Murcko scaffold
N-Benzylthiophene-2-carboxamide scaffold
128 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 128
- With full pages
- 28
Scaffold SMILES
O=C(NCc1ccccc1)c1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 128 chemicals
Thiophene-2-carboxamide, N-benzyl-N-tert-butyl-
CAS 5357-07-3C16H19NOS
N-Benzylthiophene-2-carboxamide
CAS 10354-43-5C12H11NOS
![N-[(4-Methoxyphenyl)methyl]thiophene-2-carboxamide chemical structure, C13H13NO2S, CAS 5345-10-8](/s/IQZQDGIWGKOBJY-UHFFFAOYSA-N.svg)
N-[(4-Methoxyphenyl)methyl]thiophene-2-carboxamide
CAS 5345-10-8C13H13NO2S
N-Benzyl-N-ethylthiophene-2-carboxamide
CAS 346691-41-6C14H15NOS
N-Benzyl-N-(propan-2-yl)thiophene-2-carboxamide
CAS 346691-42-7C15H17NOS
N-Benzyl-N-methylthiophene-2-carboxamide
CAS 5245-93-2C13H13NOS
![N-[(4-Sulfamoylphenyl)methyl]thiophene-2-carboxamide chemical structure, C12H12N2O3S2, CAS 301302-00-1](/s/QCAWUTTUCXCEMW-UHFFFAOYSA-N.svg)
N-[(4-Sulfamoylphenyl)methyl]thiophene-2-carboxamide
CAS 301302-00-1C12H12N2O3S2
![N-[(4-Methylphenyl)methyl]thiophene-2-carboxamide chemical structure, C13H13NOS, CAS 329939-05-1](/s/NUQVSGQAALWHLJ-UHFFFAOYSA-N.svg)
N-[(4-Methylphenyl)methyl]thiophene-2-carboxamide
CAS 329939-05-1C13H13NOS
N-(2-Methoxybenzyl)thiophene-2-carboxamide
CAS 339088-18-5C13H13NO2S
![Ethyl 2-amino-5-[benzyl(methyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C17H20N2O3S, CAS 346714-20-3](/s/BMMKVEMHZSMESR-UHFFFAOYSA-N.svg)
Ethyl 2-amino-5-[benzyl(methyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 346714-20-3C17H20N2O3S
![3-Methyl-N-[(4-methylphenyl)methyl]thiophene-2-carboxamide chemical structure, C14H15NOS, CAS 445007-73-8](/s/HEADITVSXYFDJR-UHFFFAOYSA-N.svg)
3-Methyl-N-[(4-methylphenyl)methyl]thiophene-2-carboxamide
CAS 445007-73-8C14H15NOS
![5-(3-Hydroxy-3-methylbut-1-ynyl)-N-[(4-methylphenyl)methyl]thiophene-2-carboxamide chemical structure, C18H19NO2S, CAS 695221-63-7](/s/BJUUQGSRXAGNBS-UHFFFAOYSA-N.svg)
5-(3-Hydroxy-3-methylbut-1-ynyl)-N-[(4-methylphenyl)methyl]thiophene-2-carboxamide
CAS 695221-63-7C18H19NO2S
5-Methyl-N-(4-methylbenzyl)-2-thiophenecarboxamide
CAS 444936-40-7C14H15NOS
N-(4-Chlorobenzyl)-3-methylthiophene-2-carboxamide
CAS 445002-21-1C13H12ClNOS
![N-[(2-Fluorophenyl)methyl]thiophene-2-carboxamide chemical structure, C12H10FNOS, CAS 717855-66-8](/s/OSVGMRRNTWTZGC-UHFFFAOYSA-N.svg)
N-[(2-Fluorophenyl)methyl]thiophene-2-carboxamide
CAS 717855-66-8C12H10FNOS
![4-Bromo-5-ethyl-N-[(4-sulfamoylphenyl)methyl]thiophene-2-carboxamide chemical structure, C14H15BrN2O3S2, CAS 774589-46-7](/s/HOLZKPQNGDBMMT-UHFFFAOYSA-N.svg)
4-Bromo-5-ethyl-N-[(4-sulfamoylphenyl)methyl]thiophene-2-carboxamide
CAS 774589-46-7C14H15BrN2O3S2
![5-Bromo-N-[(3,4-dimethoxyphenyl)methyl]thiophene-2-carboxamide chemical structure, C14H14BrNO3S, CAS 717868-25-2](/s/DPACVHCSUFMTLC-UHFFFAOYSA-N.svg)
5-Bromo-N-[(3,4-dimethoxyphenyl)methyl]thiophene-2-carboxamide
CAS 717868-25-2C14H14BrNO3S
![N-[(4-Fluorophenyl)methyl]thiophene-2-carboxamide chemical structure, C12H10FNOS, CAS 331434-74-3](/s/MXQYPMNMVLKJSO-UHFFFAOYSA-N.svg)
N-[(4-Fluorophenyl)methyl]thiophene-2-carboxamide
CAS 331434-74-3C12H10FNOS
![N-[(2-Methoxyphenyl)methyl]-3-methylthiophene-2-carboxamide chemical structure, C14H15NO2S, CAS 734545-42-7](/s/FYUUWIPPTAJUFC-UHFFFAOYSA-N.svg)
N-[(2-Methoxyphenyl)methyl]-3-methylthiophene-2-carboxamide
CAS 734545-42-7C14H15NO2S
N-Benzyl-5-ethyl-4-methylthiophene-2-carboxamide
CAS 852033-87-5C15H17NOS
N-(2-Chlorobenzyl)-2-thiophenecarboxamide
CAS 446854-88-2C12H10ClNOS
![Methyl 3-(4-isopropylphenyl)-3-[(2-thienylcarbonyl)amino]propanoate chemical structure, C18H21NO3S, CAS 477858-90-5](/s/HPDFXUGVJBDBDZ-UHFFFAOYSA-N.svg)
Methyl 3-(4-isopropylphenyl)-3-[(2-thienylcarbonyl)amino]propanoate
CAS 477858-90-5C18H21NO3S
![Phenyl[(thien-2-ylcarbonyl)amino]acetic acid chemical structure, C13H11NO3S, CAS 1008670-87-8](/s/JQDFNCZLEHZUNZ-UHFFFAOYSA-N.svg)
Phenyl[(thien-2-ylcarbonyl)amino]acetic acid
CAS 1008670-87-8C13H11NO3S
N-Benzyl-N-(2-cyanoethyl)thiophene-2-carboxamide
CAS 700347-75-7C15H14N2OS
- N-(1-Phenylethyl)thiophene-2-carboxamide313516-35-7C13H13NOS
- 5-Methyl-N-[1-(4-propylphenyl)ethyl]thiophene-2-carboxamide445232-82-6C17H21NOS
- N-[1-(3,4-Dimethylphenyl)ethyl]-5-methylthiophene-2-carboxamide492434-19-2C16H19NOS
- N-[1-(4-Bromophenyl)ethyl]thiophene-2-carboxamide709009-87-0C13H12BrNOS
- N-[1-(4-Ethoxyphenyl)ethyl]-5-ethylthiophene-2-carboxamide774588-11-3C17H21NO2S
- N-[1-(3,4-Dimethylphenyl)ethyl]thiophene-2-carboxamide444999-96-6C15H17NOS
- Methyl 2-amino-5-(benzylcarbamoyl)-4-methylthiophene-3-carboxylate915916-25-5C15H16N2O3S
- 3-(4-Ethoxy-3-methoxy-phenyl)-3-[(thiophene-2-carbonyl)-amino]-propionic acid436087-15-9C17H19NO5S
- Methyl 3-(3,4-dimethoxyphenyl)-3-[(2-thienylcarbonyl)amino]propanoate478249-90-0C17H19NO5S
- 4,5-Dibromo-N-[1-(3-methoxyphenyl)ethyl]thiophene-2-carboxamide438233-43-3C14H13Br2NO2S
- N-[1-(4-Ethylphenyl)ethyl]thiophene-2-carboxamide445005-47-0C15H17NOS
- 3-(4-Isopropylphenyl)-3-[(2-thienylcarbonyl)amino]propanoic acid861207-47-8C17H19NO3S
- N-[1-(3,4-Dimethoxyphenyl)-3-hydroxypropyl]thiophene-2-carboxamide866149-48-6C16H19NO4S
- 5-Bromo-N-[(4-fluorophenyl)methyl]thiophene-2-carboxamide250383-88-1C12H9BrFNOS
- 4,5-Dibromo-N-[1-(4-ethoxyphenyl)ethyl]thiophene-2-carboxamide438236-48-7C15H15Br2NO2S
- 4-[(Thiophen-2-ylformamido)methyl]benzoic acid392716-12-0C13H11NO3S
- 2-Thienyl-N-((3-(trifluoromethoxy)phenyl)methyl)formamide1024174-11-5C13H10F3NO2S
- N-[(3-Methylphenyl)methyl]thiophene-2-carboxamide710318-41-5C13H13NOS
- N-[1-(4-Fluorophenyl)ethyl]thiophene-2-carboxamide796057-68-6C13H12FNOS
- N-(1-(2-Methoxyphenyl)ethyl)thiophene-2-carboxamide851623-46-6C14H15NO2S
- N-[(4-Chlorophenyl)methyl]thiophene-2-carboxamide446854-83-7C12H10ClNOS
- 5-Chloro-N-[1-(4-methoxyphenyl)ethyl]thiophene-2-carboxamide894648-05-6C14H14ClNO2S
- N-[1-(4-Methylphenyl)propyl]thiophene-2-carboxamide894635-48-4C15H17NOS
- 5-Chloro-N-[1-(3,4-dimethoxyphenyl)ethyl]thiophene-2-carboxamide894649-11-7C15H16ClNO3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(OCc1ccccc1)N1CCCC161 chemicals
O=C(NCc1ccco1)c1ccccc158 chemicals
O=C(Cc1cccs1)Nc1ccccc141 chemicals
O=C(NCC1CCCO1)c1ccccc138 chemicals
O=C(NCC1CCCN1)c1ccccc138 chemicals
O=C(Cc1ccccc1)Nc1nccs137 chemicals
O=S(=O)(NCc1ccco1)c1ccccc136 chemicals
O=S(=O)(NCC1CCCO1)c1ccccc134 chemicals
O=C(NCc1ccccc1)c1ccco130 chemicals
c1ccc(CNCc2ccco2)cc128 chemicals![Scaffold O=C(NCc1ccccc1)c1ccc[nH]1](/scaffold/PSYQATYJXPGBDC-UHFFFAOYSA-N/structure.svg)
O=C(NCc1ccccc1)c1ccc[nH]125 chemicals
O=C(Cc1ccccc1)Nc1nncs124 chemicals