Murcko scaffold
2-Cyclobutylpiperidine scaffold
86 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 86
- With full pages
- 3
Scaffold SMILES
C1CCC(C2CCC2)NC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 86 chemicals
2-Cyclobutylpiperidine
CAS 526183-12-0C9H17N
2-Cyclobutylpiperidine oxalate
CAS 1177331-83-7C11H19NO4
![tert-Butyl 2-[1-(aminomethyl)cyclobutyl]piperidine-1-carboxylate chemical structure, C15H28N2O2, CAS 1369139-00-3](/s/QRUCSMXSGSKLIT-UHFFFAOYSA-N.svg)
tert-Butyl 2-[1-(aminomethyl)cyclobutyl]piperidine-1-carboxylate
CAS 1369139-00-3C15H28N2O2
1-(1-Methylpiperidin-2-yl)cyclobutan-1-amine
CAS 1557887-64-5C10H20N2
![1-[1-(1-Methylpiperidin-2-yl)cyclobutyl]methanamine chemical structure, C11H22N2, CAS 1554831-55-8](/s/PNXZNPCWAOVXMR-UHFFFAOYSA-N.svg)
1-[1-(1-Methylpiperidin-2-yl)cyclobutyl]methanamine
CAS 1554831-55-8C11H22N2
1-(Piperidin-2-yl)cyclobutane-1-carboxylic acid
CAS 1550790-73-2C10H17NO2
Methyl 1-(piperidin-2-yl)cyclobutane-1-carboxylate
CAS 1546562-44-0C11H19NO2
1-(1-Methylpiperidin-2-yl)cyclobutane-1-carboxylic acid
CAS 1545804-95-2C11H19NO2
tert-Butyl 2-(1-aminocyclobutyl)piperidine-1-carboxylate
CAS 1784370-68-8C14H26N2O2
6-Cyclobutylpiperidine-3-carboxylic acid
CAS 1554988-73-6C10H17NO2
Methyl 6-cyclobutylpiperidine-3-carboxylate
CAS 1547055-52-6C11H19NO2
Methyl 2-cyclobutyl-1-methylpiperidine-4-carboxylate
CAS 1782479-44-0C12H21NO2
2-Cyclobutylpiperidine hydrochloride
CAS 1889294-03-4C9H18ClN
2-Cyclobutyl-3,3-difluoropiperidine hydrochloride
CAS 1888792-97-9C9H16ClF2N
![tert-Butyl N-[1-(piperidin-2-yl)cyclobutyl]carbamate chemical structure, C14H26N2O2, CAS 1888777-10-3](/s/IFGFLJCJENSCOF-UHFFFAOYSA-N.svg)
tert-Butyl N-[1-(piperidin-2-yl)cyclobutyl]carbamate
CAS 1888777-10-3C14H26N2O2
![tert-Butyl N-{[1-(piperidin-2-yl)cyclobutyl]methyl}carbamate chemical structure, C15H28N2O2, CAS 2126161-42-8](/s/FUALPSYUAJYWHH-UHFFFAOYSA-N.svg)
tert-Butyl N-{[1-(piperidin-2-yl)cyclobutyl]methyl}carbamate
CAS 2126161-42-8C15H28N2O2
![rac-(3R,6S)-1-[(tert-Butoxy)carbonyl]-6-cyclobutylpiperidine-3-carboxylic acid chemical structure, C15H25NO4, CAS 2219369-44-3](/s/ODAJERWGGIOSPD-NEPJUHHUSA-N.svg)
rac-(3R,6S)-1-[(tert-Butoxy)carbonyl]-6-cyclobutylpiperidine-3-carboxylic acid
CAS 2219369-44-3C15H25NO4
1-(Piperidin-2-yl)cyclobutan-1-ol hcl
CAS 2089648-73-5C9H18ClNO
![1-[(tert-Butoxy)carbonyl]-6-cyclobutylpiperidine-3-carboxylic acid chemical structure, C15H25NO4, CAS 2219369-69-2](/s/ODAJERWGGIOSPD-UHFFFAOYSA-N.svg)
1-[(tert-Butoxy)carbonyl]-6-cyclobutylpiperidine-3-carboxylic acid
CAS 2219369-69-2C15H25NO4
![2-[1-(Trifluoromethyl)cyclobutyl]piperidine hydrochloride chemical structure, C10H17ClF3N, CAS 2445792-54-9](/s/QYCVRNJSMAQVJT-UHFFFAOYSA-N.svg)
2-[1-(Trifluoromethyl)cyclobutyl]piperidine hydrochloride
CAS 2445792-54-9C10H17ClF3N
![2-[1-(Trifluoromethyl)cyclobutyl]piperidine chemical structure, C10H16F3N, CAS 2445790-64-5](/s/FEWQBXFTVBJYEJ-UHFFFAOYSA-N.svg)
2-[1-(Trifluoromethyl)cyclobutyl]piperidine
CAS 2445790-64-5C10H16F3N
Methyl 1-(piperidin-2-yl)cyclobutane-1-carboxylate hydrochloride
CAS 2460749-49-7C11H20ClNO2
![1-{1-[(tert-Butoxy)carbonyl]piperidin-2-yl}cyclobutane-1-carboxylic acid chemical structure, C15H25NO4, CAS 2229174-20-1](/s/BPDYUQBRUCSXHV-UHFFFAOYSA-N.svg)
1-{1-[(tert-Butoxy)carbonyl]piperidin-2-yl}cyclobutane-1-carboxylic acid
CAS 2229174-20-1C15H25NO4
1-(1-(tert-Butoxycarbonyl)piperidin-2-yl)-3,3-difluorocyclobutane-1-carboxylic acid
CAS 2172496-20-5C15H23F2NO4
- rel-tert-Butyl ((1r,3r)-3-(5-methylpiperidin-2-yl)cyclobutyl)carbamate2760568-58-7C15H28N2O2
- rel-Methyl 2-(2-((1r,3r)-3-((tert-butoxycarbonyl)amino)cyclobutyl)-5-methylpiperidin-1-yl)-2-oxoacetate2760568-59-8C18H30N2O5
- 1-{1-[(2,2-Dimethylpropoxy)carbonyl]piperidin-2-yl}-3,3-difluorocyclobutane-1-carboxylic acid2172031-35-3C16H25F2NO4
- tert-Butyl 2-formyl-2-(2-hydroxycyclobutyl)piperidine-1-carboxylate2161789-51-9C15H25NO4
- 2-(Piperidin-2-yl)cyclobutan-1-ol2172571-77-4C9H17NO
- tert-Butyl 2-[1-(2-aminoethyl)cyclobutyl]piperidine-1-carboxylate2228498-29-9C16H30N2O2
- tert-Butyl 2-[1-(aminomethyl)-3-hydroxycyclobutyl]piperidine-1-carboxylate2228932-36-1C15H28N2O3
- tert-Butyl 2-[1-(hydroxymethyl)cyclobutyl]piperidine-1-carboxylate2229479-84-7C15H27NO3
- tert-Butyl 2-[1-(aminomethyl)-3,3-difluorocyclobutyl]piperidine-1-carboxylate2228814-49-9C15H26F2N2O2
- 3-Hydroxy-1-(1-methylpiperidin-2-yl)cyclobutane-1-carboxylic acid2228597-42-8C11H19NO3
- 3-Amino-3-(1-methylpiperidin-2-yl)cyclobutan-1-ol2228086-78-8C10H20N2O
- tert-Butyl 2-[1-(aminomethyl)cyclobutyl]-5,5-dimethylpiperidine-1-carboxylate2228572-09-4C17H32N2O2
- 2-[1-(1-Methylpiperidin-2-yl)cyclobutyl]ethan-1-amine2228443-59-0C12H24N2
- tert-Butyl 2-[1-(hydroxymethyl)cyclobutyl]-5,5-dimethylpiperidine-1-carboxylate2228201-42-9C17H31NO3
- tert-Butyl 2-(1-amino-3-hydroxycyclobutyl)-5,5-dimethylpiperidine-1-carboxylate2228126-02-9C16H30N2O3
- tert-Butyl 2-[1-(aminomethyl)-3,3-difluorocyclobutyl]-5,5-dimethylpiperidine-1-carboxylate2228950-47-6C17H30F2N2O2
- tert-Butyl 2-(1-cyanocyclobutyl)piperidine-1-carboxylate2229128-55-4C15H24N2O2
- 1-{1-[(tert-Butoxy)carbonyl]-5,5-dimethylpiperidin-2-yl}-3-hydroxycyclobutane-1-carboxylic acid2228274-38-0C17H29NO5
- 3-Amino-1-{1-[(tert-butoxy)carbonyl]piperidin-2-yl}cyclobutane-1-carboxylic acid2228705-66-4C15H26N2O4
- 1-{1-[(tert-Butoxy)carbonyl]-5,5-dimethylpiperidin-2-yl}cyclobutane-1-carboxylic acid2228641-79-8C17H29NO4
- 1-{1-[(tert-Butoxy)carbonyl]piperidin-2-yl}-3-hydroxycyclobutane-1-carboxylic acid2228491-34-5C15H25NO5
- 3,3-Difluoro-1-(1-methylpiperidin-2-yl)cyclobutan-1-amine2228967-91-5C10H18F2N2
- tert-Butyl 2-[1-(aminomethyl)-3-hydroxycyclobutyl]-5,5-dimethylpiperidine-1-carboxylate2229238-25-7C17H32N2O3
- Methyl 6-[1-(trifluoromethyl)cyclobutyl]piperidine-3-carboxylate2743432-12-2C12H18F3NO2
Related scaffolds
Same ring framework with different atoms or bond orders
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O=C1CC(c2ccccc2)C145 chemicals
c1ccc(C2CCC2)nc137 chemicals
O=C1CCN1c1ccccc132 chemicals
c1ccc(C2CCN2)cc128 chemicals
c1ccc(C2CCO2)cc123 chemicals
c1ccc(N2CCC2)cc122 chemicals
c1ccc(N2CCC2)nc118 chemicals
c1cncc(C2CCC2)c116 chemicals
C1CC(C2CCNCC2)C116 chemicals