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Murcko scaffold

Ring system with 4 rings and 20 atoms

21 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
21
With full pages
3
Scaffold SMILES

c1ccc(-c2cnn3c(-n4ccnc4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(-n4ccnc4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

5-(tert-Butyl)-7-(1H-imidazol-1-yl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H21N5, CAS 849921-33-1
5-(tert-Butyl)-7-(1H-imidazol-1-yl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 849921-33-1C20H21N5
5-(tert-Butyl)-3-(4-chlorophenyl)-2-methyl-7-(2-methyl-1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H22ClN5, CAS 850762-30-0
5-(tert-Butyl)-3-(4-chlorophenyl)-2-methyl-7-(2-methyl-1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 850762-30-0C21H22ClN5
3-(4-Chlorophenyl)-7-(1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C17H14ClN5, CAS 849911-11-1
3-(4-Chlorophenyl)-7-(1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 849911-11-1C17H14ClN5
3-(4-Chlorophenyl)-7-(2-ethyl-1H-imidazol-1-yl)-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C18H16ClN5, CAS 896831-82-6
3-(4-Chlorophenyl)-7-(2-ethyl-1H-imidazol-1-yl)-5-methylpyrazolo[1,5-a]pyrimidine
CAS 896831-82-6C18H16ClN5
5-tert-Butyl-3-(4-chlorophenyl)-7-(2-ethyl-1-imidazolyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H22ClN5, CAS 896843-20-2
5-tert-Butyl-3-(4-chlorophenyl)-7-(2-ethyl-1-imidazolyl)pyrazolo[1,5-a]pyrimidine
CAS 896843-20-2C21H22ClN5
5-(tert-Butyl)-3-(4-chlorophenyl)-7-(1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H18ClN5, CAS 896853-72-8
5-(tert-Butyl)-3-(4-chlorophenyl)-7-(1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896853-72-8C19H18ClN5
5-(tert-Butyl)-3-(4-chlorophenyl)-7-(2-methyl-1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H20ClN5, CAS 896856-15-8
5-(tert-Butyl)-3-(4-chlorophenyl)-7-(2-methyl-1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896856-15-8C20H20ClN5
7-(1H-Imidazol-1-yl)-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C18H17N5O, CAS 902016-81-3
7-(1H-Imidazol-1-yl)-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 902016-81-3C18H17N5O
5-(tert-Butyl)-7-(2-methyl-1H-imidazol-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H21N5, CAS 902022-84-8
5-(tert-Butyl)-7-(2-methyl-1H-imidazol-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 902022-84-8C20H21N5
7-(2-Ethyl-1H-imidazol-1-yl)-5-isopropyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H21N5, CAS 900295-76-3
7-(2-Ethyl-1H-imidazol-1-yl)-5-isopropyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 900295-76-3C20H21N5
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-7-(2-methyl-1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H21N5O2, CAS 900869-35-4
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-7-(2-methyl-1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900869-35-4C20H21N5O2
7-(1H-Imidazol-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C18H17N5, CAS 900890-77-9
7-(1H-Imidazol-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 900890-77-9C18H17N5
3-(3,4-Dimethoxyphenyl)-7-(2-ethyl-1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C21H23N5O2, CAS 900883-89-8
3-(3,4-Dimethoxyphenyl)-7-(2-ethyl-1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 900883-89-8C21H23N5O2
3-(3,4-Dimethoxyphenyl)-7-(1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C19H19N5O2, CAS 900896-05-1
3-(3,4-Dimethoxyphenyl)-7-(1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 900896-05-1C19H19N5O2
7-(2-Ethyl-1H-imidazol-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C20H21N5, CAS 900898-37-5
7-(2-Ethyl-1H-imidazol-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 900898-37-5C20H21N5
3-(2-Chlorophenyl)-7-(2-ethyl-1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C19H18ClN5, CAS 900887-89-0
3-(2-Chlorophenyl)-7-(2-ethyl-1H-imidazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 900887-89-0C19H18ClN5
7-(1H-Imidazol-1-yl)-5-isopropyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C18H17N5, CAS 902044-34-2
7-(1H-Imidazol-1-yl)-5-isopropyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 902044-34-2C18H17N5
7-(2-Methyl-1H-imidazol-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C19H19N5, CAS 902023-50-1
7-(2-Methyl-1H-imidazol-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 902023-50-1C19H19N5
5-Isopropyl-7-(2-methyl-1H-imidazol-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H19N5, CAS 902024-32-2
5-Isopropyl-7-(2-methyl-1H-imidazol-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 902024-32-2C19H19N5
5-(tert-Butyl)-3-(2-chlorophenyl)-7-(1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H18ClN5, CAS 902311-21-1
5-(tert-Butyl)-3-(2-chlorophenyl)-7-(1H-imidazol-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 902311-21-1C19H18ClN5
2-Ethyl-7-(1H-imidazol-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C18H17N5, CAS 890620-12-9
2-Ethyl-7-(1H-imidazol-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 890620-12-9C18H17N5