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Murcko scaffold

1-(5-Isoquinolinylsulfonyl)piperazine scaffold

21 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
21
With full pages
6
Scaffold SMILES

O=S(=O)(c1cccc2cnccc12)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(5-Isoquinolinylsulfonyl)piperazine page
Murcko scaffold O=S(=O)(c1cccc2cnccc12)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

iso-H 7 chemical structure, C14H17N3O2S, CAS 84477-73-6
iso-H 7
CAS 84477-73-6C14H17N3O2S
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine chemical structure, C14H17N3O2S, CAS 84477-87-2
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
CAS 84477-87-2C14H17N3O2S
1-(5-Isoquinolinylsulfonyl)piperazine chemical structure, C13H15N3O2S, CAS 84468-24-6
1-(5-Isoquinolinylsulfonyl)piperazine
CAS 84468-24-6C13H15N3O2S
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride chemical structure, C14H19Cl2N3O2S, CAS 108930-17-2
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride
CAS 108930-17-2C14H19Cl2N3O2S
Isoquinoline, 5-((3-methyl-1-piperazinyl)sulfonyl)-, hydrochloride (1:1) chemical structure, C14H18ClN3O2S, CAS 141543-65-9
Isoquinoline, 5-((3-methyl-1-piperazinyl)sulfonyl)-, hydrochloride (1:1)
CAS 141543-65-9C14H18ClN3O2S
8-Chloro-5-piperazin-1-ylsulfonylisoquinoline chemical structure, C13H14ClN3O2S, CAS 110408-12-3
8-Chloro-5-piperazin-1-ylsulfonylisoquinoline
CAS 110408-12-3C13H14ClN3O2S
5-(Piperazine-1-sulfonyl)isoquinoline--hydrogen chloride (1/1) chemical structure, C13H16ClN3O2S, CAS 141543-63-7
5-(Piperazine-1-sulfonyl)isoquinoline--hydrogen chloride (1/1)
CAS 141543-63-7C13H16ClN3O2S
1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine dihydrochloride chemical structure, C14H19Cl2N3O2S, CAS 140663-38-3
1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine dihydrochloride
CAS 140663-38-3C14H19Cl2N3O2S
Piperazine, 1-(5-isoquinolinylsulfonyl)-4-methyl- chemical structure, C14H17N3O2S, CAS 141543-82-0
Piperazine, 1-(5-isoquinolinylsulfonyl)-4-methyl-
CAS 141543-82-0C14H17N3O2S
5-(Piperazine-1-sulfonyl)isoquinoline dihydrochloride chemical structure, C13H17Cl2N3O2S, CAS 210297-47-5
5-(Piperazine-1-sulfonyl)isoquinoline dihydrochloride
CAS 210297-47-5C13H17Cl2N3O2S
1-(5-Isoquinolinesulfonyl)-2,5-dimethylpiperazine chemical structure, C15H19N3O2S, CAS 84478-16-0
1-(5-Isoquinolinesulfonyl)-2,5-dimethylpiperazine
CAS 84478-16-0C15H19N3O2S
4-(Isoquinoline-5-sulfonyl)piperazine-1-carboximidamide chemical structure, C14H17N5O2S, CAS 92564-57-3
4-(Isoquinoline-5-sulfonyl)piperazine-1-carboximidamide
CAS 92564-57-3C14H17N5O2S
5-(3,5-Dimethylpiperazine-1-sulfonyl)isoquinoline chemical structure, C15H19N3O2S, CAS 84477-74-7
5-(3,5-Dimethylpiperazine-1-sulfonyl)isoquinoline
CAS 84477-74-7C15H19N3O2S
1-(8-Chloro-5-isoquinolinesulfonyl)piperazine dihydrochloride chemical structure, C13H16Cl3N3O2S, CAS 355115-40-1
1-(8-Chloro-5-isoquinolinesulfonyl)piperazine dihydrochloride
CAS 355115-40-1C13H16Cl3N3O2S
(S)-5-(3-Isobutyl-piperazine-1-sulfonyl)-isoquinoline dihydrochloride chemical structure, C17H25Cl2N3O2S, CAS 936233-01-1
(S)-5-(3-Isobutyl-piperazine-1-sulfonyl)-isoquinoline dihydrochloride
CAS 936233-01-1C17H25Cl2N3O2S
(S)-5-(3-Isobutyl-piperazine-1-sulfonyl)-isoquinoline chemical structure, C17H23N3O2S
(S)-5-(3-Isobutyl-piperazine-1-sulfonyl)-isoquinoline
C17H23N3O2S
5-[(3S)-3-Propan-2-ylpiperazin-1-yl]sulfonylisoquinoline, dihydrochloride chemical structure, C16H23Cl2N3O2S
5-[(3S)-3-Propan-2-ylpiperazin-1-yl]sulfonylisoquinoline, dihydrochloride
C16H23Cl2N3O2S
5-[3-(Propan-2-yl)piperazine-1-sulfonyl]isoquinoline--hydrogen chloride (1/2) chemical structure, C16H23Cl2N3O2S, CAS 936233-02-2
5-[3-(Propan-2-yl)piperazine-1-sulfonyl]isoquinoline--hydrogen chloride (1/2)
CAS 936233-02-2C16H23Cl2N3O2S
tert-Butyl (3S)-4-isoquinolin-5-ylsulfonyl-3-methylpiperazine-1-carboxylate, dihydrochloride chemical structure, C19H27Cl2N3O4S, CAS 936233-08-8
tert-Butyl (3S)-4-isoquinolin-5-ylsulfonyl-3-methylpiperazine-1-carboxylate, dihydrochloride
CAS 936233-08-8C19H27Cl2N3O4S
tert-Butyl 4-(isoquinolin-5-ylsulfonyl)-3-methylpiperazine-1-carboxylate chemical structure, C19H25N3O4S, CAS 1796933-25-9
tert-Butyl 4-(isoquinolin-5-ylsulfonyl)-3-methylpiperazine-1-carboxylate
CAS 1796933-25-9C19H25N3O4S
tert-Butyl 4-(isoquinolin-5-ylsulfonyl)piperazine-1-carboxylate chemical structure, C18H23N3O4S, CAS 1423128-25-9
tert-Butyl 4-(isoquinolin-5-ylsulfonyl)piperazine-1-carboxylate
CAS 1423128-25-9C18H23N3O4S