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Murcko scaffold

2,5-Piperazinedione, 1,4-diphenyl- scaffold

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
16
With full pages
3
Scaffold SMILES

O=C1CN(c2ccccc2)C(=O)CN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,5-Piperazinedione, 1,4-diphenyl- page
Murcko scaffold O=C1CN(c2ccccc2)C(=O)CN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

1,4-Bis(4-methylphenyl)piperazine-2,5-dione chemical structure, C18H18N2O2, CAS 21303-69-5
1,4-Bis(4-methylphenyl)piperazine-2,5-dione
CAS 21303-69-5C18H18N2O2
1,4-Bis(4-methoxyphenyl)piperazine-2,5-dione chemical structure, C18H18N2O4, CAS 21535-05-7
1,4-Bis(4-methoxyphenyl)piperazine-2,5-dione
CAS 21535-05-7C18H18N2O4
1,4-Bis(2,6-dimethylphenyl)piperazine-2,5-dione chemical structure, C20H22N2O2, CAS 70336-49-1
1,4-Bis(2,6-dimethylphenyl)piperazine-2,5-dione
CAS 70336-49-1C20H22N2O2
1,4-Bis[2-(trifluoromethyl)phenyl]piperazine-2,5-dione chemical structure, C18H12F6N2O2, CAS 374550-53-5
1,4-Bis[2-(trifluoromethyl)phenyl]piperazine-2,5-dione
CAS 374550-53-5C18H12F6N2O2
1,4-Bis(4-ethoxyphenyl)piperazine-2,5-dione chemical structure, C20H22N2O4, CAS 21303-71-9
1,4-Bis(4-ethoxyphenyl)piperazine-2,5-dione
CAS 21303-71-9C20H22N2O4
1,4-Bis(3-chloro-2-methylphenyl)piperazine-2,5-dione chemical structure, C18H16Cl2N2O2, CAS 396099-44-8
1,4-Bis(3-chloro-2-methylphenyl)piperazine-2,5-dione
CAS 396099-44-8C18H16Cl2N2O2
2,5-Piperazinedione, 1,4-diphenyl- chemical structure, C16H14N2O2, CAS 20635-51-2
2,5-Piperazinedione, 1,4-diphenyl-
CAS 20635-51-2C16H14N2O2
1,4-Bis(4-isopropyl-3-methylphenyl)tetrahydro-2,5-pyrazinedione chemical structure, C24H30N2O2, CAS 866152-25-2
1,4-Bis(4-isopropyl-3-methylphenyl)tetrahydro-2,5-pyrazinedione
CAS 866152-25-2C24H30N2O2
1,4-Bis(2,6-diethylphenyl)-2,5-piperazinedione chemical structure, C24H30N2O2, CAS 145143-47-1
1,4-Bis(2,6-diethylphenyl)-2,5-piperazinedione
CAS 145143-47-1C24H30N2O2
Benzoic acid, 2,2'-(2,5-dioxo-1,4-piperazinediyl)bis-, dimethyl ester chemical structure, C20H18N2O6, CAS 61193-63-3
Benzoic acid, 2,2'-(2,5-dioxo-1,4-piperazinediyl)bis-, dimethyl ester
CAS 61193-63-3C20H18N2O6
Benzoic acid, 2,2'-(2,5-dioxo-1,4-piperazinediyl)bis- chemical structure, C18H14N2O6, CAS 61193-62-2
Benzoic acid, 2,2'-(2,5-dioxo-1,4-piperazinediyl)bis-
CAS 61193-62-2C18H14N2O6
3,6-Dimethyl-1,4-diphenylpiperazine-2,5-dione chemical structure, C18H18N2O2, CAS 77868-73-6
3,6-Dimethyl-1,4-diphenylpiperazine-2,5-dione
CAS 77868-73-6C18H18N2O2
2,2'-(2,5-Dioxopiperazine-1,4-diyl)dibenzonitrile chemical structure, C18H12N4O2, CAS 116473-73-5
2,2'-(2,5-Dioxopiperazine-1,4-diyl)dibenzonitrile
CAS 116473-73-5C18H12N4O2
1,4-Bis(3,4-dichlorophenyl)-3,6-dimethylpiperazine-2,5-dione chemical structure, C18H14Cl4N2O2, CAS 63349-35-9
1,4-Bis(3,4-dichlorophenyl)-3,6-dimethylpiperazine-2,5-dione
CAS 63349-35-9C18H14Cl4N2O2
1,4-Bis(4-nitrophenyl)piperazine-2,5-dione chemical structure, C16H12N4O6, CAS 859953-42-7
1,4-Bis(4-nitrophenyl)piperazine-2,5-dione
CAS 859953-42-7C16H12N4O6
4,4'-(2,5-Dioxopiperazine-1,4-diyl)dibenzonitrile chemical structure, C18H12N4O2, CAS 2733025-09-5
4,4'-(2,5-Dioxopiperazine-1,4-diyl)dibenzonitrile
CAS 2733025-09-5C18H12N4O2