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Murcko scaffold

Ring system with 2 rings and 13 atoms

31 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
31
With full pages
6
Scaffold SMILES

O=c1ccn(C2CSCO2)c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccn(C2CSCO2)c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

1-((2R,5S)-2-(Hydroxymethyl-1,3-oxathiolan-5-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione chemical structure, C8H9FN2O4S, CAS 145986-11-4
1-((2R,5S)-2-(Hydroxymethyl-1,3-oxathiolan-5-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
CAS 145986-11-4C8H9FN2O4S
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-methyl-, (2S-cis)- chemical structure, C9H12N2O4S, CAS 137623-42-8
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-methyl-, (2S-cis)-
CAS 137623-42-8C9H12N2O4S
1-[(2S,5R)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione chemical structure, C8H10N2O4S, CAS 149819-44-3
1-[(2S,5R)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione
CAS 149819-44-3C8H10N2O4S
1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidine-2,4(1H,3H)-dione, (2R,5S)- chemical structure, C8H10N2O4S, CAS 145986-07-8
1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidine-2,4(1H,3H)-dione, (2R,5S)-
CAS 145986-07-8C8H10N2O4S
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)- chemical structure, C8H10N2O4S, CAS 145986-08-9
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)-
CAS 145986-08-9C8H10N2O4S
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-methyl-, (2R-cis)- chemical structure, C9H12N2O4S, CAS 145986-09-0
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-methyl-, (2R-cis)-
CAS 145986-09-0C9H12N2O4S
alpha-L-(+)-(2R,5R)-1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)thymine chemical structure, C9H12N2O4S, CAS 145986-10-3
alpha-L-(+)-(2R,5R)-1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)thymine
CAS 145986-10-3C9H12N2O4S
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)- chemical structure, C8H9FN2O4S, CAS 145986-12-5
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)-
CAS 145986-12-5C8H9FN2O4S
2,4(1H,3H)-Pyrimidinedione, 5-chloro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)- chemical structure, C8H9ClN2O4S, CAS 145986-13-6
2,4(1H,3H)-Pyrimidinedione, 5-chloro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-
CAS 145986-13-6C8H9ClN2O4S
2,4(1H,3H)-Pyrimidinedione, 5-chloro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)- chemical structure, C8H9ClN2O4S, CAS 145986-14-7
2,4(1H,3H)-Pyrimidinedione, 5-chloro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)-
CAS 145986-14-7C8H9ClN2O4S
2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)- chemical structure, C8H9BrN2O4S, CAS 145986-15-8
2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-
CAS 145986-15-8C8H9BrN2O4S
2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)- chemical structure, C8H9BrN2O4S, CAS 145986-16-9
2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-trans)-
CAS 145986-16-9C8H9BrN2O4S
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-iodo-, (2R-cis)- chemical structure, C8H9IN2O4S, CAS 145986-17-0
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-iodo-, (2R-cis)-
CAS 145986-17-0C8H9IN2O4S
Oxathiolan 5IU-alpha chemical structure, C8H9IN2O4S, CAS 145986-18-1
Oxathiolan 5IU-alpha
CAS 145986-18-1C8H9IN2O4S
2',3'-Dideoxy-5-fluoro-3'-thiauridine chemical structure, C8H9FN2O4S, CAS 143790-05-0
2',3'-Dideoxy-5-fluoro-3'-thiauridine
CAS 143790-05-0C8H9FN2O4S
2,4(1H,3H)-Pyrimidinedione, 5-chloro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-cis)- chemical structure, C8H9ClN2O4S, CAS 137530-46-2
2,4(1H,3H)-Pyrimidinedione, 5-chloro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-cis)-
CAS 137530-46-2C8H9ClN2O4S
2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-cis)- chemical structure, C8H9BrN2O4S, CAS 137530-47-3
2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-cis)-
CAS 137530-47-3C8H9BrN2O4S
(+)-(2S,5R)-5-Iodo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)uracil chemical structure, C8H9IN2O4S, CAS 137530-48-4
(+)-(2S,5R)-5-Iodo-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)uracil
CAS 137530-48-4C8H9IN2O4S
OxathiolanU-(-)-alpha chemical structure, C8H10N2O4S, CAS 149819-45-4
OxathiolanU-(-)-alpha
CAS 149819-45-4C8H10N2O4S
OxathiolanT-(-)-alpha chemical structure, C9H12N2O4S, CAS 149819-46-5
OxathiolanT-(-)-alpha
CAS 149819-46-5C9H12N2O4S
1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione chemical structure, C8H10N2O4S, CAS 131086-26-5
1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione
CAS 131086-26-5C8H10N2O4S
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-iodo-, (2S-trans)- chemical structure, C8H9IN2O4S, CAS 149819-50-1
2,4(1H,3H)-Pyrimidinedione, 1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-iodo-, (2S-trans)-
CAS 149819-50-1C8H9IN2O4S
Oxathiolan, 5FU-(-)-alpha chemical structure, C8H9FN2O4S, CAS 149819-47-6
Oxathiolan, 5FU-(-)-alpha
CAS 149819-47-6C8H9FN2O4S
Oxathiolan, 5ClU-(-)-alpha chemical structure, C8H9ClN2O4S, CAS 149819-48-7
Oxathiolan, 5ClU-(-)-alpha
CAS 149819-48-7C8H9ClN2O4S