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Murcko scaffold

Ring system with 3 rings and 20 atoms

217 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
217
With full pages
61
Scaffold SMILES

O=C(Nc1ccccc1)c1cc2ccccc2[nH]c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cc2ccccc2[nH]c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 217 chemicals

3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-N-phenyl- chemical structure, C17H14N2O2, CAS 667897-40-7
3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-N-phenyl-
CAS 667897-40-7C17H14N2O2
N-(4-Bromophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C16H11BrN2O2, CAS 62033-67-4
N-(4-Bromophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 62033-67-4C16H11BrN2O2
N-(2,5-Dimethylphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C18H16N2O2, CAS 62033-68-5
N-(2,5-Dimethylphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 62033-68-5C18H16N2O2
N-(3-Methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C17H14N2O3, CAS 62033-69-6
N-(3-Methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 62033-69-6C17H14N2O3
N-(4-Methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C17H14N2O3, CAS 62033-70-9
N-(4-Methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 62033-70-9C17H14N2O3
N-(4-Iodophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C16H11IN2O2, CAS 62033-66-3
N-(4-Iodophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 62033-66-3C16H11IN2O2
Laquinimod sodium chemical structure, C19H16ClN2NaO3, CAS 248282-07-7
Laquinimod sodium
CAS 248282-07-7C19H16ClN2NaO3
N,1-Dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C18H16N2O2, CAS 551936-81-3
N,1-Dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
CAS 551936-81-3C18H16N2O2
1,2-Dihydro-4-hydroxy-5-methoxy-N-(4-methoxyphenyl)-N,1-dimethyl-2-oxo-3-quinolinecarboxamide chemical structure, C20H20N2O5, CAS 675575-46-9
1,2-Dihydro-4-hydroxy-5-methoxy-N-(4-methoxyphenyl)-N,1-dimethyl-2-oxo-3-quinolinecarboxamide
CAS 675575-46-9C20H20N2O5
N-(2-Aminophenyl)-1-ethyl-4-hydroxy-2-oxoquinoline-3-carboxamide chemical structure, C18H17N3O3, CAS 151449-79-5
N-(2-Aminophenyl)-1-ethyl-4-hydroxy-2-oxoquinoline-3-carboxamide
CAS 151449-79-5C18H17N3O3
4-Hydroxy-N-(4-methoxyphenyl)-2-oxo-1-pentyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C22H24N2O4, CAS 331260-24-3
4-Hydroxy-N-(4-methoxyphenyl)-2-oxo-1-pentyl-1,2-dihydroquinoline-3-carboxamide
CAS 331260-24-3C22H24N2O4
1-Ethyl-4-hydroxy-N-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H18N2O4, CAS 303093-35-8
1-Ethyl-4-hydroxy-N-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 303093-35-8C19H18N2O4
N-(5-Chloro-2-methoxyphenyl)-4-hydroxy-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C20H19ClN2O4, CAS 304881-20-7
N-(5-Chloro-2-methoxyphenyl)-4-hydroxy-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide
CAS 304881-20-7C20H19ClN2O4
N-(2-Bromophenyl)-4-hydroxy-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H17BrN2O3, CAS 372090-26-1
N-(2-Bromophenyl)-4-hydroxy-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide
CAS 372090-26-1C19H17BrN2O3
1-Allyl-4-hydroxy-2-oxo-N-phenyl-1,2-dihydro-3-quinolinecarboxamide chemical structure, C19H16N2O3, CAS 84088-47-1
1-Allyl-4-hydroxy-2-oxo-N-phenyl-1,2-dihydro-3-quinolinecarboxamide
CAS 84088-47-1C19H16N2O3
4-Hydroxy-1-(3-methylbutyl)-N-(4-methylphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C22H24N2O3, CAS 4506-70-1
4-Hydroxy-1-(3-methylbutyl)-N-(4-methylphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 4506-70-1C22H24N2O3
4-Hydroxy-N-{4-nitrophenyl}-2-oxo-1-prop-2-enyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H15N3O5, CAS 331653-23-7
4-Hydroxy-N-{4-nitrophenyl}-2-oxo-1-prop-2-enyl-1,2-dihydroquinoline-3-carboxamide
CAS 331653-23-7C19H15N3O5
1-Butyl-N-(5-chloro-2-methoxyphenyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C21H21ClN2O4, CAS 317840-38-3
1-Butyl-N-(5-chloro-2-methoxyphenyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 317840-38-3C21H21ClN2O4
4-Hydroxy-N-(4-hydroxyphenyl)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H18N2O4, CAS 300716-37-4
4-Hydroxy-N-(4-hydroxyphenyl)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide
CAS 300716-37-4C19H18N2O4
1-Ethyl-4-hydroxy-N-{4-nitrophenyl}-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C18H15N3O5, CAS 331653-22-6
1-Ethyl-4-hydroxy-N-{4-nitrophenyl}-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 331653-22-6C18H15N3O5
1-Butyl-4-hydroxy-N-(2-hydroxy-5-nitrophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C20H19N3O6, CAS 400753-62-0
1-Butyl-4-hydroxy-N-(2-hydroxy-5-nitrophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 400753-62-0C20H19N3O6
N-(2-Fluorophenyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C17H13FN2O3, CAS 313980-63-1
N-(2-Fluorophenyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 313980-63-1C17H13FN2O3
1-Ethyl-4-hydroxy-N-(2-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H18N2O4, CAS 301355-22-6
1-Ethyl-4-hydroxy-N-(2-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 301355-22-6C19H18N2O4
4-Hydroxy-N-(3-methoxyphenyl)-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C18H16N2O4, CAS 303093-34-7
4-Hydroxy-N-(3-methoxyphenyl)-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 303093-34-7C18H16N2O4