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Murcko scaffold

Ring system with 2 rings and 19 atoms

33 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
19
Chemicals
33
With full pages
9
Scaffold SMILES

O=C(CNC(=O)c1cccnc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNC(=O)c1cccnc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-(4-methylphenyl)acetamide chemical structure, C16H16ClN3O2, CAS 745803-27-4
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-(4-methylphenyl)acetamide
CAS 745803-27-4C16H16ClN3O2
N-(2-((4-Chlorophenyl)amino)-2-oxoethyl)-N-methyl-2-(methylthio)nicotinamide chemical structure, C16H16ClN3O2S, CAS 796066-96-1
N-(2-((4-Chlorophenyl)amino)-2-oxoethyl)-N-methyl-2-(methylthio)nicotinamide
CAS 796066-96-1C16H16ClN3O2S
2-[1-(5,6-Dichloropyridin-3-yl)-N-ethylformamido]-N-(3-methoxyphenyl)acetamide chemical structure, C17H17Cl2N3O3, CAS 854025-52-8
2-[1-(5,6-Dichloropyridin-3-yl)-N-ethylformamido]-N-(3-methoxyphenyl)acetamide
CAS 854025-52-8C17H17Cl2N3O3
2-[1-(5,6-Dichloropyridin-3-yl)-N-methylformamido]-N-(4-methoxyphenyl)acetamide chemical structure, C16H15Cl2N3O3, CAS 847759-13-1
2-[1-(5,6-Dichloropyridin-3-yl)-N-methylformamido]-N-(4-methoxyphenyl)acetamide
CAS 847759-13-1C16H15Cl2N3O3
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-(2,5-dimethylphenyl)acetamide chemical structure, C17H18ClN3O2, CAS 848370-39-8
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-(2,5-dimethylphenyl)acetamide
CAS 848370-39-8C17H18ClN3O2
2-[1-(5,6-Dichloropyridin-3-yl)-N-methylformamido]-N-[2-(methylsulfanyl)phenyl]acetamide chemical structure, C16H15Cl2N3O2S, CAS 854033-60-6
2-[1-(5,6-Dichloropyridin-3-yl)-N-methylformamido]-N-[2-(methylsulfanyl)phenyl]acetamide
CAS 854033-60-6C16H15Cl2N3O2S
2-{[2-(Methylsulfanyl)pyridin-3-yl]formamido}-N-(2,3,4-trifluorophenyl)acetamide chemical structure, C15H12F3N3O2S, CAS 880282-45-1
2-{[2-(Methylsulfanyl)pyridin-3-yl]formamido}-N-(2,3,4-trifluorophenyl)acetamide
CAS 880282-45-1C15H12F3N3O2S
2-[1-(5,6-Dichloropyridin-3-yl)-N-methylformamido]-N-(3-methoxyphenyl)acetamide chemical structure, C16H15Cl2N3O3, CAS 906266-98-6
2-[1-(5,6-Dichloropyridin-3-yl)-N-methylformamido]-N-(3-methoxyphenyl)acetamide
CAS 906266-98-6C16H15Cl2N3O3
2-[1-(5,6-Dichloropyridin-3-yl)-N-propylformamido]-N-(2-methoxyphenyl)acetamide chemical structure, C18H19Cl2N3O3, CAS 877937-50-3
2-[1-(5,6-Dichloropyridin-3-yl)-N-propylformamido]-N-(2-methoxyphenyl)acetamide
CAS 877937-50-3C18H19Cl2N3O3
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-[4-(trifluoromethoxy)phenyl]acetamide chemical structure, C16H13ClF3N3O3, CAS 1110885-57-8
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-[4-(trifluoromethoxy)phenyl]acetamide
CAS 1110885-57-8C16H13ClF3N3O3
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-(4-fluorophenyl)acetamide chemical structure, C15H13ClFN3O2, CAS 1110894-05-7
2-[1-(6-Chloropyridin-3-yl)-N-methylformamido]-N-(4-fluorophenyl)acetamide
CAS 1110894-05-7C15H13ClFN3O2
N-[2-(4-Bromo-2-methylanilino)-2-oxoethyl]-6-chloro-N-methylpyridine-3-carboxamide chemical structure, C16H15BrClN3O2, CAS 1203154-62-4
N-[2-(4-Bromo-2-methylanilino)-2-oxoethyl]-6-chloro-N-methylpyridine-3-carboxamide
CAS 1203154-62-4C16H15BrClN3O2
N-[2-[4-Chloro-3-(trifluoromethyl)anilino]-2-oxoethyl]-N-methyl-2-methylsulfanylpyridine-3-carboxamide chemical structure, C17H15ClF3N3O2S, CAS 926399-78-2
N-[2-[4-Chloro-3-(trifluoromethyl)anilino]-2-oxoethyl]-N-methyl-2-methylsulfanylpyridine-3-carboxamide
CAS 926399-78-2C17H15ClF3N3O2S
N-(2,3-Dimethylphenyl)-2-[N-(2-methoxyethyl)-1-[2-(methylsulfanyl)pyridin-3-yl]formamido]acetamide chemical structure, C20H25N3O3S, CAS 931642-20-5
N-(2,3-Dimethylphenyl)-2-[N-(2-methoxyethyl)-1-[2-(methylsulfanyl)pyridin-3-yl]formamido]acetamide
CAS 931642-20-5C20H25N3O3S
2-{N-Methyl-1-[2-(methylsulfanyl)pyridin-3-yl]formamido}-N-(2,3,4-trifluorophenyl)acetamide chemical structure, C16H14F3N3O2S, CAS 949210-14-4
2-{N-Methyl-1-[2-(methylsulfanyl)pyridin-3-yl]formamido}-N-(2,3,4-trifluorophenyl)acetamide
CAS 949210-14-4C16H14F3N3O2S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[1-(5,6-dichloropyridin-3-yl)-N-methylformamido]acetamide chemical structure, C16H11Cl3F3N3O2, CAS 924207-96-5
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[1-(5,6-dichloropyridin-3-yl)-N-methylformamido]acetamide
CAS 924207-96-5C16H11Cl3F3N3O2
N-(4-Bromo-2-methylphenyl)-2-[1-(5,6-dichloropyridin-3-yl)-N-methylformamido]acetamide chemical structure, C16H14BrCl2N3O2, CAS 930542-99-7
N-(4-Bromo-2-methylphenyl)-2-[1-(5,6-dichloropyridin-3-yl)-N-methylformamido]acetamide
CAS 930542-99-7C16H14BrCl2N3O2
N-(3,4-Difluorophenyl)-2-{[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide chemical structure, C15H13F2N3O2S, CAS 1007771-50-7
N-(3,4-Difluorophenyl)-2-{[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide
CAS 1007771-50-7C15H13F2N3O2S
N-[2-(3-Fluoroanilino)-2-keto-ethyl]-N-methyl-2-(methylthio)nicotinamide chemical structure, C16H16FN3O2S, CAS 1017095-29-2
N-[2-(3-Fluoroanilino)-2-keto-ethyl]-N-methyl-2-(methylthio)nicotinamide
CAS 1017095-29-2C16H16FN3O2S
N-(3,4-Diethoxyphenyl)-2-{N-methyl-1-[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide chemical structure, C20H25N3O4S, CAS 1011450-86-4
N-(3,4-Diethoxyphenyl)-2-{N-methyl-1-[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide
CAS 1011450-86-4C20H25N3O4S
N-(2,6-Difluorophenyl)-2-{N-ethyl-1-[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide chemical structure, C17H17F2N3O2S, CAS 1016354-87-2
N-(2,6-Difluorophenyl)-2-{N-ethyl-1-[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide
CAS 1016354-87-2C17H17F2N3O2S
2-[1-(6-Chloropyridin-3-yl)-N-ethylformamido]-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C17H15ClF3N3O2, CAS 1286864-24-1
2-[1-(6-Chloropyridin-3-yl)-N-ethylformamido]-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 1286864-24-1C17H15ClF3N3O2
N-(2-Bromophenyl)-2-{[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide chemical structure, C15H14BrN3O2S, CAS 1111544-00-3
N-(2-Bromophenyl)-2-{[2-(methylsulfanyl)pyridin-3-yl]formamido}acetamide
CAS 1111544-00-3C15H14BrN3O2S
2-[(6-Chloropyridin-3-yl)formamido]-N-(2,3,4-trifluorophenyl)acetamide chemical structure, C14H9ClF3N3O2, CAS 1203386-29-1
2-[(6-Chloropyridin-3-yl)formamido]-N-(2,3,4-trifluorophenyl)acetamide
CAS 1203386-29-1C14H9ClF3N3O2