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Murcko scaffold

2-(Thiophen-2-yl)pyrimidin-4-ol scaffold

39 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
39
With full pages
4
Scaffold SMILES

O=c1ccnc(-c2cccs2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(Thiophen-2-yl)pyrimidin-4-ol page
Murcko scaffold O=c1ccnc(-c2cccs2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

Ethyl 6-oxo-2-thiophen-2-yl-1H-pyrimidine-5-carboxylate chemical structure, C11H10N2O3S, CAS 188937-37-3
Ethyl 6-oxo-2-thiophen-2-yl-1H-pyrimidine-5-carboxylate
CAS 188937-37-3C11H10N2O3S
2-(Thiophen-2-yl)pyrimidin-4-ol chemical structure, C8H6N2OS, CAS 125903-92-6
2-(Thiophen-2-yl)pyrimidin-4-ol
CAS 125903-92-6C8H6N2OS
6-Oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C9H6N2O3S, CAS 1247406-36-5
6-Oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-5-carboxylic acid
CAS 1247406-36-5C9H6N2O3S
2-(5-Bromothiophen-2-yl)-3,4-dihydropyrimidin-4-one chemical structure, C8H5BrN2OS, CAS 1155598-75-6
2-(5-Bromothiophen-2-yl)-3,4-dihydropyrimidin-4-one
CAS 1155598-75-6C8H5BrN2OS
2-(5-Chlorothiophen-2-yl)pyrimidin-4(3H)-one chemical structure, C8H5ClN2OS, CAS 1156236-07-5
2-(5-Chlorothiophen-2-yl)pyrimidin-4(3H)-one
CAS 1156236-07-5C8H5ClN2OS
2-(4-Bromothiophen-2-yl)pyrimidin-4(3H)-one chemical structure, C8H5BrN2OS, CAS 1156236-70-2
2-(4-Bromothiophen-2-yl)pyrimidin-4(3H)-one
CAS 1156236-70-2C8H5BrN2OS
5-Bromo-2-(thiophen-2-yl)pyrimidin-4-ol chemical structure, C8H5BrN2OS, CAS 1222529-48-7
5-Bromo-2-(thiophen-2-yl)pyrimidin-4-ol
CAS 1222529-48-7C8H5BrN2OS
5-Hydroxy-1-methyl-6-oxo-2-(2-thienyl)pyrimidine-4-carboxylic acid chemical structure, C10H8N2O4S, CAS 572916-85-9
5-Hydroxy-1-methyl-6-oxo-2-(2-thienyl)pyrimidine-4-carboxylic acid
CAS 572916-85-9C10H8N2O4S
5-Chloro-2-(thiophen-2-yl)pyrimidin-4-ol chemical structure, C8H5ClN2OS, CAS 1266480-34-5
5-Chloro-2-(thiophen-2-yl)pyrimidin-4-ol
CAS 1266480-34-5C8H5ClN2OS
2-(4-Bromothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C9H5BrN2O3S, CAS 1339881-83-2
2-(4-Bromothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
CAS 1339881-83-2C9H5BrN2O3S
2-(5-Bromothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C9H5BrN2O3S, CAS 1341857-42-8
2-(5-Bromothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
CAS 1341857-42-8C9H5BrN2O3S
2-(5-Chlorothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C9H5ClN2O3S, CAS 1895379-45-9
2-(5-Chlorothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
CAS 1895379-45-9C9H5ClN2O3S
2-(3-Methylthiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C10H8N2O3S, CAS 1889131-57-0
2-(3-Methylthiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
CAS 1889131-57-0C10H8N2O3S
6-Methyl-2-(thiophen-2-yl)pyrimidin-4-ol chemical structure, C9H8N2OS, CAS 13514-82-4
6-Methyl-2-(thiophen-2-yl)pyrimidin-4-ol
CAS 13514-82-4C9H8N2OS
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid chemical structure, C9H6N2O4S, CAS 391680-79-8
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid
CAS 391680-79-8C9H6N2O4S
5,6-Dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamide chemical structure, C9H7N3O3S, CAS 849475-71-4
5,6-Dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamide
CAS 849475-71-4C9H7N3O3S
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester chemical structure, C10H8N2O4S, CAS 391680-92-5
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester
CAS 391680-92-5C10H8N2O4S
Methyl 2-(3-aminothiophen-2-yl)-5-hydroxy-6-oxo-3,6-dihydropyrimidine-4-carboxylate chemical structure, C10H9N3O4S, CAS 391680-97-0
Methyl 2-(3-aminothiophen-2-yl)-5-hydroxy-6-oxo-3,6-dihydropyrimidine-4-carboxylate
CAS 391680-97-0C10H9N3O4S
5-Chloro-6-methyl-2-(2-thienyl)-4(3H)-pyrimidinone chemical structure, C9H7ClN2OS, CAS 286430-68-0
5-Chloro-6-methyl-2-(2-thienyl)-4(3H)-pyrimidinone
CAS 286430-68-0C9H7ClN2OS
2-(5-Chlorothiophen-2-yl)-5,6-dimethylpyrimidin-4(3H)-one chemical structure, C10H9ClN2OS, CAS 915084-67-2
2-(5-Chlorothiophen-2-yl)-5,6-dimethylpyrimidin-4(3H)-one
CAS 915084-67-2C10H9ClN2OS
2-(5-Bromothiophen-2-yl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one chemical structure, C10H9BrN2OS, CAS 1183638-92-7
2-(5-Bromothiophen-2-yl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one
CAS 1183638-92-7C10H9BrN2OS
5,6-Dimethyl-2-(thiophen-2-yl)-3,4-dihydropyrimidin-4-one chemical structure, C10H10N2OS, CAS 204394-29-6
5,6-Dimethyl-2-(thiophen-2-yl)-3,4-dihydropyrimidin-4-one
CAS 204394-29-6C10H10N2OS
2-(4-Bromothiophen-2-yl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one chemical structure, C10H9BrN2OS, CAS 1178495-85-6
2-(4-Bromothiophen-2-yl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one
CAS 1178495-85-6C10H9BrN2OS
5-Ethyl-6-methyl-2-(thiophen-2-yl)pyrimidin-4(3H)-one chemical structure, C11H12N2OS, CAS 915084-37-6
5-Ethyl-6-methyl-2-(thiophen-2-yl)pyrimidin-4(3H)-one
CAS 915084-37-6C11H12N2OS