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Murcko scaffold

Ring system with 3 rings and 19 atoms

20 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 20
With full pages: 5

Scaffold SMILES

O=C(C=Cc1ccccc1)n1cnc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)n1cnc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

(E)-1-(1H-Benzo[d]imidazol-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one chemical structure, C16H11FN2O, CAS 325850-70-2

(E)-1-(1H-Benzo[d]imidazol-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one

CAS 325850-70-2C₁₆H₁₁FN₂O

(E)-3-(3-Nitrophenyl)-1-(2-prop-2-ynylsulfanylbenzimidazol-1-yl)prop-2-en-1-one chemical structure, C19H13N3O3S, CAS 324779-66-0

(E)-3-(3-Nitrophenyl)-1-(2-prop-2-ynylsulfanylbenzimidazol-1-yl)prop-2-en-1-one

CAS 324779-66-0C₁₉H₁₃N₃O₃S

(E)-3-(3,4-Dimethoxyphenyl)-1-(2-ethylsulfanylbenzimidazol-1-yl)prop-2-en-1-one chemical structure, C20H20N2O3S, CAS 1164549-68-1

(E)-3-(3,4-Dimethoxyphenyl)-1-(2-ethylsulfanylbenzimidazol-1-yl)prop-2-en-1-one

CAS 1164549-68-1C₂₀H₂₀N₂O₃S

(E)-1-(Benzimidazol-1-yl)-3-(2-chlorophenyl)prop-2-en-1-one chemical structure, C16H11ClN2O, CAS 349422-93-1

(E)-1-(Benzimidazol-1-yl)-3-(2-chlorophenyl)prop-2-en-1-one

CAS 349422-93-1C₁₆H₁₁ClN₂O

(2E)-1-[2-(Ethylsulfanyl)-1H-benzimidazol-1-yl]-3-(4-fluorophenyl)prop-2-en-1-one chemical structure, C18H15FN2OS, CAS 327094-33-7

(2E)-1-[2-(Ethylsulfanyl)-1H-benzimidazol-1-yl]-3-(4-fluorophenyl)prop-2-en-1-one

CAS 327094-33-7C₁₈H₁₅FN₂OS

1-Benzoimidazol-1-yl-3-phenyl-propenone chemical structure, C16H12N2O, CAS 370084-07-4

1-Benzoimidazol-1-yl-3-phenyl-propenone

CAS 370084-07-4C₁₆H₁₂N₂O

(E)-3-(4-Methoxyphenyl)-1-(2-(prop-2-yn-1-ylthio)-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one chemical structure, C20H16N2O2S, CAS 328540-63-2

(E)-3-(4-Methoxyphenyl)-1-(2-(prop-2-yn-1-ylthio)-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one

CAS 328540-63-2C₂₀H₁₆N₂O₂S

(E)-3-(4-Fluorophenyl)-1-(2-(prop-2-yn-1-ylthio)-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one chemical structure, C19H13FN2OS, CAS 325850-76-8

(E)-3-(4-Fluorophenyl)-1-(2-(prop-2-yn-1-ylthio)-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one

CAS 325850-76-8C₁₉H₁₃FN₂OS

(E)-3-(3,4-Dimethoxyphenyl)-1-(2-prop-2-ynylsulfanylbenzimidazol-1-yl)prop-2-en-1-one chemical structure, C21H18N2O3S, CAS 324779-91-1

(E)-3-(3,4-Dimethoxyphenyl)-1-(2-prop-2-ynylsulfanylbenzimidazol-1-yl)prop-2-en-1-one

CAS 324779-91-1C₂₁H₁₈N₂O₃S

(E)-1-(5,6-Dimethylbenzimidazol-1-yl)-3-phenylprop-2-en-1-one chemical structure, C18H16N2O, CAS 1609007-30-8

(E)-1-(5,6-Dimethylbenzimidazol-1-yl)-3-phenylprop-2-en-1-one

CAS 1609007-30-8C₁₈H₁₆N₂O

(E)-1-(5,6-Dimethylbenzimidazol-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C21H22N2O4, CAS 432511-69-8

(E)-1-(5,6-Dimethylbenzimidazol-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

CAS 432511-69-8C₂₁H₂₂N₂O₄

(E)-1-(Benzimidazol-1-yl)-3-(3-chlorophenyl)prop-2-en-1-one chemical structure, C16H11ClN2O, CAS 690966-79-1

(E)-1-(Benzimidazol-1-yl)-3-(3-chlorophenyl)prop-2-en-1-one

CAS 690966-79-1C₁₆H₁₁ClN₂O

2-(Allylthio)-1-[3-(3,4,5-trimethoxyphenyl)acryloyl]-1H-benzimidazole chemical structure, C22H22N2O4S, CAS 1164459-49-7

2-(Allylthio)-1-[3-(3,4,5-trimethoxyphenyl)acryloyl]-1H-benzimidazole

CAS 1164459-49-7C₂₂H₂₂N₂O₄S

2-(Allylthio)-1-[3-(3,4-dimethoxyphenyl)acryloyl]-1H-benzimidazole chemical structure, C21H20N2O3S, CAS 1164458-12-1

2-(Allylthio)-1-[3-(3,4-dimethoxyphenyl)acryloyl]-1H-benzimidazole

CAS 1164458-12-1C₂₁H₂₀N₂O₃S

(E)-1-(Benzimidazol-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one chemical structure, C16H11N3O3, CAS 71322-75-3

(E)-1-(Benzimidazol-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one

CAS 71322-75-3C₁₆H₁₁N₃O₃

(2E)-1-(1H-Benzimidazol-1-yl)-3-(2-methoxyphenyl)prop-2-en-1-one chemical structure, C17H14N2O2, CAS 651009-61-9

(2E)-1-(1H-Benzimidazol-1-yl)-3-(2-methoxyphenyl)prop-2-en-1-one

CAS 651009-61-9C₁₇H₁₄N₂O₂

(E)-1-(2-(Allylthio)-1H-benzo[d]imidazol-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one chemical structure, C19H15FN2OS, CAS 327094-34-8

(E)-1-(2-(Allylthio)-1H-benzo[d]imidazol-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one

CAS 327094-34-8C₁₉H₁₅FN₂OS

(E)-3-(3-Fluorophenyl)-1-(2-(methylthio)-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one chemical structure, C17H13FN2OS, CAS 612525-58-3

(E)-3-(3-Fluorophenyl)-1-(2-(methylthio)-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one

CAS 612525-58-3C₁₇H₁₃FN₂OS

(2Z)-3-Phenyl-1-(2-prop-2-ynylthiobenzimidazolyl)prop-2-en-1-one chemical structure, C19H14N2OS, CAS 1322282-41-6

(2Z)-3-Phenyl-1-(2-prop-2-ynylthiobenzimidazolyl)prop-2-en-1-one

CAS 1322282-41-6C₁₉H₁₄N₂OS

Ethyl [1-(3-phenylprop-2-enoyl)-1H-benzimidazol-2-yl]acetate chemical structure, C20H18N2O3, CAS 52335-21-4

Ethyl [1-(3-phenylprop-2-enoyl)-1H-benzimidazol-2-yl]acetate

CAS 52335-21-4C₂₀H₁₈N₂O₃