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Murcko scaffold

RefChem:382092 scaffold

43 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
43
With full pages
14
Scaffold SMILES

O=C(CSc1ncn[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RefChem:382092 page
Murcko scaffold O=C(CSc1ncn[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 43 of 43 chemicals

RefChem:382092 chemical structure, C10H9N3OS, CAS 32189-00-7
RefChem:382092
CAS 32189-00-7C10H9N3OS
1-(4-Bromophenyl)-2-(1H-1,2,4-triazol-5-ylthio)ethanone chemical structure, C10H8BrN3OS, CAS 37664-32-7
1-(4-Bromophenyl)-2-(1H-1,2,4-triazol-5-ylthio)ethanone
CAS 37664-32-7C10H8BrN3OS
2-(5-Methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-1-phenyl-ethanone chemical structure, C11H11N3OS, CAS 5906-74-1
2-(5-Methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-1-phenyl-ethanone
CAS 5906-74-1C11H11N3OS
1-(4-Chlorophenyl)-2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-ethanone chemical structure, C11H10ClN3OS, CAS 301193-48-6
1-(4-Chlorophenyl)-2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-ethanone
CAS 301193-48-6C11H10ClN3OS
1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-3-ylsulfanyl)-1-ethanone chemical structure, C10H8ClN3OS, CAS 37664-31-6
1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-3-ylsulfanyl)-1-ethanone
CAS 37664-31-6C10H8ClN3OS
1-(4-Methoxyphenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanone chemical structure, C11H11N3O2S, CAS 332169-82-1
1-(4-Methoxyphenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanone
CAS 332169-82-1C11H11N3O2S
1-(4-Chlorophenyl)-2-((5-methyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one chemical structure, C11H10ClN3OS, CAS 37664-34-9
1-(4-Chlorophenyl)-2-((5-methyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one
CAS 37664-34-9C11H10ClN3OS
1-(4-Isopropylphenyl)-2-(4H-1,2,4-triazol-3-ylthio)ethanone chemical structure, C13H15N3OS, CAS 459420-13-4
1-(4-Isopropylphenyl)-2-(4H-1,2,4-triazol-3-ylthio)ethanone
CAS 459420-13-4C13H15N3OS
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-chlorophenyl)ethanone chemical structure, C10H9ClN4OS, CAS 261761-11-9
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-chlorophenyl)ethanone
CAS 261761-11-9C10H9ClN4OS
2-[(5-Amino-4H-1,2,4-triazol-3-yl)sulfanyl]-1-(2,4-dichlorophenyl)ethanone chemical structure, C10H8Cl2N4OS, CAS 634162-93-9
2-[(5-Amino-4H-1,2,4-triazol-3-yl)sulfanyl]-1-(2,4-dichlorophenyl)ethanone
CAS 634162-93-9C10H8Cl2N4OS
1-(4-Chlorophenyl)-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone chemical structure, C12H12ClN3OS, CAS 67944-07-4
1-(4-Chlorophenyl)-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
CAS 67944-07-4C12H12ClN3OS
2-[(5-Methyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-propan-2-ylphenyl)ethanone chemical structure, C14H17N3OS, CAS 429639-14-5
2-[(5-Methyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-propan-2-ylphenyl)ethanone
CAS 429639-14-5C14H17N3OS
2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethan-1-one chemical structure, C11H11N3OS, CAS 5374-08-3
2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethan-1-one
CAS 5374-08-3C11H11N3OS
1-(4-Bromophenyl)-2-[(5-methyl-4H-1,2,4-triazol-3-yl)thio]ethanone chemical structure, C11H10BrN3OS, CAS 6196-97-0
1-(4-Bromophenyl)-2-[(5-methyl-4H-1,2,4-triazol-3-yl)thio]ethanone
CAS 6196-97-0C11H10BrN3OS
2-((5-Amino-1H-1,2,4-triazol-3-yl)thio)-1-(4-bromophenyl)ethanone chemical structure, C10H9BrN4OS, CAS 326003-66-1
2-((5-Amino-1H-1,2,4-triazol-3-yl)thio)-1-(4-bromophenyl)ethanone
CAS 326003-66-1C10H9BrN4OS
1-(4-Ethylphenyl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one chemical structure, C13H15N3OS, CAS 312278-33-4
1-(4-Ethylphenyl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one
CAS 312278-33-4C13H15N3OS
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-nitrophenyl)ethanone chemical structure, C11H10N4O3S, CAS 725224-60-2
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-nitrophenyl)ethanone
CAS 725224-60-2C11H10N4O3S
N-[4-[2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]phenyl]acetamide chemical structure, C13H14N4O2S, CAS 825596-45-0
N-[4-[2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]phenyl]acetamide
CAS 825596-45-0C13H14N4O2S
2-{[4-Allyl-5-(methoxymethyl)-4H-1,2,4-triazol-3-yl]thio}-1-(4-fluorophenyl)ethanone chemical structure, C15H16FN3O2S, CAS 712324-61-3
2-{[4-Allyl-5-(methoxymethyl)-4H-1,2,4-triazol-3-yl]thio}-1-(4-fluorophenyl)ethanone
CAS 712324-61-3C15H16FN3O2S
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylphenyl)ethanone chemical structure, C11H12N4OS, CAS 669056-12-6
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylphenyl)ethanone
CAS 669056-12-6C11H12N4OS
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-nitrophenyl)ethanone chemical structure, C10H9N5O3S, CAS 634162-95-1
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-nitrophenyl)ethanone
CAS 634162-95-1C10H9N5O3S
2-((4H-1,2,4-Triazol-3-yl)thio)-1-(2,4,5-trimethylphenyl)ethan-1-one chemical structure, C13H15N3OS, CAS 851110-77-5
2-((4H-1,2,4-Triazol-3-yl)thio)-1-(2,4,5-trimethylphenyl)ethan-1-one
CAS 851110-77-5C13H15N3OS
1-(4-tert-Butylphenyl)-2-(1H-1,2,4-triazol-3-ylthio)ethanone chemical structure, C14H17N3OS, CAS 690646-96-9
1-(4-tert-Butylphenyl)-2-(1H-1,2,4-triazol-3-ylthio)ethanone
CAS 690646-96-9C14H17N3OS
2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylphenyl)ethan-1-one chemical structure, C12H13N3OS, CAS 309266-24-8
2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylphenyl)ethan-1-one
CAS 309266-24-8C12H13N3OS