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Murcko scaffold

N-Phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline scaffold

45 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
45
With full pages
23
Scaffold SMILES

O=C(Nc1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline page
Murcko scaffold O=C(Nc1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 45 of 45 chemicals

N-(3-Chlorophenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C16H15ClN2O, CAS 362473-70-9
N-(3-Chlorophenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 362473-70-9C16H15ClN2O
N-(3,4-Dichlorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide chemical structure, C16H14Cl2N2O, CAS 333768-51-7
N-(3,4-Dichlorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
CAS 333768-51-7C16H14Cl2N2O
N-(2-Methoxyphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C17H18N2O2, CAS 406929-87-1
N-(2-Methoxyphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 406929-87-1C17H18N2O2
N-Phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C16H16N2O, CAS 83491-16-1
N-Phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline
CAS 83491-16-1C16H16N2O
N-(4-Chlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide chemical structure, C16H15ClN2O, CAS 333444-56-7
N-(4-Chlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
CAS 333444-56-7C16H15ClN2O
N-(3,4-Dimethoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide chemical structure, C18H20N2O3, CAS 701932-45-8
N-(3,4-Dimethoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
CAS 701932-45-8C18H20N2O3
Ethyl 4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)amino]benzoate chemical structure, C19H20N2O3, CAS 701945-99-5
Ethyl 4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)amino]benzoate
CAS 701945-99-5C19H20N2O3
N-(3-Acetylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C18H18N2O2, CAS 708224-19-5
N-(3-Acetylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 708224-19-5C18H18N2O2
N-(4-Acetylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C18H18N2O2, CAS 692732-82-4
N-(4-Acetylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 692732-82-4C18H18N2O2
N-(4-Methylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C17H18N2O, CAS 304659-09-4
N-(4-Methylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 304659-09-4C17H18N2O
1-(Cyanomethyl)-N-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C19H16F3N3O, CAS 339011-95-9
1-(Cyanomethyl)-N-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 339011-95-9C19H16F3N3O
1-(Cyanomethyl)-N-(2,4-dichlorophenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C18H15Cl2N3O, CAS 339011-96-0
1-(Cyanomethyl)-N-(2,4-dichlorophenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 339011-96-0C18H15Cl2N3O
1-(Cyanomethyl)-N-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C19H16F3N3O, CAS 339011-97-1
1-(Cyanomethyl)-N-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 339011-97-1C19H16F3N3O
N-(3,5-Dimethoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide chemical structure, C18H20N2O3, CAS 925626-78-4
N-(3,5-Dimethoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
CAS 925626-78-4C18H20N2O3
N~3~-(tert-butyl)-N~2~-(4-chlorophenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide chemical structure, C21H24ClN3O2, CAS 318256-30-3
N~3~-(tert-butyl)-N~2~-(4-chlorophenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide
CAS 318256-30-3C21H24ClN3O2
N-(3-Chlorophenyl)-1-(cyanomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C18H16ClN3O, CAS 338761-88-9
N-(3-Chlorophenyl)-1-(cyanomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 338761-88-9C18H16ClN3O
N~3~-(tert-butyl)-N~2~-[3-(trifluoromethyl)phenyl]-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide chemical structure, C22H24F3N3O2, CAS 318517-12-3
N~3~-(tert-butyl)-N~2~-[3-(trifluoromethyl)phenyl]-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide
CAS 318517-12-3C22H24F3N3O2
N~3~-(tert-butyl)-N~2~-(4-methylphenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide chemical structure, C22H27N3O2, CAS 318517-14-5
N~3~-(tert-butyl)-N~2~-(4-methylphenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide
CAS 318517-14-5C22H27N3O2
N~3~-(tert-butyl)-N~2~-(3-chlorophenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide chemical structure, C21H24ClN3O2, CAS 318517-16-7
N~3~-(tert-butyl)-N~2~-(3-chlorophenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide
CAS 318517-16-7C21H24ClN3O2
N~3~-(tert-butyl)-N~2~-(2-chlorophenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide chemical structure, C21H24ClN3O2, CAS 318517-20-3
N~3~-(tert-butyl)-N~2~-(2-chlorophenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide
CAS 318517-20-3C21H24ClN3O2
N~3~-(tert-butyl)-N~2~-(4-methoxyphenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide chemical structure, C22H27N3O3, CAS 318256-28-9
N~3~-(tert-butyl)-N~2~-(4-methoxyphenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide
CAS 318256-28-9C22H27N3O3
N-(4-Chloro-3-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide chemical structure, C17H14ClF3N2O, CAS 1022641-41-3
N-(4-Chloro-3-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
CAS 1022641-41-3C17H14ClF3N2O
N-(4-Ethoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide chemical structure, C18H20N2O2, CAS 899020-19-0
N-(4-Ethoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
CAS 899020-19-0C18H20N2O2
N-(4-Chlorophenyl)-1-(cyanomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide chemical structure, C18H16ClN3O, CAS 338953-57-4
N-(4-Chlorophenyl)-1-(cyanomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
CAS 338953-57-4C18H16ClN3O