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Murcko scaffold

1H,2H,3H-Pyrazolo[3,4-b]pyridin-3-one scaffold

68 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
68
With full pages
21
Scaffold SMILES

O=c1[nH][nH]c2ncccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H,2H,3H-Pyrazolo[3,4-b]pyridin-3-one page
Murcko scaffold O=c1[nH][nH]c2ncccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 68 chemicals

4,6-Dimethyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C8H9N3O, CAS 28491-67-0
4,6-Dimethyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
CAS 28491-67-0C8H9N3O
1H,2H,3H-Pyrazolo[3,4-b]pyridin-3-one chemical structure, C6H5N3O, CAS 2942-43-0
1H,2H,3H-Pyrazolo[3,4-b]pyridin-3-one
CAS 2942-43-0C6H5N3O
4,6-Dimethyl-1-(pentan-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-ol chemical structure, C13H19N3O, CAS 694517-41-4
4,6-Dimethyl-1-(pentan-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-ol
CAS 694517-41-4C13H19N3O
1-Methyl-1H,2H,3H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C7H7N3O, CAS 2942-45-2
1-Methyl-1H,2H,3H-pyrazolo[3,4-b]pyridin-3-one
CAS 2942-45-2C7H7N3O
1-Heptan-4-yl-4,6-dimethyl-2H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C15H23N3O, CAS 713098-52-3
1-Heptan-4-yl-4,6-dimethyl-2H-pyrazolo[3,4-b]pyridin-3-one
CAS 713098-52-3C15H23N3O
4,6-Bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol chemical structure, C8H3F6N3O, CAS 89990-37-4
4,6-Bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol
CAS 89990-37-4C8H3F6N3O
1,4,6-Trimethyl-1H,2H,3H-pyrazolo(3,4-b)pyridin-3-one chemical structure, C9H11N3O, CAS 71290-70-5
1,4,6-Trimethyl-1H,2H,3H-pyrazolo(3,4-b)pyridin-3-one
CAS 71290-70-5C9H11N3O
4,6-Dimethyl-1-(pentan-2-yl)-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C13H19N3O, CAS 573939-28-3
4,6-Dimethyl-1-(pentan-2-yl)-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
CAS 573939-28-3C13H19N3O
1-(Heptan-2-yl)-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-ol chemical structure, C15H23N3O, CAS 718601-82-2
1-(Heptan-2-yl)-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-ol
CAS 718601-82-2C15H23N3O
1-Hexan-2-yl-4,6-dimethyl-2H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C14H21N3O, CAS 727674-10-4
1-Hexan-2-yl-4,6-dimethyl-2H-pyrazolo[3,4-b]pyridin-3-one
CAS 727674-10-4C14H21N3O
4,6-Dimethyl-1-octan-2-yl-2H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C16H25N3O, CAS 848683-89-6
4,6-Dimethyl-1-octan-2-yl-2H-pyrazolo[3,4-b]pyridin-3-one
CAS 848683-89-6C16H25N3O
1-(Chloroacetyl)-4,6-dimethyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C10H10ClN3O2, CAS 853574-46-6
1-(Chloroacetyl)-4,6-dimethyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
CAS 853574-46-6C10H10ClN3O2
6-Trifluoromethyl-1H-pyrazolo-[3,4-b]pyridin-3-ol chemical structure, C7H4F3N3O, CAS 191478-63-4
6-Trifluoromethyl-1H-pyrazolo-[3,4-b]pyridin-3-ol
CAS 191478-63-4C7H4F3N3O
4-Methyl-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridine-6-carboxylic acid chemical structure, C8H7N3O3, CAS 862273-50-5
4-Methyl-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
CAS 862273-50-5C8H7N3O3
6-Methyl-1H-pyrazolo[3,4-b]pyridin-3-ol chemical structure, C7H7N3O, CAS 28491-63-6
6-Methyl-1H-pyrazolo[3,4-b]pyridin-3-ol
CAS 28491-63-6C7H7N3O
Methyl 1,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C10H11N3O3, CAS 71290-72-7
Methyl 1,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 71290-72-7C10H11N3O3
1,2-Dihydro-1,6-dimethyl-4-(trifluoromethyl)-3H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C9H8F3N3O, CAS 71290-73-8
1,2-Dihydro-1,6-dimethyl-4-(trifluoromethyl)-3H-pyrazolo[3,4-b]pyridin-3-one
CAS 71290-73-8C9H8F3N3O
6-Methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol chemical structure, C8H6F3N3O, CAS 72567-47-6
6-Methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol
CAS 72567-47-6C8H6F3N3O
Ethyl 4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate chemical structure, C11H13N3O3, CAS 88101-45-5
Ethyl 4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
CAS 88101-45-5C11H13N3O3
1-Propyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one chemical structure, C9H11N3O, CAS 1016230-29-7
1-Propyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one
CAS 1016230-29-7C9H11N3O
1-Butyl-2H-pyrazolo[3,4-b]pyridin-3-one chemical structure, C10H13N3O, CAS 1016230-30-0
1-Butyl-2H-pyrazolo[3,4-b]pyridin-3-one
CAS 1016230-30-0C10H13N3O
Methyl 3-{1,4,6-trimethyl-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridin-5-yl}propanoate chemical structure, C13H17N3O3, CAS 1049873-43-9
Methyl 3-{1,4,6-trimethyl-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridin-5-yl}propanoate
CAS 1049873-43-9C13H17N3O3
1,6-Dimethyl-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C9H9N3O3, CAS 1050885-37-4
1,6-Dimethyl-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 1050885-37-4C9H9N3O3
4-(tert-Butyl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid chemical structure, C11H13N3O3, CAS 1144484-03-6
4-(tert-Butyl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
CAS 1144484-03-6C11H13N3O3