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Murcko scaffold

Ring system with 3 rings and 22 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
16
With full pages
3
Scaffold SMILES

c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

1-(2,4-Dimethylphenoxy)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-2-ol dihydrochloride chemical structure, C20H29Cl2N3O2, CAS 473265-47-3
1-(2,4-Dimethylphenoxy)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 473265-47-3C20H29Cl2N3O2
1-(4-Chloro-3-methylphenoxy)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-2-ol dihydrochloride chemical structure, C19H26Cl3N3O2, CAS 1211504-31-2
1-(4-Chloro-3-methylphenoxy)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 1211504-31-2C19H26Cl3N3O2
1-(4-Propylphenoxy)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-2-ol dihydrochloride chemical structure, C21H31Cl2N3O2, CAS 473266-90-9
1-(4-Propylphenoxy)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 473266-90-9C21H31Cl2N3O2
1-(2,6-Dimethylphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol chemical structure, C20H27N3O2, CAS 610281-37-3
1-(2,6-Dimethylphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol
CAS 610281-37-3C20H27N3O2
Methyl 4-[2-hydroxy-3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]benzoate chemical structure, C20H25N3O4, CAS 524724-12-7
Methyl 4-[2-hydroxy-3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]benzoate
CAS 524724-12-7C20H25N3O4
1-Acetyl-4-[2-hydroxy-3-(4-(2-pyridyl)piperazinyl)propoxy]-3-methoxybenzene chemical structure, C21H27N3O4, CAS 667891-15-8
1-Acetyl-4-[2-hydroxy-3-(4-(2-pyridyl)piperazinyl)propoxy]-3-methoxybenzene
CAS 667891-15-8C21H27N3O4
1-(4-{2-Hydroxy-3-[4-(pyridin-2-yl)piperazin-1-yl]propoxy}phenyl)propan-1-one chemical structure, C21H27N3O3, CAS 691398-51-3
1-(4-{2-Hydroxy-3-[4-(pyridin-2-yl)piperazin-1-yl]propoxy}phenyl)propan-1-one
CAS 691398-51-3C21H27N3O3
N-(4-(2-Hydroxy-3-(4-(pyridin-2-yl)piperazin-1-yl)propoxy)phenyl)-N-methylacetamide oxalate chemical structure, C23H30N4O7, CAS 1179394-49-0
N-(4-(2-Hydroxy-3-(4-(pyridin-2-yl)piperazin-1-yl)propoxy)phenyl)-N-methylacetamide oxalate
CAS 1179394-49-0C23H30N4O7
1-(4-Nitrophenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol chemical structure, C18H22N4O4, CAS 133863-89-5
1-(4-Nitrophenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol
CAS 133863-89-5C18H22N4O4
1-(4-tert-Butylphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol chemical structure, C22H31N3O2, CAS 610281-32-8
1-(4-tert-Butylphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol
CAS 610281-32-8C22H31N3O2
Acetamide, N-[3-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]phenyl]- chemical structure, C20H26N4O2, CAS 114597-74-9
Acetamide, N-[3-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]phenyl]-
CAS 114597-74-9C20H26N4O2
1-(4-(Pyridin-2-yl)piperazin-1-yl)-3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propan-2-ol dihydrochloride chemical structure, C26H41Cl2N3O2, CAS 1215685-03-2
1-(4-(Pyridin-2-yl)piperazin-1-yl)-3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propan-2-ol dihydrochloride
CAS 1215685-03-2C26H41Cl2N3O2
1-(4-(2-Hydroxy-3-(4-(pyridin-2-yl)piperazin-1-yl)propoxy)phenyl)propan-1-one dihydrochloride chemical structure, C21H29Cl2N3O3, CAS 1215647-93-0
1-(4-(2-Hydroxy-3-(4-(pyridin-2-yl)piperazin-1-yl)propoxy)phenyl)propan-1-one dihydrochloride
CAS 1215647-93-0C21H29Cl2N3O3
1-(4-(Pyridin-2-yl)piperazin-1-yl)-3-(o-tolyloxy)propan-2-ol dihydrochloride chemical structure, C19H27Cl2N3O2, CAS 1215542-57-6
1-(4-(Pyridin-2-yl)piperazin-1-yl)-3-(o-tolyloxy)propan-2-ol dihydrochloride
CAS 1215542-57-6C19H27Cl2N3O2
Benzenamine,4-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]- chemical structure, C18H24N4O, CAS 3973-84-0
Benzenamine,4-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]-
CAS 3973-84-0C18H24N4O
1-(4-Fluorophenoxy)-3-(4-{3-[hydroxy(oxido)amino]pyridin-2-yl}piperazin-1-yl)propan-2-ol chemical structure, C18H21FN4O4, CAS 1858255-69-2
1-(4-Fluorophenoxy)-3-(4-{3-[hydroxy(oxido)amino]pyridin-2-yl}piperazin-1-yl)propan-2-ol
CAS 1858255-69-2C18H21FN4O4