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Murcko scaffold

5,6,7,8-Tetrahydro-1-phenylisoquinoline scaffold

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
13
With full pages
3
Scaffold SMILES

c1ccc(-c2nccc3c2CCCC3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5,6,7,8-Tetrahydro-1-phenylisoquinoline page
Murcko scaffold c1ccc(-c2nccc3c2CCCC3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-[(4-Cyano-1-phenyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]acetamide chemical structure, C18H17N3OS, CAS 315246-76-5
2-[(4-Cyano-1-phenyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]acetamide
CAS 315246-76-5C18H17N3OS
Methyl 2-{[4-cyano-1-(4-methylphenyl)-5,6,7,8-tetrahydro-3-isoquinolinyl]sulfanyl}acetate chemical structure, C20H20N2O2S, CAS 861209-23-6
Methyl 2-{[4-cyano-1-(4-methylphenyl)-5,6,7,8-tetrahydro-3-isoquinolinyl]sulfanyl}acetate
CAS 861209-23-6C20H20N2O2S
3-(Methylsulfanyl)-1-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C18H15F3N2S, CAS 607697-02-9
3-(Methylsulfanyl)-1-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 607697-02-9C18H15F3N2S
3-[(2-Methylpropyl)sulfanyl]-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C20H22N2S, CAS 315246-93-6
3-[(2-Methylpropyl)sulfanyl]-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 315246-93-6C20H22N2S
1-(4-Chlorophenyl)-3-[(3-fluoropropyl)sulfanyl]-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C19H18ClFN2S, CAS 691868-87-8
1-(4-Chlorophenyl)-3-[(3-fluoropropyl)sulfanyl]-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 691868-87-8C19H18ClFN2S
1-(4-Methylphenyl)-3-[(3,4,4-trifluoro-3-butenyl)sulfanyl]-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C21H19F3N2S, CAS 691868-96-9
1-(4-Methylphenyl)-3-[(3,4,4-trifluoro-3-butenyl)sulfanyl]-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 691868-96-9C21H19F3N2S
3-[(Cyanomethyl)sulfanyl]-1-(3-methylphenyl)-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C19H17N3S, CAS 439107-38-7
3-[(Cyanomethyl)sulfanyl]-1-(3-methylphenyl)-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 439107-38-7C19H17N3S
Methyl 2-{[4-cyano-1-(3-methylphenyl)-5,6,7,8-tetrahydro-3-isoquinolinyl]sulfanyl}acetate chemical structure, C20H20N2O2S, CAS 439107-44-5
Methyl 2-{[4-cyano-1-(3-methylphenyl)-5,6,7,8-tetrahydro-3-isoquinolinyl]sulfanyl}acetate
CAS 439107-44-5C20H20N2O2S
3-[(Cyanomethyl)sulfanyl]-1-(4-methylphenyl)-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C19H17N3S, CAS 439096-33-0
3-[(Cyanomethyl)sulfanyl]-1-(4-methylphenyl)-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 439096-33-0C19H17N3S
3-Chloro-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C16H13ClN2, CAS 53661-35-1
3-Chloro-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 53661-35-1C16H13ClN2
3-[(Cyanomethyl)sulfanyl]-1-phenyl-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C18H15N3S, CAS 315246-86-7
3-[(Cyanomethyl)sulfanyl]-1-phenyl-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 315246-86-7C18H15N3S
Methyl 2-[(4-cyano-1-phenyl-5,6,7,8-tetrahydro-3-isoquinolinyl)sulfanyl]acetate chemical structure, C19H18N2O2S, CAS 861212-86-4
Methyl 2-[(4-cyano-1-phenyl-5,6,7,8-tetrahydro-3-isoquinolinyl)sulfanyl]acetate
CAS 861212-86-4C19H18N2O2S
5,6,7,8-Tetrahydro-1-phenylisoquinoline chemical structure, C15H15N, CAS 881036-99-3
5,6,7,8-Tetrahydro-1-phenylisoquinoline
CAS 881036-99-3C15H15N