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Murcko scaffold

Ring system with 4 rings and 20 atoms

33 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
33
With full pages
1
Scaffold SMILES

c1ccc(-c2cnn3c(-n4cccn4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(-n4cccn4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

Ethyl 5-amino-1-(5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrazole-4-carboxylate chemical structure, C19H18N6O2, CAS 850764-98-6
Ethyl 5-amino-1-(5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrazole-4-carboxylate
CAS 850764-98-6C19H18N6O2
Ethyl 5-amino-1-(2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrazole-4-carboxylate chemical structure, C20H20N6O2, CAS 909861-19-4
Ethyl 5-amino-1-(2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrazole-4-carboxylate
CAS 909861-19-4C20H20N6O2
7-(3,5-Dimethyl-1-pyrazolyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C18H17N5, CAS 908230-38-6
7-(3,5-Dimethyl-1-pyrazolyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 908230-38-6C18H17N5
5-(tert-Butyl)-7-(3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C21H23N5, CAS 957028-96-5
5-(tert-Butyl)-7-(3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 957028-96-5C21H23N5
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C21H23N5, CAS 957028-90-9
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 957028-90-9C21H23N5
Ethyl 5-amino-1-(3-(4-chlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrazole-4-carboxylate chemical structure, C20H19ClN6O2, CAS 850157-02-7
Ethyl 5-amino-1-(3-(4-chlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrazole-4-carboxylate
CAS 850157-02-7C20H19ClN6O2
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C21H23N5, CAS 957013-77-3
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 957013-77-3C21H23N5
3-(4-Chlorophenyl)-7-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C19H18ClN5, CAS 850800-52-1
3-(4-Chlorophenyl)-7-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 850800-52-1C19H18ClN5
5-tert-Butyl-3-(4-chlorophenyl)-7-(3,5-dimethylpyrazol-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H22ClN5, CAS 956048-99-0
5-tert-Butyl-3-(4-chlorophenyl)-7-(3,5-dimethylpyrazol-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 956048-99-0C21H22ClN5
5-tert-Butyl-7-(3,5-dimethyl-1H-pyrazol-1-yl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C22H25N5, CAS 1004019-04-8
5-tert-Butyl-7-(3,5-dimethyl-1H-pyrazol-1-yl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 1004019-04-8C22H25N5
1-[5-tert-Butyl-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl]-3,5-dimethyl-1H-pyrazole chemical structure, C22H24ClN5, CAS 1003081-35-3
1-[5-tert-Butyl-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl]-3,5-dimethyl-1H-pyrazole
CAS 1003081-35-3C22H24ClN5
Ethyl 5-amino-1-{5-tert-butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl}-1H-pyrazole-4-carboxylate chemical structure, C23H26N6O2, CAS 958944-07-5
Ethyl 5-amino-1-{5-tert-butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl}-1H-pyrazole-4-carboxylate
CAS 958944-07-5C23H26N6O2
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H19N5, CAS 958943-99-2
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 958943-99-2C19H19N5
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-5,6-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H19N5, CAS 956624-95-6
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-5,6-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 956624-95-6C19H19N5
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-methyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H19N5, CAS 956375-46-5
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-methyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidine
CAS 956375-46-5C19H19N5
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C20H21N5O, CAS 879574-86-4
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 879574-86-4C20H21N5O
Ethyl 5-amino-1-[3-(4-fluorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate chemical structure, C20H16F4N6O2, CAS 956941-68-7
Ethyl 5-amino-1-[3-(4-fluorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate
CAS 956941-68-7C20H16F4N6O2
Ethyl 5-amino-1-[3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate chemical structure, C19H17FN6O2, CAS 1005961-81-8
Ethyl 5-amino-1-[3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate
CAS 1005961-81-8C19H17FN6O2
Ethyl 5-amino-1-[3-(2,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate chemical structure, C20H18Cl2N6O2, CAS 1006268-06-9
Ethyl 5-amino-1-[3-(2,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate
CAS 1006268-06-9C20H18Cl2N6O2
3-(4-Chlorophenyl)-7-(3,5-dimethyl-1H-pyrazol-1-yl)-2-ethyl-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H20ClN5, CAS 1010867-22-7
3-(4-Chlorophenyl)-7-(3,5-dimethyl-1H-pyrazol-1-yl)-2-ethyl-5-methylpyrazolo[1,5-a]pyrimidine
CAS 1010867-22-7C20H20ClN5
Ethyl 5-amino-1-[3-(4-chlorophenyl)-2-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate chemical structure, C21H21ClN6O2, CAS 1010869-74-5
Ethyl 5-amino-1-[3-(4-chlorophenyl)-2-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate
CAS 1010869-74-5C21H21ClN6O2
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-ethyl-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H20FN5, CAS 1010870-25-3
7-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-ethyl-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine
CAS 1010870-25-3C20H20FN5
Ethyl 5-amino-1-[2-ethyl-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate chemical structure, C21H21FN6O2, CAS 1010863-84-9
Ethyl 5-amino-1-[2-ethyl-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate
CAS 1010863-84-9C21H21FN6O2
Ethyl 5-amino-1-[3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate chemical structure, C19H17ClN6O2, CAS 1020502-90-2
Ethyl 5-amino-1-[3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-1H-pyrazole-4-carboxylate
CAS 1020502-90-2C19H17ClN6O2