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Murcko scaffold

Ring system with 4 rings and 19 atoms

44 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
19
Chemicals
44
With full pages
4
Scaffold SMILES

C1=CC(c2ccccc2)n2c(nc3ccccc32)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1=CC(c2ccccc2)n2c(nc3ccccc32)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

Pyrimido(1,2-a)benzimidazole, 1,4-dihydro-4-(4-chlorophenyl)-2-methyl- chemical structure, C17H14ClN3, CAS 169132-72-3
Pyrimido(1,2-a)benzimidazole, 1,4-dihydro-4-(4-chlorophenyl)-2-methyl-
CAS 169132-72-3C17H14ClN3
Pyrimido(1,2-a)benzimidazole, 1,4-dihydro-4-(4-methoxyphenyl)-2-methyl- chemical structure, C18H17N3O, CAS 169132-73-4
Pyrimido(1,2-a)benzimidazole, 1,4-dihydro-4-(4-methoxyphenyl)-2-methyl-
CAS 169132-73-4C18H17N3O
Benzenamine, N,N-dimethyl-4-(2-methyl-1,4-dihydropyrimido(1,2-a)benzimidazol-4-yl)- chemical structure, C19H20N4, CAS 169132-74-5
Benzenamine, N,N-dimethyl-4-(2-methyl-1,4-dihydropyrimido(1,2-a)benzimidazol-4-yl)-
CAS 169132-74-5C19H20N4
Methyl 2-methyl-4-phenyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C19H17N3O2, CAS 403847-36-9
Methyl 2-methyl-4-phenyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 403847-36-9C19H17N3O2
Ethyl 4-(3-hydroxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C20H19N3O3, CAS 727405-75-6
Ethyl 4-(3-hydroxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-75-6C20H19N3O3
Ethyl 4-(3,4-dihydroxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C20H19N3O4, CAS 727405-85-8
Ethyl 4-(3,4-dihydroxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-85-8C20H19N3O4
Ethyl 2-methyl-4-(2,3,4-trimethoxyphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C23H25N3O5, CAS 727405-88-1
Ethyl 2-methyl-4-(2,3,4-trimethoxyphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-88-1C23H25N3O5
Ethyl 4-(3,4-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C22H23N3O4, CAS 727405-84-7
Ethyl 4-(3,4-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-84-7C22H23N3O4
Ethyl 4-(2,3-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C22H23N3O4, CAS 727405-92-7
Ethyl 4-(2,3-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-92-7C22H23N3O4
4-(4-Isopropylphenyl)-N,2-dimethyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxamide chemical structure, C22H24N4O, CAS 720668-02-0
4-(4-Isopropylphenyl)-N,2-dimethyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxamide
CAS 720668-02-0C22H24N4O
Methyl 2-methyl-4-(3-methylphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C20H19N3O2, CAS 777867-83-1
Methyl 2-methyl-4-(3-methylphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 777867-83-1C20H19N3O2
Ethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C23H25N3O5, CAS 727405-89-2
Ethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-89-2C23H25N3O5
Methyl 4-(4-hydroxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C19H17N3O3, CAS 777867-82-0
Methyl 4-(4-hydroxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 777867-82-0C19H17N3O3
Methyl 4-(4-methoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C20H19N3O3, CAS 704877-27-0
Methyl 4-(4-methoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 704877-27-0C20H19N3O3
Ethyl 4-(2-fluorophenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C20H18FN3O2, CAS 727405-80-3
Ethyl 4-(2-fluorophenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727405-80-3C20H18FN3O2
Methyl 2-methyl-4-(4-methylphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C20H19N3O2, CAS 777867-81-9
Methyl 2-methyl-4-(4-methylphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 777867-81-9C20H19N3O2
Methyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C22H23N3O5, CAS 777867-86-4
Methyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 777867-86-4C22H23N3O5
Methyl 4-(2-fluorophenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C19H16FN3O2, CAS 777879-32-0
Methyl 4-(2-fluorophenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 777879-32-0C19H16FN3O2
Propan-2-yl 4-[4-(dimethylamino)phenyl]-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C23H26N4O2, CAS 727672-29-9
Propan-2-yl 4-[4-(dimethylamino)phenyl]-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 727672-29-9C23H26N4O2
Methyl 4-(3,4-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C21H21N3O4, CAS 879078-80-5
Methyl 4-(3,4-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 879078-80-5C21H21N3O4
Ethyl 4-(3-fluorophenyl)-2-propyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C22H22FN3O2, CAS 879600-48-3
Ethyl 4-(3-fluorophenyl)-2-propyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 879600-48-3C22H22FN3O2
Ethyl 4-(3,4-dimethoxyphenyl)-2-propyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C24H27N3O4, CAS 879600-98-3
Ethyl 4-(3,4-dimethoxyphenyl)-2-propyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 879600-98-3C24H27N3O4
Methyl 4-(4-hydroxy-3,5-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C21H21N3O5, CAS 879045-85-9
Methyl 4-(4-hydroxy-3,5-dimethoxyphenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 879045-85-9C21H21N3O5
Isopropyl 4-(3-chlorophenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate chemical structure, C21H20ClN3O2, CAS 879078-89-4
Isopropyl 4-(3-chlorophenyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
CAS 879078-89-4C21H20ClN3O2