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Murcko scaffold

Ring system with 2 rings and 18 atoms

12 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
12
With full pages
4
Scaffold SMILES

O=C(CNC(=O)c1cn[nH]c1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNC(=O)c1cn[nH]c1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

5-Chloro-N-[2-(4-isopropylanilino)-2-oxoethyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide chemical structure, C17H21ClN4O2, CAS 955976-68-8
5-Chloro-N-[2-(4-isopropylanilino)-2-oxoethyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide
CAS 955976-68-8C17H21ClN4O2
5-Chloro-N-[2-(2,6-dimethylanilino)-2-oxoethyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide chemical structure, C16H19ClN4O2, CAS 956372-10-4
5-Chloro-N-[2-(2,6-dimethylanilino)-2-oxoethyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide
CAS 956372-10-4C16H19ClN4O2
5-Chloro-N-[2-(4-methoxyanilino)-2-oxoethyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide chemical structure, C15H17ClN4O3, CAS 956501-59-0
5-Chloro-N-[2-(4-methoxyanilino)-2-oxoethyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide
CAS 956501-59-0C15H17ClN4O3
5-Chloro-N-[2-[(3-methoxyphenyl)amino]-2-oxoethyl]-N,3-dimethyl-1-(2-methylpropyl)-1H-pyrazole-4-carboxamide chemical structure, C19H25ClN4O3, CAS 1172749-37-9
5-Chloro-N-[2-[(3-methoxyphenyl)amino]-2-oxoethyl]-N,3-dimethyl-1-(2-methylpropyl)-1H-pyrazole-4-carboxamide
CAS 1172749-37-9C19H25ClN4O3
Methyl 2-(2-(3-methoxy-1-methyl-1H-pyrazole-4-carboxamido)acetamido)benzoate chemical structure, C16H18N4O5, CAS 1251658-28-2
Methyl 2-(2-(3-methoxy-1-methyl-1H-pyrazole-4-carboxamido)acetamido)benzoate
CAS 1251658-28-2C16H18N4O5
N-(2-((4-Fluoro-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide chemical structure, C15H14F4N4O3, CAS 1251574-01-2
N-(2-((4-Fluoro-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
CAS 1251574-01-2C15H14F4N4O3
N-(3-Methanesulfonamidophenyl)-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)formamido]acetamide chemical structure, C15H19N5O5S, CAS 1251609-98-9
N-(3-Methanesulfonamidophenyl)-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)formamido]acetamide
CAS 1251609-98-9C15H19N5O5S
N-(2-((4-Butylphenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide chemical structure, C18H24N4O3, CAS 1351597-27-7
N-(2-((4-Butylphenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
CAS 1351597-27-7C18H24N4O3
Butyl 4-(2-(3-methoxy-1-methyl-1H-pyrazole-4-carboxamido)acetamido)benzoate chemical structure, C19H24N4O5, CAS 1351648-79-7
Butyl 4-(2-(3-methoxy-1-methyl-1H-pyrazole-4-carboxamido)acetamido)benzoate
CAS 1351648-79-7C19H24N4O5
N-(2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide chemical structure, C16H20N4O3, CAS 1351607-80-1
N-(2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
CAS 1351607-80-1C16H20N4O3
N-(2-((4-Bromo-3-methylphenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide chemical structure, C15H17BrN4O3, CAS 1351588-93-6
N-(2-((4-Bromo-3-methylphenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
CAS 1351588-93-6C15H17BrN4O3
N-(2-((4-Cyanophenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide chemical structure, C15H15N5O3, CAS 1351589-42-8
N-(2-((4-Cyanophenyl)amino)-2-oxoethyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
CAS 1351589-42-8C15H15N5O3