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Murcko scaffold

5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)pyrazine scaffold

219 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
219
With full pages
29
Scaffold SMILES

c1nnc2n1CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)pyrazine page
Murcko scaffold c1nnc2n1CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 219 chemicals

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine chemical structure, C6H7F3N4, CAS 486460-21-3
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine
CAS 486460-21-3C6H7F3N4
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride chemical structure, C6H8ClF3N4, CAS 762240-92-6
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS 762240-92-6C6H8ClF3N4
5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride chemical structure, C5H9ClN4, CAS 837430-14-5
5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS 837430-14-5C5H9ClN4
5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)pyrazine chemical structure, C5H8N4, CAS 345311-09-3
5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)pyrazine
CAS 345311-09-3C5H8N4
3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C5H7BrN4, CAS 903130-08-5
3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 903130-08-5C5H7BrN4
tert-Butyl 3-bromo-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine-7-carboxylate chemical structure, C10H15BrN4O2, CAS 723286-80-4
tert-Butyl 3-bromo-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine-7-carboxylate
CAS 723286-80-4C10H15BrN4O2
3-Methoxy-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C6H10N4O, CAS 723286-82-6
3-Methoxy-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 723286-82-6C6H10N4O
Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxylate chemical structure, C8H12N4O2, CAS 723286-68-8
Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxylate
CAS 723286-68-8C8H12N4O2
5-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C7H9F3N4, CAS 723286-87-1
5-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 723286-87-1C7H9F3N4
7-(tert-Butoxycarbonyl)-5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine chemical structure, C12H17F3N4O2, CAS 723286-89-3
7-(tert-Butoxycarbonyl)-5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
CAS 723286-89-3C12H17F3N4O2
5,8-Dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C8H11F3N4, CAS 780754-27-0
5,8-Dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 780754-27-0C8H11F3N4
5,5-Dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C8H11F3N4, CAS 723286-97-3
5,5-Dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 723286-97-3C8H11F3N4
tert-Butyl 3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-A]pyrazine-7(8H)-carboxylate chemical structure, C11H15F3N4O2, CAS 877402-43-2
tert-Butyl 3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-A]pyrazine-7(8H)-carboxylate
CAS 877402-43-2C11H15F3N4O2
8-Ethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride chemical structure, C8H12ClF3N4, CAS 2089649-88-5
8-Ethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS 2089649-88-5C8H12ClF3N4
8-Ethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C8H11F3N4, CAS 1092351-58-0
8-Ethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1092351-58-0C8H11F3N4
7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid chemical structure, C11H16N4O4, CAS 1053656-19-1
7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid
CAS 1053656-19-1C11H16N4O4
3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride chemical structure, C5H8BrClN4, CAS 1172057-73-6
3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS 1172057-73-6C5H8BrClN4
tert-Butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-A]pyrazine-7(8H)-carboxylate chemical structure, C11H18N4O3, CAS 723286-81-5
tert-Butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-A]pyrazine-7(8H)-carboxylate
CAS 723286-81-5C11H18N4O3
3-Ethyl-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine chemical structure, C7H12N4, CAS 791777-96-3
3-Ethyl-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine
CAS 791777-96-3C7H12N4
3-(Trifluoromethyl)-7-methyl-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine chemical structure, C7H9F3N4, CAS 794479-17-7
3-(Trifluoromethyl)-7-methyl-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
CAS 794479-17-7C7H9F3N4
3-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid chemical structure, C7H10N4O2, CAS 144888-67-5
3-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid
CAS 144888-67-5C7H10N4O2
(5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)methanol chemical structure, C6H10N4O, CAS 945262-31-7
(5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)methanol
CAS 945262-31-7C6H10N4O
tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate chemical structure, C10H16N4O2, CAS 723286-79-1
tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
CAS 723286-79-1C10H16N4O2
Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate hydrochloride chemical structure, C8H13ClN4O2, CAS 1187830-58-5
Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate hydrochloride
CAS 1187830-58-5C8H13ClN4O2