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Murcko scaffold

Ring system with 2 rings and 18 atoms

153 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
153
With full pages
36
Scaffold SMILES

O=C(CSc1nc(=O)cc[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nc(=O)cc[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 153 chemicals

2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide chemical structure, C16H18N4O2S, CAS 694473-32-0
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide
CAS 694473-32-0C16H18N4O2S
2-[(4-Hydroxypyrimidin-2-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide chemical structure, C13H13N3O3S, CAS 380321-09-5
2-[(4-Hydroxypyrimidin-2-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide
CAS 380321-09-5C13H13N3O3S
N-(3-Chloro-2-methylphenyl)-2-[(4-hydroxypyrimidin-2-yl)sulfanyl]acetamide chemical structure, C13H12ClN3O2S, CAS 385400-45-3
N-(3-Chloro-2-methylphenyl)-2-[(4-hydroxypyrimidin-2-yl)sulfanyl]acetamide
CAS 385400-45-3C13H12ClN3O2S
N-(3-Chloro-4-fluorophenyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C12H9ClFN3O2S, CAS 457609-45-9
N-(3-Chloro-4-fluorophenyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 457609-45-9C12H9ClFN3O2S
Methyl 2-[[2-(6-amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanylacetyl]amino]benzoate chemical structure, C17H18N4O4S, CAS 694461-02-4
Methyl 2-[[2-(6-amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanylacetyl]amino]benzoate
CAS 694461-02-4C17H18N4O4S
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-chlorophenyl)acetamide chemical structure, C15H15ClN4O2S, CAS 694456-79-6
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-chlorophenyl)acetamide
CAS 694456-79-6C15H15ClN4O2S
4-[2-(1-Allyl-6-amino-4-oxo-1,4-dihydro-pyrimidin-2-ylsulfanyl)-acetylamino]-benzoic acid ethyl ester chemical structure, C18H20N4O4S, CAS 694460-08-7
4-[2-(1-Allyl-6-amino-4-oxo-1,4-dihydro-pyrimidin-2-ylsulfanyl)-acetylamino]-benzoic acid ethyl ester
CAS 694460-08-7C18H20N4O4S
Methyl 4-[({[6-amino-4-oxo-1-(prop-2-en-1-yl)-1,4-dihydropyrimidin-2-yl]sulfanyl}acetyl)amino]benzoate chemical structure, C17H18N4O4S, CAS 765903-12-6
Methyl 4-[({[6-amino-4-oxo-1-(prop-2-en-1-yl)-1,4-dihydropyrimidin-2-yl]sulfanyl}acetyl)amino]benzoate
CAS 765903-12-6C17H18N4O4S
N-(4-Acetylphenyl)-2-(6-amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanylacetamide chemical structure, C17H18N4O3S, CAS 831206-48-5
N-(4-Acetylphenyl)-2-(6-amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanylacetamide
CAS 831206-48-5C17H18N4O3S
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-chlorophenyl)propanamide chemical structure, C16H17ClN4O2S, CAS 713096-75-4
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-chlorophenyl)propanamide
CAS 713096-75-4C16H17ClN4O2S
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(3-chlorophenyl)propanamide chemical structure, C16H17ClN4O2S, CAS 706776-60-5
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(3-chlorophenyl)propanamide
CAS 706776-60-5C16H17ClN4O2S
Ethyl 4-[(2-{[6-amino-4-oxo-1-(prop-2-en-1-yl)-1,4-dihydropyrimidin-2-yl]sulfanyl}propanoyl)amino]benzoate chemical structure, C19H22N4O4S, CAS 709004-42-2
Ethyl 4-[(2-{[6-amino-4-oxo-1-(prop-2-en-1-yl)-1,4-dihydropyrimidin-2-yl]sulfanyl}propanoyl)amino]benzoate
CAS 709004-42-2C19H22N4O4S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(4-hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C13H9ClF3N3O3S, CAS 333420-89-6
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(4-hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 333420-89-6C13H9ClF3N3O3S
N-(4-Cyanophenyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C13H10N4O2S, CAS 5512-76-5
N-(4-Cyanophenyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 5512-76-5C13H10N4O2S
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-sulfamoylphenyl)butanamide chemical structure, C17H21N5O4S2, CAS 512807-78-2
2-(6-Amino-4-oxo-1-prop-2-enylpyrimidin-2-yl)sulfanyl-N-(4-sulfamoylphenyl)butanamide
CAS 512807-78-2C17H21N5O4S2
2-[[2-[(1,6-Dihydro-6-oxo-2-pyrimidinyl)thio]acetyl]amino]benzamide chemical structure, C13H12N4O3S, CAS 777876-91-2
2-[[2-[(1,6-Dihydro-6-oxo-2-pyrimidinyl)thio]acetyl]amino]benzamide
CAS 777876-91-2C13H12N4O3S
N-(2,4-Dichlorophenyl)-2-(4,6-dihydroxypyrimidin-2-ylthio)acetamide chemical structure, C12H9Cl2N3O3S, CAS 895900-55-7
N-(2,4-Dichlorophenyl)-2-(4,6-dihydroxypyrimidin-2-ylthio)acetamide
CAS 895900-55-7C12H9Cl2N3O3S
2-(4,6-Dihydroxypyrimidin-2-ylthio)-N-(5-chloro-2-methylphenyl)acetamide chemical structure, C13H12ClN3O3S, CAS 904475-95-2
2-(4,6-Dihydroxypyrimidin-2-ylthio)-N-(5-chloro-2-methylphenyl)acetamide
CAS 904475-95-2C13H12ClN3O3S
N-(2-Ethoxyphenyl)-2-(4-hydroxy-6-propylpyrimidin-2-ylthio)acetamide chemical structure, C17H21N3O3S, CAS 356775-49-0
N-(2-Ethoxyphenyl)-2-(4-hydroxy-6-propylpyrimidin-2-ylthio)acetamide
CAS 356775-49-0C17H21N3O3S
N-(2,4-Dimethylphenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetamide chemical structure, C15H17N3O2S, CAS 325994-27-2
N-(2,4-Dimethylphenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetamide
CAS 325994-27-2C15H17N3O2S
2-[(5-Ethyl-6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-phenylacetamide chemical structure, C15H17N3O2S, CAS 28994-65-2
2-[(5-Ethyl-6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-phenylacetamide
CAS 28994-65-2C15H17N3O2S
2-[(6-Amino-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(3-chlorophenyl)propanamide chemical structure, C13H13ClN4O2S, CAS 708235-96-5
2-[(6-Amino-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(3-chlorophenyl)propanamide
CAS 708235-96-5C13H13ClN4O2S
2-(4-Amino-6-hydroxy-pyrimidin-2-ylsulfanyl)-N-(4-methoxy-phenyl)-acetamide chemical structure, C13H14N4O3S, CAS 36162-32-0
2-(4-Amino-6-hydroxy-pyrimidin-2-ylsulfanyl)-N-(4-methoxy-phenyl)-acetamide
CAS 36162-32-0C13H14N4O3S
N-(4-Bromo-2-fluorophenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C13H11BrFN3O2S, CAS 386763-13-9
N-(4-Bromo-2-fluorophenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetamide
CAS 386763-13-9C13H11BrFN3O2S