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Murcko scaffold

Ring system with 3 rings and 21 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
16
With full pages
2
Scaffold SMILES

O=C1NC(=O)N(c2ccccc2)C(=O)C1=Cc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=O)N(c2ccccc2)C(=O)C1=Cc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

(5Z)-1-(3-Methoxyphenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C17H14N2O4S, CAS 346638-07-1
(5Z)-1-(3-Methoxyphenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 346638-07-1C17H14N2O4S
(5Z)-1-(2-Methoxyphenyl)-5-[(3-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C17H14N2O4S, CAS 372506-63-3
(5Z)-1-(2-Methoxyphenyl)-5-[(3-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 372506-63-3C17H14N2O4S
(5Z)-1-(2,5-Dimethoxyphenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C18H16N2O5S, CAS 346637-14-7
(5Z)-1-(2,5-Dimethoxyphenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 346637-14-7C18H16N2O5S
4-[(5Z)-5-[(5-Methylthiophen-2-yl)methylidene]-2,4,6-trioxo-1,3-diazinan-1-yl]benzoic acid chemical structure, C17H12N2O5S, CAS 346636-99-5
4-[(5Z)-5-[(5-Methylthiophen-2-yl)methylidene]-2,4,6-trioxo-1,3-diazinan-1-yl]benzoic acid
CAS 346636-99-5C17H12N2O5S
(5Z)-1-(4-Chlorophenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C16H11ClN2O3S, CAS 342016-81-3
(5Z)-1-(4-Chlorophenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 342016-81-3C16H11ClN2O3S
(5E)-1-(2-Methoxyphenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C17H14N2O4S, CAS 352343-23-8
(5E)-1-(2-Methoxyphenyl)-5-[(5-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 352343-23-8C17H14N2O4S
(5Z)-5-[(5-Bromothiophen-2-yl)methylidene]-1-(3-methoxyphenyl)-1,3-diazinane-2,4,6-trione chemical structure, C16H11BrN2O4S, CAS 346612-59-7
(5Z)-5-[(5-Bromothiophen-2-yl)methylidene]-1-(3-methoxyphenyl)-1,3-diazinane-2,4,6-trione
CAS 346612-59-7C16H11BrN2O4S
(5Z)-1-(2-Methoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C16H11N3O6S, CAS 372502-68-6
(5Z)-1-(2-Methoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 372502-68-6C16H11N3O6S
(5Z)-1-(3-Methoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C16H11N3O6S, CAS 346612-61-1
(5Z)-1-(3-Methoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 346612-61-1C16H11N3O6S
(5E)-1-(2,5-Dimethoxyphenyl)-5-(thiophen-2-ylmethylidene)-1,3-diazinane-2,4,6-trione chemical structure, C17H14N2O5S, CAS 352343-00-1
(5E)-1-(2,5-Dimethoxyphenyl)-5-(thiophen-2-ylmethylidene)-1,3-diazinane-2,4,6-trione
CAS 352343-00-1C17H14N2O5S
(5Z)-1-(4-Chlorophenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C15H8ClN3O5S, CAS 372975-28-5
(5Z)-1-(4-Chlorophenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 372975-28-5C15H8ClN3O5S
(5Z)-1-(2,5-Dimethoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C17H13N3O7S, CAS 374617-58-0
(5Z)-1-(2,5-Dimethoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 374617-58-0C17H13N3O7S
(5E)-5-[(4-Bromothiophen-2-yl)methylidene]-1-(2,3-dichlorophenyl)-1,3-diazinane-2,4,6-trione chemical structure, C15H7BrCl2N2O3S, CAS 677294-99-4
(5E)-5-[(4-Bromothiophen-2-yl)methylidene]-1-(2,3-dichlorophenyl)-1,3-diazinane-2,4,6-trione
CAS 677294-99-4C15H7BrCl2N2O3S
(5Z)-1-(4-Methylphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C16H11N3O5S, CAS 346612-41-7
(5Z)-1-(4-Methylphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 346612-41-7C16H11N3O5S
(5E)-5-[(5-Bromothiophen-2-yl)methylidene]-1-(3,4-dimethylphenyl)-1,3-diazinane-2,4,6-trione chemical structure, C17H13BrN2O3S, CAS 347388-00-5
(5E)-5-[(5-Bromothiophen-2-yl)methylidene]-1-(3,4-dimethylphenyl)-1,3-diazinane-2,4,6-trione
CAS 347388-00-5C17H13BrN2O3S
(5E)-1-(3,4-Dimethylphenyl)-5-[(3-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C18H16N2O3S, CAS 426246-32-4
(5E)-1-(3,4-Dimethylphenyl)-5-[(3-methylthiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione
CAS 426246-32-4C18H16N2O3S