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Murcko scaffold

1-(1H-Indol-3-yl)-2-(piperazin-1-yl)ethane-1,2-dione scaffold

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
9
With full pages
3
Scaffold SMILES

O=C(C(=O)N1CCNCC1)c1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1H-Indol-3-yl)-2-(piperazin-1-yl)ethane-1,2-dione page
Murcko scaffold O=C(C(=O)N1CCNCC1)c1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

4-[2-(1H-Indol-3-yl)-2-oxoacetyl]piperazine-1-carbaldehyde chemical structure, C15H15N3O3, CAS 497060-92-1
4-[2-(1H-Indol-3-yl)-2-oxoacetyl]piperazine-1-carbaldehyde
CAS 497060-92-1C15H15N3O3
Ethyl 4-[2-(1H-indol-3-yl)-2-oxoacetyl]piperazine-1-carboxylate chemical structure, C17H19N3O4, CAS 497060-87-4
Ethyl 4-[2-(1H-indol-3-yl)-2-oxoacetyl]piperazine-1-carboxylate
CAS 497060-87-4C17H19N3O4
1-(1,2-Dimethyl-1H-indol-3-yl)-2-(4-ethylpiperazin-1-yl)ethane-1,2-dione chemical structure, C18H23N3O2, CAS 862814-11-7
1-(1,2-Dimethyl-1H-indol-3-yl)-2-(4-ethylpiperazin-1-yl)ethane-1,2-dione
CAS 862814-11-7C18H23N3O2
Ethyl 4-(2-(1,2-dimethyl-1H-indol-3-yl)-2-oxoacetyl)piperazine-1-carboxylate chemical structure, C19H23N3O4, CAS 862814-14-0
Ethyl 4-(2-(1,2-dimethyl-1H-indol-3-yl)-2-oxoacetyl)piperazine-1-carboxylate
CAS 862814-14-0C19H23N3O4
1-(2-Methyl-1H-indol-3-yl)-2-(4-methylpiperazin-1-yl)ethane-1,2-dione chemical structure, C16H19N3O2, CAS 170884-64-7
1-(2-Methyl-1H-indol-3-yl)-2-(4-methylpiperazin-1-yl)ethane-1,2-dione
CAS 170884-64-7C16H19N3O2
Ethyl 4-[2-(2-methyl-1H-indol-3-yl)-2-oxoacetyl]piperazine-1-carboxylate chemical structure, C18H21N3O4, CAS 852368-54-8
Ethyl 4-[2-(2-methyl-1H-indol-3-yl)-2-oxoacetyl]piperazine-1-carboxylate
CAS 852368-54-8C18H21N3O4
N,N-Diethyl-2-[3-[2-(4-methylpiperazin-1-yl)-2-oxoacetyl]indol-1-yl]acetamide chemical structure, C21H28N4O3, CAS 893999-96-7
N,N-Diethyl-2-[3-[2-(4-methylpiperazin-1-yl)-2-oxoacetyl]indol-1-yl]acetamide
CAS 893999-96-7C21H28N4O3
N,N-Diethyl-2-[3-[2-(4-ethylpiperazin-1-yl)-2-oxoacetyl]indol-1-yl]acetamide chemical structure, C22H30N4O3, CAS 894000-02-3
N,N-Diethyl-2-[3-[2-(4-ethylpiperazin-1-yl)-2-oxoacetyl]indol-1-yl]acetamide
CAS 894000-02-3C22H30N4O3
1-(1H-Indol-3-yl)-2-(piperazin-1-yl)ethane-1,2-dione chemical structure, C14H15N3O2, CAS 313337-36-9
1-(1H-Indol-3-yl)-2-(piperazin-1-yl)ethane-1,2-dione
CAS 313337-36-9C14H15N3O2