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Murcko scaffold

2-Hydroxy-5-phenylpyridine scaffold

776 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
776
With full pages
32
Scaffold SMILES

O=c1ccc(-c2ccccc2)c[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Hydroxy-5-phenylpyridine page
Murcko scaffold O=c1ccc(-c2ccccc2)c[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 776 chemicals

1,2-Dihydro-6-methyl-2-oxo-5-phenyl-3-pyridinecarbonitrile chemical structure, C13H10N2O, CAS 4241-12-7
1,2-Dihydro-6-methyl-2-oxo-5-phenyl-3-pyridinecarbonitrile
CAS 4241-12-7C13H10N2O
3-Amino-6-methyl-5-phenyl-2(1H)-pyridinone chemical structure, C12H12N2O, CAS 80390-90-5
3-Amino-6-methyl-5-phenyl-2(1H)-pyridinone
CAS 80390-90-5C12H12N2O
Dpn 205-734 chemical structure, C14H9N3O, CAS 88594-78-9
Dpn 205-734
CAS 88594-78-9C14H9N3O
RG 14921 chemical structure, C11H9NO3, CAS 144909-21-7
RG 14921
CAS 144909-21-7C11H9NO3
4,6-Dimethyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile chemical structure, C14H12N2O, CAS 4241-19-4
4,6-Dimethyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile
CAS 4241-19-4C14H12N2O
2-Hydroxy-5-phenyl-nicotinonitrile chemical structure, C12H8N2O, CAS 35982-93-5
2-Hydroxy-5-phenyl-nicotinonitrile
CAS 35982-93-5C12H8N2O
2,6-Dihydroxy-5-phenylnicotinonitrile chemical structure, C12H8N2O2, CAS 10177-05-6
2,6-Dihydroxy-5-phenylnicotinonitrile
CAS 10177-05-6C12H8N2O2
6-Amino-2-hydroxy-5-phenylnicotinonitrile chemical structure, C12H9N3O, CAS 77609-05-3
6-Amino-2-hydroxy-5-phenylnicotinonitrile
CAS 77609-05-3C12H9N3O
5-(4-Chlorophenyl)-1-(2-methyl-2-propenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C16H13ClN2O, CAS 338423-27-1
5-(4-Chlorophenyl)-1-(2-methyl-2-propenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338423-27-1C16H13ClN2O
1-Allyl-5-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C15H11ClN2O, CAS 338423-51-1
1-Allyl-5-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338423-51-1C15H11ClN2O
5-(4-Chlorophenyl)-1-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H9ClN2O, CAS 338423-57-7
5-(4-Chlorophenyl)-1-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338423-57-7C13H9ClN2O
5-(4-Chlorophenyl)-1-isopropyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C15H13ClN2O, CAS 338423-60-2
5-(4-Chlorophenyl)-1-isopropyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338423-60-2C15H13ClN2O
1-Methyl-2-oxo-5-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H10N2O, CAS 130879-54-8
1-Methyl-2-oxo-5-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 130879-54-8C13H10N2O
5-(3-Chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C12H7ClN2O, CAS 338954-76-0
5-(3-Chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338954-76-0C12H7ClN2O
1-Allyl-5-(3-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C15H11ClN2O, CAS 338954-89-5
1-Allyl-5-(3-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338954-89-5C15H11ClN2O
5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C12H7ClN2O, CAS 35982-98-0
5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 35982-98-0C12H7ClN2O
2-Oxo-5-[3-(trifluoromethyl)phenyl]-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H7F3N2O, CAS 76053-36-6
2-Oxo-5-[3-(trifluoromethyl)phenyl]-1,2-dihydro-3-pyridinecarbonitrile
CAS 76053-36-6C13H7F3N2O
1-Allyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C16H11F3N2O, CAS 338964-43-5
1-Allyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,2-dihydro-3-pyridinecarbonitrile
CAS 338964-43-5C16H11F3N2O
1-(2-Methylpropyl)-2-oxo-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile chemical structure, C17H15F3N2O, CAS 338964-50-4
1-(2-Methylpropyl)-2-oxo-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile
CAS 338964-50-4C17H15F3N2O
5-(3-Chlorophenyl)-1-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H9ClN2O, CAS 338964-11-7
5-(3-Chlorophenyl)-1-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 338964-11-7C13H9ClN2O
1-Methyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C14H9F3N2O, CAS 338964-42-4
1-Methyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,2-dihydro-3-pyridinecarbonitrile
CAS 338964-42-4C14H9F3N2O
1-Allyl-2-oxo-5-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C15H12N2O, CAS 338795-40-7
1-Allyl-2-oxo-5-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 338795-40-7C15H12N2O
5-(4-Aminophenyl)-3-nitro-1H-pyridin-2-one chemical structure, C11H9N3O3, CAS 64606-10-6
5-(4-Aminophenyl)-3-nitro-1H-pyridin-2-one
CAS 64606-10-6C11H9N3O3
6-Methyl-2-oxo-5-phenyl-1,2-dihydro-pyridine-3,4-dicarbonitrile chemical structure, C14H9N3O, CAS 959095-94-4
6-Methyl-2-oxo-5-phenyl-1,2-dihydro-pyridine-3,4-dicarbonitrile
CAS 959095-94-4C14H9N3O