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Murcko scaffold

Ring system with 5 rings and 23 atoms

308 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
23
Chemicals
308
With full pages
38
Scaffold SMILES

O=C1Cc2cc3n(c(=O)c2CO1)Cc1cc2ccccc2nc1-3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Cc2cc3n(c(=O)c2CO1)Cc1cc2ccccc2nc1-3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 308 chemicals

(±)-Camptothecin chemical structure, C20H16N2O4, CAS 31456-25-4
(±)-Camptothecin
CAS 31456-25-4C20H16N2O4
Camptothecin chemical structure, C20H16N2O4, CAS 7689-03-4
Camptothecin
CAS 7689-03-4C20H16N2O4
Topotecan hydrochloride chemical structure, C23H24ClN3O5, CAS 119413-54-6
Topotecan hydrochloride
CAS 119413-54-6C23H24ClN3O5
Topotecan chemical structure, C23H23N3O5, CAS 123948-87-8
Topotecan
CAS 123948-87-8C23H23N3O5
4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione chemical structure, C20H15N3O6, CAS 104195-61-1
4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS 104195-61-1C20H15N3O6
9-Aminocamptothecin chemical structure, C20H17N3O4, CAS 91421-43-1
9-Aminocamptothecin
CAS 91421-43-1C20H17N3O4
Hydroxycamptothecin chemical structure, C20H16N2O5, CAS 19685-09-7
Hydroxycamptothecin
CAS 19685-09-7C20H16N2O5
10-Methoxycamptothecin chemical structure, C21H18N2O5, CAS 19685-10-0
10-Methoxycamptothecin
CAS 19685-10-0C21H18N2O5
(S)-4-Chloro-4-ethyl-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione chemical structure, C20H15ClN2O3, CAS 7691-05-6
(S)-4-Chloro-4-ethyl-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
CAS 7691-05-6C20H15ClN2O3
7-Ethyl-10-hydroxycamptothecin chemical structure, C22H20N2O5, CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin
CAS 86639-52-3C22H20N2O5
10-Aminocamptothecin chemical structure, C20H17N3O4, CAS 86639-63-6
10-Aminocamptothecin
CAS 86639-63-6C20H17N3O4
10-Bromoacetamidomethylcamptothecin chemical structure, C23H20BrN3O5, CAS 131206-45-6
10-Bromoacetamidomethylcamptothecin
CAS 131206-45-6C23H20BrN3O5
9-Methoxycamptothecin chemical structure, C21H18N2O5, CAS 39026-92-1
9-Methoxycamptothecin
CAS 39026-92-1C21H18N2O5
7-Ethyl-10-hydroxy-20-deoxyaminocamptothecin chemical structure, C22H21N3O4, CAS 126266-01-1
7-Ethyl-10-hydroxy-20-deoxyaminocamptothecin
CAS 126266-01-1C22H21N3O4
7-Ethylcamptothecin chemical structure, C22H20N2O4, CAS 78287-27-1
7-Ethylcamptothecin
CAS 78287-27-1C22H20N2O4
7-Ethyl-10-methoxy-20-deoxyaminocamptothecin chemical structure, C23H23N3O4, CAS 126266-02-2
7-Ethyl-10-methoxy-20-deoxyaminocamptothecin
CAS 126266-02-2C23H23N3O4
9-Amino-20-camptothecin chemical structure, C20H17N3O4, CAS 130194-90-0
9-Amino-20-camptothecin
CAS 130194-90-0C20H17N3O4
Cositecan chemical structure, C25H28N2O4Si, CAS 203923-89-1
Cositecan
CAS 203923-89-1C25H28N2O4Si
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-(hydroxymethyl)-, (S)- chemical structure, C21H18N2O5, CAS 78287-14-6
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-(hydroxymethyl)-, (S)-
CAS 78287-14-6C21H18N2O5
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxylic acid, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, (S)- chemical structure, C21H16N2O6, CAS 78287-24-8
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxylic acid, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, (S)-
CAS 78287-24-8C21H16N2O6
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-propyl-, (S)- chemical structure, C23H22N2O4, CAS 78287-28-2
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-propyl-, (S)-
CAS 78287-28-2C23H22N2O4
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, (S)- chemical structure, C21H16N2O5, CAS 80758-83-4
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, (S)-
CAS 80758-83-4C21H16N2O5
Methyl (S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-hexanoate chemical structure, C27H28N2O6, CAS 89808-79-7
Methyl (S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-hexanoate
CAS 89808-79-7C27H28N2O6
12-(Acetyloxy)-4-ethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione chemical structure, C22H18N2O6, CAS 74418-04-5
12-(Acetyloxy)-4-ethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
CAS 74418-04-5C22H18N2O6