Murcko scaffold
2-(1-Piperidinyl)-4(3H)-pyrimidinone scaffold
66 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 66
- With full pages
- 7
Scaffold SMILES
O=c1ccnc(N2CCCCC2)[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccnc(N2CCCCC2)[nH]1](/scaffold/RCLPPVGRWSZZNX-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 66 chemicals
2-(1-Piperidinyl)-4(3H)-pyrimidinone
CAS 19810-81-2C9H13N3O
Ethyl 4-hydroxy-2-(piperidin-1-yl)pyrimidine-5-carboxylate
CAS 25693-43-0C12H17N3O3
6-Hydroxy-2-(1-piperidinyl)-4(3H)-pyrimidinone
CAS 65399-52-2C9H13N3O2
4-Hydroxy-2-(piperidin-1-yl)pyrimidine-5-carboxylic acid
CAS 1023815-72-6C10H13N3O3
![N-(2-Methoxyethyl)-2-[4-methyl-6-oxo-2-piperidino-1(6H)-pyrimidinyl]acetamide chemical structure, C15H24N4O3, CAS 1340840-92-7](/s/PIMLKTPOGLLWFE-UHFFFAOYSA-N.svg)
N-(2-Methoxyethyl)-2-[4-methyl-6-oxo-2-piperidino-1(6H)-pyrimidinyl]acetamide
CAS 1340840-92-7C15H24N4O3
1-(5-(Methylsulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid
CAS 1708268-32-9C11H15N3O5S
2-(4-Aminopiperidin-1-yl)-5-(methylsulfonyl)pyrimidin-4(3H)-one
CAS 1708428-01-6C10H16N4O3S
2-(4-Aminopiperidin-1-yl)-3,6-dimethylpyrimidin-4(3H)-one
CAS 1708080-28-7C11H18N4O
1-(1,4-Dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid
CAS 1708268-49-8C12H17N3O3
2-(4-Aminopiperidin-1-yl)-6-ethyl-3-methylpyrimidin-4(3H)-one
CAS 1713639-51-0C12H20N4O
1-(4-Ethyl-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid
CAS 1707372-74-4C13H19N3O3
1-(1,4,5-Trimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid
CAS 1708080-31-2C13H19N3O3
2-(4-Aminopiperidin-1-yl)-3-methyl-6-(trifluoromethyl)pyrimidin-4(3H)-one
CAS 1707394-42-0C11H15F3N4O
1-(1-Methyl-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid
CAS 1707566-39-9C12H14F3N3O3
1-(4-(Methoxymethyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid
CAS 1708080-30-1C13H19N3O4
4-Hydroxy-2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid
CAS 1355231-80-9C10H13N3O4
1-(5-(Methylsulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid
CAS 1710844-94-2C11H15N3O5S
2-(3-Aminopiperidin-1-yl)-3,6-dimethylpyrimidin-4(3H)-one
CAS 1708370-47-1C11H18N4O
1-(1,4-Dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid
CAS 1713462-39-5C12H17N3O3
2-(3-Aminopiperidin-1-yl)-6-ethyl-3-methylpyrimidin-4(3H)-one
CAS 1707394-40-8C12H20N4O
1-(4-Ethyl-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid
CAS 1707594-61-3C13H19N3O3
2-(3-Aminopiperidin-1-yl)-3,5,6-trimethylpyrimidin-4(3H)-one
CAS 1708370-48-2C12H20N4O
1-(1,4,5-Trimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid
CAS 1708268-53-4C13H19N3O3
2-(3-Aminopiperidin-1-yl)-3-methyl-6-(trifluoromethyl)pyrimidin-4(3H)-one
CAS 1710195-22-4C11H15F3N4O
- 1-(1-Methyl-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid1707372-75-5C12H14F3N3O3
- 1-(4-(Methoxymethyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid1708268-51-2C13H19N3O4
- tert-Butyl (1-(4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidin-4-yl)carbamate1821308-46-6C15H22Cl2N4O3
- N-[1-(5-Chloro-4-cyano-1,6-dihydro-1-methyl-6-oxo-2-pyrimidinyl)-4-piperidinyl]carbamic acid 1,1-dimethylethyl ester1821308-66-0C16H22ClN5O3
- N-[1-(4-Chloro-1-ethyl-1,6-dihydro-6-oxo-2-pyrimidinyl)-4-piperidinyl]carbamic acid 1,1-dimethylethyl ester1821308-52-4C16H25ClN4O3
- N-[1-[4-Chloro-1,6-dihydro-1-(3-methoxypropyl)-6-oxo-2-pyrimidinyl]-4-piperidinyl]carbamic acid 1,1-dimethylethyl ester1821308-62-6C18H29ClN4O4
- 6-Methyl-2-(piperidin-1-yl)pyrimidin-4-ol42487-69-4C10H15N3O
- 5-Ethyl-6-methyl-2-(piperidin-1-yl)pyrimidin-4(1H)-one727390-78-5C12H19N3O
- 4-Hydroxy-6-methyl-2-(piperidin-1-yl)pyrimidine-5-carbaldehyde23948-50-7C11H15N3O2
- 4-Amino-5-nitroso-2-piperidin-1-yl-1H-pyrimidin-6-one90644-27-2C9H13N5O2
- N-Methyl-N-[(4-methyl-6-oxo-2-piperidin-1-yl-1H-pyrimidin-5-yl)methyl]nitrous amide93002-45-0C12H19N5O2
- 5,6-Dimethyl-2-(1-piperidinyl)-4(3H)-pyrimidinone23947-75-3C11H17N3O
- 6-Amino-2-piperidin-1-ylpyrimidin-4(3H)-one76750-95-3C9H14N4O
- 6-Methyl-2-(4-methylpiperidin-1-yl)pyrimidin-4(3H)-one1147211-55-9C11H17N3O
- 1-(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid873208-73-2C11H15N3O3
- 1,6-Dihydro-4-hydroxy-6-oxo-2-(1-piperidinyl)-5-pyrimidinecarboxaldehyde102873-12-1C10H13N3O3
- 6-Amino-2-(4-methylpiperidin-1-yl)pyrimidin-4(3H)-one1020243-94-0C10H16N4O
- 6-Amino-2-(3-methyl-1-piperidinyl)-4(3H)-pyrimidinone1020243-95-1C10H16N4O
- 1-(4-Amino-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxamide1030670-35-9C10H15N5O2
- Ethyl 1-(4-amino-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylate1030520-54-7C12H18N4O3
- 1-(4-Ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid1082392-86-6C12H17N3O3
- 6-Methyl-2-(3-methylpiperidin-1-yl)pyrimidin-4(3H)-one702668-96-0C11H17N3O
- Ethyl 1-(4-hydroxy-6-methylpyrimidin-2-yl)piperidine-4-carboxylate1029792-08-2C13H19N3O3
- 1-(4-Hydroxy-6-methylpyrimidin-2-yl)piperidine-3-carboxylic acid1216234-17-1C11H15N3O3
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Same ring framework with different atoms or bond orders
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