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Murcko scaffold

Ring system with 4 rings and 18 atoms

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
18
Chemicals
32
With full pages
3
Scaffold SMILES

c1ccc2sc(-c3csc4c3CCNC4)nc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc2sc(-c3csc4c3CCNC4)nc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

Ethyl 2-acetamido-3-(benzo[d]thiazol-2-yl)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C19H19N3O3S2, CAS 946309-42-8
Ethyl 2-acetamido-3-(benzo[d]thiazol-2-yl)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 946309-42-8C19H19N3O3S2
N-(3-(Benzo[d]thiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide hydrochloride chemical structure, C18H19N3OS2, CAS 524708-00-7
N-(3-(Benzo[d]thiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide hydrochloride
CAS 524708-00-7C18H19N3OS2
APE1 Inhibitor III chemical structure, C19H21N3OS2, CAS 524708-03-0
APE1 Inhibitor III
CAS 524708-03-0C19H21N3OS2
Ethyl 3-(benzo[d]thiazol-2-yl)-2-pentanamido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C22H25N3O3S2, CAS 946276-67-1
Ethyl 3-(benzo[d]thiazol-2-yl)-2-pentanamido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 946276-67-1C22H25N3O3S2
Ethyl 3-(benzo[d]thiazol-2-yl)-2-butyramido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C21H23N3O3S2, CAS 946309-54-2
Ethyl 3-(benzo[d]thiazol-2-yl)-2-butyramido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 946309-54-2C21H23N3O3S2
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)pivalamide chemical structure, C21H23N3O2S2, CAS 864859-75-6
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)pivalamide
CAS 864859-75-6C21H23N3O2S2
Ethyl 3-(1,3-benzothiazol-2-yl)-2-(propanoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-6-carboxylate chemical structure, C20H21N3O3S2, CAS 887889-29-4
Ethyl 3-(1,3-benzothiazol-2-yl)-2-(propanoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-6-carboxylate
CAS 887889-29-4C20H21N3O3S2
Ethyl 3-(benzo[d]thiazol-2-yl)-2-isobutyramido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C21H23N3O3S2, CAS 887222-86-8
Ethyl 3-(benzo[d]thiazol-2-yl)-2-isobutyramido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 887222-86-8C21H23N3O3S2
N-[6-Acetyl-3-(1,3-benzothiazol-2-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide chemical structure, C18H17N3O2S2, CAS 864859-30-3
N-[6-Acetyl-3-(1,3-benzothiazol-2-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide
CAS 864859-30-3C18H17N3O2S2
Ethyl 3-(benzo[d]thiazol-2-yl)-2-pivalamido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C22H25N3O3S2, CAS 946236-64-2
Ethyl 3-(benzo[d]thiazol-2-yl)-2-pivalamido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 946236-64-2C22H25N3O3S2
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)propionamide chemical structure, C19H19N3O2S2, CAS 864859-72-3
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)propionamide
CAS 864859-72-3C19H19N3O2S2
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)butyramide chemical structure, C20H21N3O2S2, CAS 864859-82-5
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)butyramide
CAS 864859-82-5C20H21N3O2S2
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)isobutyramide chemical structure, C20H21N3O2S2, CAS 864859-73-4
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)isobutyramide
CAS 864859-73-4C20H21N3O2S2
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)pentanamide chemical structure, C21H23N3O2S2, CAS 864859-74-5
N-(6-Acetyl-3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)pentanamide
CAS 864859-74-5C21H23N3O2S2
Methyl 3-(benzo[d]thiazol-2-yl)-2-isobutyramido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C20H21N3O3S2, CAS 886951-87-7
Methyl 3-(benzo[d]thiazol-2-yl)-2-isobutyramido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 886951-87-7C20H21N3O3S2
1-(2-Amino-3-(benzo[d]thiazol-2-yl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl)ethan-1-one chemical structure, C16H15N3OS2, CAS 1105194-28-2
1-(2-Amino-3-(benzo[d]thiazol-2-yl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl)ethan-1-one
CAS 1105194-28-2C16H15N3OS2
Ethyl 2-amino-3-(1,3-benzothiazol-2-yl)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate chemical structure, C17H17N3O2S2, CAS 1105194-36-2
Ethyl 2-amino-3-(1,3-benzothiazol-2-yl)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate
CAS 1105194-36-2C17H17N3O2S2
3-(1,3-Benzothiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-amine chemical structure, C16H17N3S2, CAS 1105194-85-1
3-(1,3-Benzothiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-amine
CAS 1105194-85-1C16H17N3S2
3-(1,3-Benzothiazol-2-yl)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-amine chemical structure, C15H15N3S2, CAS 1006596-05-9
3-(1,3-Benzothiazol-2-yl)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-amine
CAS 1006596-05-9C15H15N3S2
N-(3-(Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)propionamide hydrochloride chemical structure, C20H24ClN3OS2, CAS 1189493-87-5
N-(3-(Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)propionamide hydrochloride
CAS 1189493-87-5C20H24ClN3OS2
N-(3-(Benzo[d]thiazol-2-yl)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)isobutyramide hydrochloride chemical structure, C19H22ClN3OS2, CAS 1185066-18-5
N-(3-(Benzo[d]thiazol-2-yl)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)isobutyramide hydrochloride
CAS 1185066-18-5C19H22ClN3OS2
N-[3-(1,3-Benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-pentynamide chemical structure, C22H23N3OS2, CAS 1369967-12-3
N-[3-(1,3-Benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-pentynamide
CAS 1369967-12-3C22H23N3OS2
3-(Benzo[D]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridin-2-amine chemical structure, C17H19N3S2, CAS 1163243-98-8
3-(Benzo[D]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridin-2-amine
CAS 1163243-98-8C17H19N3S2
Methyl 2-amino-3-(benzo[d]thiazol-2-yl)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C16H15N3O2S2, CAS 1251577-78-2
Methyl 2-amino-3-(benzo[d]thiazol-2-yl)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 1251577-78-2C16H15N3O2S2