Murcko scaffold
Ring system with 2 rings and 14 atoms
19 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 19
- With full pages
- 3
Scaffold SMILES
O=S(=O)(c1ccsc1)N1CCCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 19 of 19 chemicals
4-(Piperidin-1-ylsulfonyl)thiophene-2-carboxylic acid
CAS 893782-30-4C10H13NO4S2
4-((4-Methylpiperidin-1-yl)sulfonyl)thiophene-2-carboxylic acid
CAS 893782-34-8C11H15NO4S2
3-(Piperidin-1-ylsulfonyl)thiophene-2-carboxylic acid
CAS 923697-76-1C10H13NO4S2
![1-[(2,5-Dichlorothien-3-yl)sulfonyl]piperidine-4-carboxylic acid chemical structure, C10H11Cl2NO4S2, CAS 923791-21-3](/s/VGQHHDOIAUKMIO-UHFFFAOYSA-N.svg)
1-[(2,5-Dichlorothien-3-yl)sulfonyl]piperidine-4-carboxylic acid
CAS 923791-21-3C10H11Cl2NO4S2
![1-[(2,5-Dimethylthien-3-yl)sulfonyl]piperidine-4-carboxylic acid chemical structure, C12H17NO4S2, CAS 923734-79-6](/s/WEXVAWMZLHJQNN-UHFFFAOYSA-N.svg)
1-[(2,5-Dimethylthien-3-yl)sulfonyl]piperidine-4-carboxylic acid
CAS 923734-79-6C12H17NO4S2
![1-[(2,5-Dichlorothiophen-3-yl)sulfonyl]piperidine-3-carboxylic acid chemical structure, C10H11Cl2NO4S2, CAS 923810-07-5](/s/ZAVLSGJNCZPQRC-UHFFFAOYSA-N.svg)
1-[(2,5-Dichlorothiophen-3-yl)sulfonyl]piperidine-3-carboxylic acid
CAS 923810-07-5C10H11Cl2NO4S2
![1-[(2,5-Dimethylthien-3-yl)sulfonyl]piperidine-3-carboxylic acid chemical structure, C12H17NO4S2, CAS 923744-29-0](/s/QNLBIMHPVLRDPT-UHFFFAOYSA-N.svg)
1-[(2,5-Dimethylthien-3-yl)sulfonyl]piperidine-3-carboxylic acid
CAS 923744-29-0C12H17NO4S2
![Methyl 3-[(4-carbamoylpiperidin-1-yl)sulfonyl]thiophene-2-carboxylate chemical structure, C12H16N2O5S2, CAS 895261-95-7](/s/GGUIFWZZYLTIAY-UHFFFAOYSA-N.svg)
Methyl 3-[(4-carbamoylpiperidin-1-yl)sulfonyl]thiophene-2-carboxylate
CAS 895261-95-7C12H16N2O5S2
3-(1-Piperidinylsulfonyl)-N-2-propyn-1-yl-2-thiophenecarboxamide
CAS 1015400-02-8C13H16N2O3S2
![3-[(4-Hydroxypiperidin-1-yl)sulfonyl]thiophene-2-carboxylic acid chemical structure, C10H13NO5S2, CAS 1097001-67-6](/s/KNGWFBSRXWIMHH-UHFFFAOYSA-N.svg)
3-[(4-Hydroxypiperidin-1-yl)sulfonyl]thiophene-2-carboxylic acid
CAS 1097001-67-6C10H13NO5S2
![3-{[2-(2-Hydroxyethyl)piperidin-1-yl]sulfonyl}thiophene-2-carboxylic acid chemical structure, C12H17NO5S2, CAS 1096935-50-0](/s/FGOCPFKNBYZDTF-UHFFFAOYSA-N.svg)
3-{[2-(2-Hydroxyethyl)piperidin-1-yl]sulfonyl}thiophene-2-carboxylic acid
CAS 1096935-50-0C12H17NO5S2
![3-{[4-(Hydroxymethyl)piperidin-1-yl]sulfonyl}thiophene-2-carboxylic acid chemical structure, C11H15NO5S2, CAS 1097060-68-8](/s/OKDMAASSNQVVPZ-UHFFFAOYSA-N.svg)
3-{[4-(Hydroxymethyl)piperidin-1-yl]sulfonyl}thiophene-2-carboxylic acid
CAS 1097060-68-8C11H15NO5S2
![3-[(2,6-Dimethylpiperidin-1-yl)sulfonyl]thiophene-2-carboxylic acid chemical structure, C12H17NO4S2, CAS 1096977-62-6](/s/GFTJFVJVDXRQCG-UHFFFAOYSA-N.svg)
3-[(2,6-Dimethylpiperidin-1-yl)sulfonyl]thiophene-2-carboxylic acid
CAS 1096977-62-6C12H17NO4S2
1-((2,5-Dichlorothiophen-3-yl)sulfonyl)piperidin-4-ol
CAS 1154142-00-3C9H11Cl2NO3S2
Methyl 3-((4-carbamoylpiperidin-1-yl)sulfonyl)-5-chlorothiophene-2-carboxylate
CAS 1212060-33-7C12H15ClN2O5S2
3-(4-Aminopiperidine-1-sulfonyl)thiophene-2-carboxylic acid
CAS 1158451-36-5C10H14N2O4S2
Methyl 3-((4-((2-(methylamino)-2-oxoethyl)sulfonyl)piperidin-1-yl)sulfonyl)thiophene-2-carboxylate
CAS 1448063-38-4C14H20N2O7S3
N-(1-Cyano-2-methoxyethyl)-3-(piperidine-1-sulfonyl)thiophene-2-carboxamide
CAS 1797248-68-0C14H19N3O4S2
![N-(1-Cyanoethyl)-3-[2-(2-hydroxyethyl)piperidin-1-yl]sulfonylthiophene-2-carboxamide chemical structure, C15H21N3O4S2, CAS 2178689-39-7](/s/QTVGDCXZKPOFNA-UHFFFAOYSA-N.svg)
N-(1-Cyanoethyl)-3-[2-(2-hydroxyethyl)piperidin-1-yl]sulfonylthiophene-2-carboxamide
CAS 2178689-39-7C15H21N3O4S2
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(Cn2cccn2)cc1271 chemicals
c1ccc(CN2CCCC2)cc1172 chemicals
O=S(=O)(c1ccccc1)N1CCCC1146 chemicals
c1ccc(Cn2ccnc2)cc1107 chemicals![Scaffold c1ccc(N=c2[nH]ccs2)cc1](/scaffold/OGVGQYZRJXSMGC-UHFFFAOYSA-N/structure.svg)
c1ccc(N=c2[nH]ccs2)cc198 chemicals
O=C1NC(=S)SC1=Cc1ccccc186 chemicals
O=C(c1ccccc1)N1CCCC186 chemicals
O=S(=O)(c1ccccc1)n1ccnc184 chemicals![Scaffold O=C(c1ccccc1)c1cc[nH]c1](/scaffold/DSNSKSWTLGZGAN-UHFFFAOYSA-N/structure.svg)
O=C(c1ccccc1)c1cc[nH]c177 chemicals
c1ccc(Cn2ccnn2)cc177 chemicals
c1ccc(Cc2cncs2)cc175 chemicals
c1ccc(Cn2cccc2)cc163 chemicals