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Murcko scaffold

Ring system with 4 rings and 20 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
12
With full pages
3
Scaffold SMILES

c1ccc(-n2ncc3c(N4CCCC4)ncnc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-n2ncc3c(N4CCCC4)ncnc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

1-(2,4-Dimethylphenyl)-4-pyrrolidin-1-ylpyrazolo[3,4-d]pyrimidine chemical structure, C17H19N5, CAS 393845-07-3
1-(2,4-Dimethylphenyl)-4-pyrrolidin-1-ylpyrazolo[3,4-d]pyrimidine
CAS 393845-07-3C17H19N5
1-(4-Chlorophenyl)-4-pyrrolidin-1-ylpyrazolo[3,4-d]pyrimidine chemical structure, C15H14ClN5, CAS 393845-05-1
1-(4-Chlorophenyl)-4-pyrrolidin-1-ylpyrazolo[3,4-d]pyrimidine
CAS 393845-05-1C15H14ClN5
1-(3-Methylphenyl)-4-pyrrolidin-1-ylpyrazolo[3,4-d]pyrimidine chemical structure, C16H17N5, CAS 305337-37-5
1-(3-Methylphenyl)-4-pyrrolidin-1-ylpyrazolo[3,4-d]pyrimidine
CAS 305337-37-5C16H17N5
Methyl 1-phenyl-4-(1-pyrrolidinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl sulfide chemical structure, C16H17N5S, CAS 339106-41-1
Methyl 1-phenyl-4-(1-pyrrolidinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl sulfide
CAS 339106-41-1C16H17N5S
1-(4-Methylphenyl)-6-(methylsulfanyl)-4-(1-pyrrolidinyl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19N5S, CAS 478247-43-7
1-(4-Methylphenyl)-6-(methylsulfanyl)-4-(1-pyrrolidinyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 478247-43-7C17H19N5S
1-(2-Methylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C16H17N5, CAS 955306-15-7
1-(2-Methylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 955306-15-7C16H17N5
1-(3,4-Dimethylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19N5, CAS 890888-99-0
1-(3,4-Dimethylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 890888-99-0C17H19N5
1-(3,5-Dimethylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19N5, CAS 955320-11-3
1-(3,5-Dimethylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 955320-11-3C17H19N5
1-(3,4-Difluorophenyl)-4-pyrrolidinylpyrazolo[5,4-d]pyrimidine chemical structure, C15H13F2N5, CAS 921112-57-4
1-(3,4-Difluorophenyl)-4-pyrrolidinylpyrazolo[5,4-d]pyrimidine
CAS 921112-57-4C15H13F2N5
1-(4-Chloro-2-methylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C16H16ClN5, CAS 921539-24-4
1-(4-Chloro-2-methylphenyl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 921539-24-4C16H16ClN5
[(2R)-1-[1-(3-Chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]pyrrolidin-2-yl]methanol chemical structure, C17H18ClN5O, CAS 1461689-24-6
[(2R)-1-[1-(3-Chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]pyrrolidin-2-yl]methanol
CAS 1461689-24-6C17H18ClN5O
{1-[1-(3-Chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]pyrrolidin-2-yl}methanol chemical structure, C17H18ClN5O, CAS 1955514-35-8
{1-[1-(3-Chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]pyrrolidin-2-yl}methanol
CAS 1955514-35-8C17H18ClN5O