Murcko scaffold
Ring system with 2 rings and 10 atoms
97 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 97
- With full pages
- 8
Scaffold SMILES
C1CCN(C2CCC2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 96 of 97 chemicals
trans-2-(4-Ethylpiperidin-1-yl)cyclobutan-1-ol
CAS 2162274-96-4C11H21NO
trans-2-(4-Methoxypiperidin-1-yl)cyclobutan-1-ol
CAS 2150123-93-4C10H19NO2
![tert-Butyl N-{1-[trans-2-hydroxycyclobutyl]piperidin-4-yl}carbamate chemical structure, C14H26N2O3, CAS 2199245-60-6](/s/HKBXLJDYBRIONF-VXGBXAGGSA-N.svg)
tert-Butyl N-{1-[trans-2-hydroxycyclobutyl]piperidin-4-yl}carbamate
CAS 2199245-60-6C14H26N2O3
trans-2-(4-Methylpiperidin-1-yl)cyclobutan-1-ol
CAS 2151000-97-2C10H19NO
![1-[trans-2-Hydroxycyclobutyl]piperidin-4-ol chemical structure, C9H17NO2, CAS 2146167-66-8](/s/YQKSQDLXYUKFEM-RKDXNWHRSA-N.svg)
1-[trans-2-Hydroxycyclobutyl]piperidin-4-ol
CAS 2146167-66-8C9H17NO2
![trans-2-[4-(Dimethylamino)piperidin-1-yl]cyclobutan-1-ol chemical structure, C11H22N2O, CAS 2141539-42-4](/s/QIAXKLIWRCQREI-GHMZBOCLSA-N.svg)
trans-2-[4-(Dimethylamino)piperidin-1-yl]cyclobutan-1-ol
CAS 2141539-42-4C11H22N2O
![1-[trans-2-Hydroxycyclobutyl]piperidine-4-carbonitrile chemical structure, C10H16N2O, CAS 2156556-96-4](/s/FSODSLMKNKJWIU-NXEZZACHSA-N.svg)
1-[trans-2-Hydroxycyclobutyl]piperidine-4-carbonitrile
CAS 2156556-96-4C10H16N2O
trans-2-(Piperidin-1-yl)cyclobutan-1-ol
CAS 2148834-00-6C9H17NO
1-Cyclobutyl-4-piperidinesulfonamide
CAS 2260973-12-2C9H18N2O2S
(1S,2S)-1-Methyl-2-(4-methylpiperidin-1-yl)cyclobutan-1-ol
CAS 2303549-22-4C11H21NO
![2-Chloro-N-[1-(1-cyclobutylpiperidin-3-yl)ethyl]propanamide chemical structure, C14H25ClN2O, CAS 2411287-36-8](/s/PFRWXZQJZOLCKP-UHFFFAOYSA-N.svg)
2-Chloro-N-[1-(1-cyclobutylpiperidin-3-yl)ethyl]propanamide
CAS 2411287-36-8C14H25ClN2O
![2-Chloro-N-[3-[4-(trifluoromethyl)piperidin-1-yl]cyclobutyl]propanamide chemical structure, C13H20ClF3N2O, CAS 2411255-54-2](/s/SLQZYYHDZFESOH-UHFFFAOYSA-N.svg)
2-Chloro-N-[3-[4-(trifluoromethyl)piperidin-1-yl]cyclobutyl]propanamide
CAS 2411255-54-2C13H20ClF3N2O
![N-[1-(1-Cyclobutylpiperidin-3-yl)ethyl]but-2-ynamide chemical structure, C15H24N2O, CAS 2411249-32-4](/s/NYISUEAQEMYMPQ-UHFFFAOYSA-N.svg)
N-[1-(1-Cyclobutylpiperidin-3-yl)ethyl]but-2-ynamide
CAS 2411249-32-4C15H24N2O
![2-Chloro-N-[1-(1-cyclobutylpiperidin-3-yl)ethyl]acetamide chemical structure, C13H23ClN2O, CAS 2411270-77-2](/s/OZQWNUVGDHVQON-UHFFFAOYSA-N.svg)
2-Chloro-N-[1-(1-cyclobutylpiperidin-3-yl)ethyl]acetamide
CAS 2411270-77-2C13H23ClN2O
![(2E)-N-[1-(1-Cyclobutylpiperidin-3-yl)ethyl]-4-(dimethylamino)but-2-enamide chemical structure, C17H31N3O, CAS 2411330-14-6](/s/JALOTOMAJLYXSP-UXBLZVDNSA-N.svg)
(2E)-N-[1-(1-Cyclobutylpiperidin-3-yl)ethyl]-4-(dimethylamino)but-2-enamide
CAS 2411330-14-6C17H31N3O
1-(3,3-Difluorocyclobutyl)-N-methylpiperidin-4-amine
CAS 2002890-36-8C10H18F2N2
![3-[4-(Trifluoromethyl)piperidin-1-yl]cyclobutan-1-amine dihydrochloride chemical structure, C10H19Cl2F3N2, CAS 2639442-17-2](/s/YMNHOGUDWDVQGB-UHFFFAOYSA-N.svg)
3-[4-(Trifluoromethyl)piperidin-1-yl]cyclobutan-1-amine dihydrochloride
CAS 2639442-17-2C10H19Cl2F3N2
(R)-tert-Butyl (1-cyclobutylpiperidin-3-yl)carbamate
CAS 2730880-33-6C14H26N2O2
tert-Butyl (1-(3-ethynylcyclobutyl)piperidin-4-yl)carbamate
CAS 2773490-38-1C16H26N2O2
![3-[3-(3-Methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid chemical structure, C13H19NO2, CAS 2138157-63-6](/s/NOOHSJJXAXLEJF-UHFFFAOYSA-N.svg)
3-[3-(3-Methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid
CAS 2138157-63-6C13H19NO2
![3-[3-(4-Methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid chemical structure, C13H19NO2, CAS 2138157-65-8](/s/SMAYSTMCJRAKFV-UHFFFAOYSA-N.svg)
3-[3-(4-Methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid
CAS 2138157-65-8C13H19NO2
![3-[3-(2-Methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid chemical structure, C13H19NO2, CAS 2138512-95-3](/s/TYKKMOVAZOMOPY-UHFFFAOYSA-N.svg)
3-[3-(2-Methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid
CAS 2138512-95-3C13H19NO2
1-(2-Hydroxycyclobutyl)piperidine-3-carboxylic acid
CAS 2138223-74-0C10H17NO3
![3-[3-(2,3-Dimethylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid chemical structure, C14H21NO2, CAS 2137936-41-3](/s/OALRIRUVZQKGEB-UHFFFAOYSA-N.svg)
3-[3-(2,3-Dimethylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid
CAS 2137936-41-3C14H21NO2
- 2-(2,6-Dimethylpiperidin-1-yl)cyclobutan-1-ol2137562-13-9C11H21NO
- 1-(2-Hydroxycyclobutyl)piperidine-4-carboxylic acid2138004-53-0C10H17NO3
- 3-[3-(2,6-Dimethylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid2137604-15-8C14H21NO2
- 3-[3-(3,5-Dimethylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid2137604-20-5C14H21NO2
- 3-{3-[3-(Dimethylamino)piperidin-1-yl]cyclobutyl}prop-2-ynoic acid2138276-46-5C14H22N2O2
- 3-[3-(Dimethylamino)piperidin-1-yl]cyclobutane-1-carboxylic acid2138072-40-7C12H22N2O2
- 3-(4-Ethyl-4-methylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138112-21-5C13H23NO2
- 3-(3-Methylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138050-35-6C11H19NO2
- 3-(3,5-Dimethylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138060-83-8C12H21NO2
- 3-(2-Methylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138566-16-0C11H19NO2
- 3-(2,3-Dimethylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138576-75-5C12H21NO2
- 3-[3-(Piperidin-1-yl)cyclobutyl]prop-2-ynoic acid2137567-86-1C12H17NO2
- 3-[3-(4-Ethyl-4-methylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid2137579-53-2C15H23NO2
- 3-(2,2,6,6-Tetramethylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138081-28-2C14H25NO2
- 1-Cyclobutyl-2,6-dimethylpiperidine-4-carbaldehyde2137610-98-9C12H21NO
- 3-(2,6-Dimethylpiperidin-1-yl)cyclobutane-1-carboxylic acid2138575-65-0C12H21NO2
- 3-[3-(4,4-Dimethylpiperidin-1-yl)cyclobutyl]prop-2-ynoic acid2138389-58-7C14H21NO2
- 1-(3,3-Difluorocyclobutyl)-N-methylpiperidin-4-amine hydrochloride2759342-83-9C10H19ClF2N2
- 1-(2-Fluorocyclobutyl)piperidine-4-carbonitrile2749293-65-8C10H15FN2
- 2-(1-(2-Fluorocyclobutyl)piperidin-4-yl)acetonitrile2753170-44-2C11H17FN2
- tert-Butyl (1-(2-fluorocyclobutyl)piperidin-4-yl)carbamate2749758-48-1C14H25FN2O2
- (R)-1-Cyclobutylpiperidin-3-amine hydrochloride2893971-00-9C9H19ClN2
- 1-Cyclobutylpiperidin-3-amine Hydrochloride2840708-44-1C9H19ClN2
- 1-(1-Cyclobutyl-4-fluoropiperidin-4-yl)methanamine dihydrochloride3049388-95-3C10H21Cl2FN2
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Same ring framework with different atoms or bond orders
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