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Murcko scaffold

Ring system with 4 rings and 21 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
9
With full pages
0
Scaffold SMILES

c1ccc(N2CCN(c3ccnc4ncnn34)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCN(c3ccnc4ncnn34)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

7-[4-(4-Fluorophenyl)piperazin-1-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine chemical structure, C16H17FN6, CAS 898665-39-9
7-[4-(4-Fluorophenyl)piperazin-1-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
CAS 898665-39-9C16H17FN6
6-Chloro-7-[4-(2-methoxyphenyl)piperazin-1-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine chemical structure, C17H19ClN6O, CAS 879056-62-9
6-Chloro-7-[4-(2-methoxyphenyl)piperazin-1-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
CAS 879056-62-9C17H19ClN6O
1-(2-Chlorophenyl)-4-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazine chemical structure, C16H17ClN6, CAS 1062268-94-3
1-(2-Chlorophenyl)-4-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazine
CAS 1062268-94-3C16H17ClN6
7-[4-(2,5-Dimethylphenyl)piperazin-1-yl]-5,6-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine chemical structure, C19H24N6, CAS 951536-07-5
7-[4-(2,5-Dimethylphenyl)piperazin-1-yl]-5,6-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine
CAS 951536-07-5C19H24N6
1-(5-Chloro-2-methylphenyl)-4-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazine chemical structure, C17H19ClN6, CAS 898740-67-5
1-(5-Chloro-2-methylphenyl)-4-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazine
CAS 898740-67-5C17H19ClN6
4-(4-{5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazin-1-yl)-3-(trifluoromethyl)benzene-1-sulfonamide chemical structure, C17H18F3N7O2S, CAS 3054588-61-0
4-(4-{5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazin-1-yl)-3-(trifluoromethyl)benzene-1-sulfonamide
CAS 3054588-61-0C17H18F3N7O2S
1-{5,6-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}-4-(2-methylphenyl)piperazine chemical structure, C18H22N6, CAS 2640885-70-5
1-{5,6-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}-4-(2-methylphenyl)piperazine
CAS 2640885-70-5C18H22N6
1-(3-Bromophenyl)-4-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazine chemical structure, C16H17BrN6, CAS 2770643-99-5
1-(3-Bromophenyl)-4-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazine
CAS 2770643-99-5C16H17BrN6
4-(4-{5,6-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazin-1-yl)-3-(trifluoromethyl)benzene-1-sulfonamide chemical structure, C18H20F3N7O2S, CAS 3054429-18-1
4-(4-{5,6-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazin-1-yl)-3-(trifluoromethyl)benzene-1-sulfonamide
CAS 3054429-18-1C18H20F3N7O2S