetyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-1-phenylethan-1-one chemical structure, C13H14N2O2S, CAS 60498-94-4
2-[(1-Acetyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-1-phenylethan-1-one
CAS 60498-94-4C13H14N2O2S
5G29Hxc57Y chemical structure, C11H12BrN3O3S, CAS 36066-17-8
5G29Hxc57Y
CAS 36066-17-8C11H12BrN3O3S