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Murcko scaffold

Ring system with 4 rings and 20 atoms

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
32
With full pages
2
Scaffold SMILES

c1ccc(-c2cnn3c(N4CCCC4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(N4CCCC4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

2,5-Dimethyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H20N4, CAS 877622-07-6
2,5-Dimethyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 877622-07-6C18H20N4
5-Isopropyl-2-methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H24N4, CAS 896835-54-4
5-Isopropyl-2-methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896835-54-4C20H24N4
2-Methyl-3-phenyl-5-propyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H24N4, CAS 896850-50-3
2-Methyl-3-phenyl-5-propyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896850-50-3C20H24N4
3-(4-Chlorophenyl)-5-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C17H17ClN4, CAS 896595-59-8
3-(4-Chlorophenyl)-5-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896595-59-8C17H17ClN4
5-(tert-Butyl)-3-(4-chlorophenyl)-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H23ClN4, CAS 896808-85-8
5-(tert-Butyl)-3-(4-chlorophenyl)-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896808-85-8C20H23ClN4
5-(tert-Butyl)-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H24N4, CAS 896857-70-8
5-(tert-Butyl)-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896857-70-8C20H24N4
5-(tert-Butyl)-2-methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H26N4, CAS 850192-42-6
5-(tert-Butyl)-2-methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 850192-42-6C21H26N4
3-(4-Chlorophenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H19ClN4, CAS 850228-80-7
3-(4-Chlorophenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 850228-80-7C18H19ClN4
5-Methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C17H18N4, CAS 850244-88-1
5-Methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 850244-88-1C17H18N4
5-tert-Butyl-3-(4-chlorophenyl)-2-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H25ClN4, CAS 850743-45-2
5-tert-Butyl-3-(4-chlorophenyl)-2-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 850743-45-2C21H25ClN4
6-Ethyl-2,5-dimethyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H24N4, CAS 896079-16-6
6-Ethyl-2,5-dimethyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896079-16-6C20H24N4
3-(2-Methoxyphenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H22N4O, CAS 879589-86-3
3-(2-Methoxyphenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 879589-86-3C19H22N4O
5,6-Dimethyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H20N4, CAS 900892-31-1
5,6-Dimethyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900892-31-1C18H20N4
3-(2-Chlorophenyl)-5-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C17H17ClN4, CAS 900878-29-7
3-(2-Chlorophenyl)-5-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900878-29-7C17H17ClN4
3-Phenyl-5-(propan-2-yl)-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H22N4, CAS 900898-65-9
3-Phenyl-5-(propan-2-yl)-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900898-65-9C19H22N4
6-Allyl-5-methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H22N4, CAS 900886-14-8
6-Allyl-5-methyl-3-phenyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900886-14-8C20H22N4
5-Methyl-3-(4-methylphenyl)-7-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidine chemical structure, C18H20N4, CAS 902018-45-5
5-Methyl-3-(4-methylphenyl)-7-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidine
CAS 902018-45-5C18H20N4
5-Methyl-3-phenyl-7-(pyrrolidin-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H17F3N4, CAS 902036-06-0
5-Methyl-3-phenyl-7-(pyrrolidin-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 902036-06-0C18H17F3N4
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H24N4O2, CAS 902022-06-4
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 902022-06-4C20H24N4O2
3-(2-Methoxyphenyl)-5-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H20N4O, CAS 902321-83-9
3-(2-Methoxyphenyl)-5-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 902321-83-9C18H20N4O
3-Phenyl-5-propyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H22N4, CAS 900258-19-7
3-Phenyl-5-propyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900258-19-7C19H22N4
5-(tert-Butyl)-7-(pyrrolidin-1-yl)-3-(p-tolyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H26N4, CAS 902302-81-2
5-(tert-Butyl)-7-(pyrrolidin-1-yl)-3-(p-tolyl)pyrazolo[1,5-a]pyrimidine
CAS 902302-81-2C21H26N4
3-(2-Chlorophenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H19ClN4, CAS 890633-46-2
3-(2-Chlorophenyl)-2,5-dimethyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 890633-46-2C18H19ClN4
2,5-Dimethyl-3-(4-methylphenyl)-7-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidine chemical structure, C19H22N4, CAS 890638-62-7
2,5-Dimethyl-3-(4-methylphenyl)-7-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidine
CAS 890638-62-7C19H22N4