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Murcko scaffold

Ring system with 3 rings and 22 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
42
With full pages
4
Scaffold SMILES

c1ccc(SCCCN2CCN(c3ccccc3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(SCCCN2CCN(c3ccccc3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

1-Propanone, 1-(4-((2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)thio)phenyl)-, (±)- chemical structure, C22H28N2O2S, CAS 36115-60-3
1-Propanone, 1-(4-((2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)thio)phenyl)-, (±)-
CAS 36115-60-3C22H28N2O2S
1-(4-Phenylpiperazin-1-yl)-3-(phenylsulfanyl)propan-2-ol chemical structure, C19H24N2OS, CAS 66307-18-4
1-(4-Phenylpiperazin-1-yl)-3-(phenylsulfanyl)propan-2-ol
CAS 66307-18-4C19H24N2OS
1-Piperazineethanol, alpha-phenylthiomethyl-4-(o-tolyl)- chemical structure, C20H26N2OS, CAS 66307-35-5
1-Piperazineethanol, alpha-phenylthiomethyl-4-(o-tolyl)-
CAS 66307-35-5C20H26N2OS
Propiophenone, 4'-((3-(4-phenyl-1-piperazinyl)propyl)thio)-, dihydrochloride chemical structure, C22H30Cl2N2OS, CAS 65976-24-1
Propiophenone, 4'-((3-(4-phenyl-1-piperazinyl)propyl)thio)-, dihydrochloride
CAS 65976-24-1C22H30Cl2N2OS
1-Piperazineethanol, 4-phenyl-alpha-(p-tolylthiomethyl)- chemical structure, C20H26N2OS, CAS 66307-52-6
1-Piperazineethanol, 4-phenyl-alpha-(p-tolylthiomethyl)-
CAS 66307-52-6C20H26N2OS
1-[(4-Chlorophenyl)sulfanyl]-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol chemical structure, C20H22ClF3N2OS, CAS 338422-14-3
1-[(4-Chlorophenyl)sulfanyl]-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol
CAS 338422-14-3C20H22ClF3N2OS
1-[4-(3-Chlorophenyl)piperazino]-3-[(3-chlorophenyl)sulfanyl]-2-propanol chemical structure, C19H22Cl2N2OS, CAS 338422-12-1
1-[4-(3-Chlorophenyl)piperazino]-3-[(3-chlorophenyl)sulfanyl]-2-propanol
CAS 338422-12-1C19H22Cl2N2OS
1-[(3-Methylphenyl)sulfanyl]-3-(4-phenylpiperazino)-2-propanol chemical structure, C20H26N2OS, CAS 338421-70-8
1-[(3-Methylphenyl)sulfanyl]-3-(4-phenylpiperazino)-2-propanol
CAS 338421-70-8C20H26N2OS
1-[4-(2-Fluorophenyl)piperazino]-3-[(4-fluorophenyl)sulfanyl]-2-propanol chemical structure, C19H22F2N2OS, CAS 338421-88-8
1-[4-(2-Fluorophenyl)piperazino]-3-[(4-fluorophenyl)sulfanyl]-2-propanol
CAS 338421-88-8C19H22F2N2OS
1-[(2,6-Dichlorophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol chemical structure, C19H21Cl2FN2OS, CAS 338422-01-8
1-[(2,6-Dichlorophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol
CAS 338422-01-8C19H21Cl2FN2OS
1-[(2-Chlorophenyl)sulfanyl]-3-(4-phenylpiperazino)-2-propanol chemical structure, C19H23ClN2OS, CAS 338421-69-5
1-[(2-Chlorophenyl)sulfanyl]-3-(4-phenylpiperazino)-2-propanol
CAS 338421-69-5C19H23ClN2OS
1-[(4-Bromophenyl)sulfanyl]-3-[4-(3-chlorophenyl)piperazino]-2-propanol chemical structure, C19H22BrClN2OS, CAS 338422-17-6
1-[(4-Bromophenyl)sulfanyl]-3-[4-(3-chlorophenyl)piperazino]-2-propanol
CAS 338422-17-6C19H22BrClN2OS
1-[(4-Methylphenyl)sulfanyl]-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol chemical structure, C21H25F3N2OS, CAS 338422-13-2
1-[(4-Methylphenyl)sulfanyl]-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol
CAS 338422-13-2C21H25F3N2OS
1-[4-(2-Fluorophenyl)piperazino]-3-[(4-methylphenyl)sulfanyl]-2-propanol chemical structure, C20H25FN2OS, CAS 338421-84-4
1-[4-(2-Fluorophenyl)piperazino]-3-[(4-methylphenyl)sulfanyl]-2-propanol
CAS 338421-84-4C20H25FN2OS
1-[(4-Chlorophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol chemical structure, C19H22ClFN2OS, CAS 338421-73-1
1-[(4-Chlorophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol
CAS 338421-73-1C19H22ClFN2OS
1-(4-Phenylpiperazino)-3-{[3-(trifluoromethyl)phenyl]sulfanyl}-2-propanol chemical structure, C20H23F3N2OS, CAS 338421-67-3
1-(4-Phenylpiperazino)-3-{[3-(trifluoromethyl)phenyl]sulfanyl}-2-propanol
CAS 338421-67-3C20H23F3N2OS
1-[4-(3-Chlorophenyl)piperazino]-3-[(4-chlorophenyl)sulfanyl]-2-propanol chemical structure, C19H22Cl2N2OS, CAS 338422-07-4
1-[4-(3-Chlorophenyl)piperazino]-3-[(4-chlorophenyl)sulfanyl]-2-propanol
CAS 338422-07-4C19H22Cl2N2OS
1-[(3-Chlorophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol chemical structure, C19H22ClFN2OS, CAS 338421-82-2
1-[(3-Chlorophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol
CAS 338421-82-2C19H22ClFN2OS
1-[(4-Bromophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol chemical structure, C19H22BrFN2OS, CAS 338421-99-1
1-[(4-Bromophenyl)sulfanyl]-3-[4-(4-fluorophenyl)piperazino]-2-propanol
CAS 338421-99-1C19H22BrFN2OS
1-[4-(4-Fluorophenyl)piperazino]-3-[(4-fluorophenyl)sulfanyl]-2-propanol chemical structure, C19H22F2N2OS, CAS 338421-74-2
1-[4-(4-Fluorophenyl)piperazino]-3-[(4-fluorophenyl)sulfanyl]-2-propanol
CAS 338421-74-2C19H22F2N2OS
1-[4-(3-Chlorophenyl)piperazino]-3-[(2-chlorophenyl)sulfanyl]-2-propanol chemical structure, C19H22Cl2N2OS, CAS 338422-11-0
1-[4-(3-Chlorophenyl)piperazino]-3-[(2-chlorophenyl)sulfanyl]-2-propanol
CAS 338422-11-0C19H22Cl2N2OS
1-[(4-Chlorophenyl)sulfanyl]-3-(4-phenylpiperazino)-2-propanol chemical structure, C19H23ClN2OS, CAS 338421-66-2
1-[(4-Chlorophenyl)sulfanyl]-3-(4-phenylpiperazino)-2-propanol
CAS 338421-66-2C19H23ClN2OS
1-[4-(3-Chlorophenyl)piperazino]-3-[(4-fluorophenyl)sulfanyl]-2-propanol chemical structure, C19H22ClFN2OS, CAS 338422-09-6
1-[4-(3-Chlorophenyl)piperazino]-3-[(4-fluorophenyl)sulfanyl]-2-propanol
CAS 338422-09-6C19H22ClFN2OS
1-[4-(4-Fluorophenyl)piperazino]-3-(phenylsulfanyl)-2-propanol chemical structure, C19H23FN2OS, CAS 338421-98-0
1-[4-(4-Fluorophenyl)piperazino]-3-(phenylsulfanyl)-2-propanol
CAS 338421-98-0C19H23FN2OS